STable Coronary Artery Diseases RegisTry

Chronic Ischemic Heart Disease Clinical Trial

— START  

Official title:

STable Coronary Artery Diseases RegisTry

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03796741
• Other study ID #: K14
• Status: Completed
• Start date: March 17, 2016
• Est. completion date: April 24, 2018

Study information

• Verified date: December 2018
• Source: Heart Care Foundation
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Observational, prospective multicentric, national study, evaluating the diagnostic and therapeutic pathways of patient with cronic coronary artery disease followed in Italian cardiology centers.

Description:

Coronary heart disease is still highly prevalent in the world, and chronic stable angina is one of the most common clinical presentations of this disease. The objectives of chronic stable angina treatment include the reduction of symptoms, the inhibition or slowing of the progression of the disease, the prevention of associated cardiovascular events such as myocardial infarction, and the possible improvement of survival.The results of COURAGE Study and of meta-analysis of more recent studies demonstrate that patients in optimized medical therapy (OMT) (aspirin, beta-blocker and statin in association with an ACE-inhibitor and strict control of risk factors). ) the percutaneous coronary revascularization procedure (PCI) did not lead to an improvement in the cardiovascular prognosis. These data led the groups in charge of drafting the guidelines to recommend OMT as an initial treatment of stable angina, reserving the revascularization procedure for those patients with symptoms not adequately controlled by medical therapy.

It is therefore considered appropriate to plan a registry in patients with stable coronary artery disease that has the ability to describe in the heterogeneity of Italian cardiological centers the current characteristics of these patients, their treatment modalities, adherence to the current guidelines both as regards invasive therapy that the optimized medical, the use and the total cost of the resources needed to manage this pathology, the clinical course one year after entering the register.

Consecutive patients discharged (after an ordinary or day hospital admission) or managed as outpatient at Cardiology department participating in the project with a diagnosis of stable coronary artery disease will be included in the register. Enrollment will last 3 months in each center, starting with the first enrolled patient, or up to 50 patients enrolled.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 5070
• Est. completion date: April 24, 2018
• Est. primary completion date: February 28, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients aged >/= 18

• Patients discharged from hospital or ambulatory visit with a diagnoses of stable heart disease;

• Written informed consent

Exclusion Criteria:

• Acute coronary syndrome within 30 days from enrollment

• CCS Angina Class IV

• Angina probably not for coronary artery disease

Related Conditions & MeSH terms

• Chronic Ischemic Heart Disease
• Coronary Artery Disease
• Coronary Disease
• Heart Diseases
• Myocardial Ischemia

Intervention

Other:
• Data collection on Stable Ischemic heart disease
No intervention only description of management and treatment

Locations

Country	Name	City	State
Italy	Ospedale San Giovanni Di Dio - Uo Cardiologia E Utic	Agrigento	AG
Italy	Ospedale Ss. Vito E Spirito - U.O.S. Di Cardiologia	Alcamo	TP
Italy	Clinica Citta' Di Alessandria - Uo Cardiologia	Alessandria
Italy	Istituto Scientifico Inrca - Uo Cardiologia/Utic/Telecardiologia	Ancona	AN
Italy	Osp. Andria Canosa - Po Andria - Cardiologia - Utic	Andria	BT
Italy	Ospedali Riuniti Anzio-Nettuno - U.O. Di Cardiologia - Utic	Anzio	RM
Italy	Casa Di Cura Citta' Di Aprilia - U.O. Cardiologia	Aprilia	LT
Italy	Nuovo Ospedale Dei Castelli - U.O.C. Di Cardiologia E Utic	Ariccia	RM
Italy	Ospedale Civile - U.O.C. Cardiologia	Arzignano	VI
Italy	Ospedale Gen.Le Prov.Le C.G. Mazzoni - Sc Cardiologia	Ascoli Piceno	AP
Italy	Ospedale E. Muscatello - U.O. Di Cardiologia - Utic	Augusta	SR
Italy	Aorn San Giuseppe Moscati - U.O. Cardiologia/Utic 'D. Rotiroti'	Avellino	AV
Italy	Presidio Ospedaliero Moscati - U.O.C. Cardiologia	Aversa	CE
Italy	Ospedale G. Di Maria - Cardiologia Utic	Avola	SR
Italy	Ospedale Policlinico - U.O. Di Cardiologia Ospedaliera	Bari	BA
Italy	Ospedale San Paolo - Cardiologia-Utic	Bari	BA
Italy	Ospedale Monsignor Angelo R. Di Miccoli - Unita' Operativa Di Cardiologia	Barletta	BT
Italy	Presidio Osped. S. Maria Della Speranza - U.O. Di Cardiologia	Battipaglia	SA
Italy	Ospedale Civile - Sc Cardiologia	Belluno	BL
Italy	Azienda Ospedaliera G. Rummo - Cardiologia Interventistica E Utic	Benevento	BN
Italy	Asst Papa Giovanni Xxiii - Cardiologia 1	Bergamo	BG
Italy	Ospedale Civile Di Boscotrecase - Utic Cardiologia	Boscotrecase
Italy	Ospedale Perrino - U.O.C. Di Cardiologia	Brindisi	BR
Italy	Azienda Ospedaliera G. Brotzu - Struttura Complessa Di Cardiologia	Cagliari	CA
Italy	Presidio Ospedaliero Ss Trinita' - Sc Di Cardiologia	Cagliari	CA
Italy	Ospedale A. Cardarelli - U.O. Cardiologia E Utic	Campobasso	CB
Italy	Ospedale Di Camposampiero - U.O.A. Cardiologia	Camposampiero	PD
Italy	Ospedale Carate Brianza - Cardiologia - Carate Brianza/Giussano	Carate Brianza	MB
Italy	Capt Di Cariati - Ambulatorio Di Cardiologia	Cariati	CS
Italy	Ospedale Civile Oglio Po - U.O. Di Cardiologia-Utic	Casalmaggiore	CR
Italy	Az. Ospedaliera S. Anna E S. Sebastiano - Cardiologia E Riabilit. Cardiologica	Caserta	CE
Italy	Az. Ospedaliera S. Anna E S. Sebastiano - U.O. Cardiologia-Utic	Caserta	CE
Italy	Ics Maugeri Spa Societa' Benefit - Uo Cardiologia	Cassano Delle Murge	BA
Italy	Pineta Grande Hospital - U.O. Cardiologia	Castel Volturno	CE
Italy	P.O. Garibaldi-Nesima - U.O.C. Di Cardiologia	Catania	CT
Italy	Ospedale Ss. Annunziata - U.O. Di Cardiologia	Cento	FE
Italy	Ospedale Civile Giuseppe Tatarella - U.O. Di Cardiologia - Utic	Cerignola	FG
Italy	Ospedale M.Bufalini - U.O. Di Cardiologia-Utic	Cesena	FC
Italy	Ospedale Civile - U.O.C. Cardiologia	Chioggia	VE
Italy	Por Cirie'- Lanzo Presidio Cirie' - S.C. Cardiologia Cirie'- Ivrea	Ciriè	TO
Italy	Presidio Ospedaliero Citta' Di Castello - U.O. Di Cardiologia	Città Di Castello	PG
Italy	Presidio Osp. Di Civitanova Marche - Sc Cardiologia	Civitanova Marche	MC
Italy	Ospedale Civile San Paolo - U.O. Cardiologia - Utic	Civitavecchia	RM
Italy	Ospedale Santa Maria Dei Battuti - U.O. Di Cardiologia	Conegliano	TV
Italy	Ospedale San Giuseppe Da Copertino - U.O. Di Cardiologia-Utic	Copertino	LE
Italy	Ospedale Umberto I - Uosd Di Cardiologia	Corato	BA
Italy	Ospedale Civile San Sebastiano - Sos Cardiologia Area Nord	Correggio	RE
Italy	Ospedale Valdichiana Santa Margherita - Uos Cardiologia E Hdu	Cortona	AR
Italy	Ospedale Annunziata - Uoc Cardiologia	Cosenza	CS
Italy	Ospedale Di Cremona - Uo Di Cardiologia	Cremona	CR
Italy	Ospedale Civile Profili - U.O. Cardiologia	Fabriano	AN
Italy	Ospedale Per Gli Infermi - U.O. Cardiologia - Utic	Faenza	RA
Italy	Ospedale Santa Maria Del Prato - U.O. Di Cardiologia	Feltre	BL
Italy	Ospedale Civile Augusto Murri - U.O. Cardiologia	Fermo	FM
Italy	Arcispedale Sant'Anna - U.O. Cardiologia - Utic	Ferrara	FE
Italy	Ospedali Riuniti - S.C. Di Cardiologia Univ.-Utic	Foggia	FG
Italy	Ospedale Del Dono Svizzero - U.O.C. Di Cardiologia - Utic	Formia	LT
Italy	Ospedale Civile Dario Camberlingo - U.O. Di Cardiologia - Utic	Francavilla Fontana	BR
Italy	Ospedale San Giovanni Di Dio - Uo Cardiologia - Utic	Frattamaggiore
Italy	Ospedale Santa Caterina Novella - U.O. Di Cardiologia	Galatina	LE
Italy	Ospedale S. Antonio Abate - U.O. Di Cardiologia	Gallarate	VA
Italy	Ospedale Civile 'La Memoria' - U.O. Di Cardiologia	Gavardo	BS
Italy	Po Vittorio Emanuele Di Gela - U.O.C Cardiologia - Utic	Gela	CL
Italy	Ospedale Padre Antero Micone - Sc Cardiologia - Utic	Genova	GE
Italy	Ospedale Generale Di Zona - U.O. Cardiologia - Utic	Giugliano In Campania
Italy	Ospedale San Giovanni Di Dio - S.O.C. Cardiologia	Gorizia	GO
Italy	Ospedale Moriggia Pelascini - Unita' Operativa Di Cardiologia	Gravedona	CO
Italy	Ospedale Della Misericordia - U.O. Di Cardiologia	Grosseto	GR
Italy	Ospedale Civile - Sc Cardiologia Area Nord	Guastalla	RE
Italy	Ospedale Civile - U.O. Cardiologia-Utic	Imperia	IM
Italy	Ospedale F. Veneziale - Ssd Cardiologia Emodinamica	Isernia	IS
Italy	Ospedale Civile - S.C. Cardiologia Cirie' Ivrea	Ivrea	TO
Italy	Ospedale Di Jesi Carlo Urbani - U.O. Di Cardiologia	Jesi	AN
Italy	Ospedale Giovanni Paolo Ii - U.O. Cardiologia E Utic	Lamezia Terme	CZ
Italy	Polo Ospedaliero Integrato (C/O Icot) - Uoc Cardiologia Ed Emodinamica Univ.	Latina	LT
Italy	Casa Di Cura Petrucciani - U.O. Cardiologia - Card. Riabilitativa	Lecce	LE
Italy	Ospedale Vito Fazzi - U.O. Card. Interventistica - Emodinamica	Lecce	LE
Italy	Ospedale Vito Fazzi - U.O. Di Cardiologia	Lecce	LE
Italy	Ospedale Civile - Uo Cardiologia	Legnano	MI
Italy	Nuovo Ospedale Versilia - Sc Cardiologia	Lido Di Camaiore	LU
Italy	Ospedale Civile - S.O.C. Cardiologia-Utic	Locri	RC
Italy	Ospedale Civile - U.O. Di Cardiologia	Lugo	RA
Italy	Ics Maugeri Spa Societa' Benefit - U.O. Di Cardiologia Riabilitativa	Lumezzane	BS
Italy	Ospedale Civile Fornaroli - U.O. Cardiologia	Magenta	MI
Italy	Ospedale Civile M. Giannuzzi - Cardiologia E Utic	Manduria	TA
Italy	Presidio Ospedaliero Paolo Borsellino - U.O.C Cardiologia- Utic	Marsala	TP
Italy	Ftgm - Stabilimento Di Massa - Uoc Cardiologia Diagn. E Interventistica	Massa	MS
Italy	Ospedale Apuane - U.O. Cardiologia-Utic	Massa	MS
Italy	Ospedale S. Giovanni Di Dio - U.O. Cardiologia E Utic	Melfi	PZ
Italy	Ospedale Tiberio Evoli Riabilitazione - Cardio-Respiratoria	Melito di Porto Salvo	RC
Italy	Istituto Clinico Citta' Studi - U.O. Cardiologia	Milano	MI
Italy	Ospedale San Carlo Borromeo - Cardiologia-Ucc	Milano	MI
Italy	Ospedale San Raffaele - Utic E Subintensiva	Milano	MI
Italy	P.O. Don Tonino Bello - Uosd Cardiologia	Molfetta	BA
Italy	Ospedale Civile San Polo - S.O.C. Cardiologia	Monfalcone	GO
Italy	Policlinico Di Monza - Uo Cardiol. Clinica E Scompenso Cardiaco	Monza	MB
Italy	Ospedale Civile Minervini - Medicina Interna	Mormanno	CS
Italy	Aorn Cardarelli - U.O. Cardiologia Con Utic	Napoli
Italy	Aorn Osp. Dei Colli- Po Vincenzo Monaldi - U.O.C. Cardiologia	Napoli
Italy	Aorn Osp. Dei Colli- Po Vincenzo Monaldi - U.O.C. Cardiologia E Utic 'Vanvitelli'	Napoli
Italy	Clinica Mediterranea - U.O. Di Cardiologia	Napoli
Italy	Ospedale Del Mare - U.O. Cardiologia Con Utic	Napoli
Italy	Ospedale San Gennaro - U.O. Cardiologia E Riabilitazione Card.	Napoli
Italy	Aou Maggiore Della Carita' - Cardiologia Ii	Novara
Italy	Aou Maggiore Della Carita' Scdu Clinica Cardiologica-Cardiologia I	Novara
Italy	Clinica San Gaudenzio - Uoa Cardiologia	Novara
Italy	Ospedale San Francesco - Cardiologia - Utic	Nuoro	NU
Italy	Ospedale S. Maria Della Stella - Sc Di Cardiologia	Orvieto	TR
Italy	Iob - Policlinico San Marco - U.O. Cardiologia	Osio Sotto	BG
Italy	Aor Villa Sofia-Cervello P.O. Cervello - U.O. Cardiologia - Cervello	Palermo	PA
Italy	Casa Di Cura Candela - Uof Cardiologia	Palermo	PA
Italy	Fondazione Irccs Policlinico San Matteo - Cardiologia	Pavia	PV
Italy	Ics Maugeri Spa Societa' Benefit - U.O. Di Riabilitazione Cardiologica	Pavia	PV
Italy	Istituto Di Cura Citta' Di Pavia - U.O. Cardiologia Ii	Pavia	PV
Italy	Ospedale Civile Dello Spirito Santo - Utic E Cardiologia Interventistica	Pescara	PE
Italy	Ospedale Civile Ave Gratia Plena - U.O. Di Cardiologia E Utic	Piedimonte Matese	CE
Italy	Ospedale Villamarina - Cardiologia E Utic	Piombino	LI
Italy	Ospedale Dell'Alta Val D'Elsa - Uosd Cardiologia-Utic	Poggibonsi	SI
Italy	Ospedale Santa Maria Degli Ungheresi - U.O. Di Cardiologia	Polistena	RC
Italy	Policlinico Citta' Di Pomezia S. Anna - U.O. Cardiologia-Utic	Pomezia	RM
Italy	Ospedale Di Pordenone - S.O.C. Cardiologia	Pordenone	PN
Italy	Azienda Ospedaliera San Carlo - S.S.D. Cardiologia Riabilitativa	Potenza	PZ
Italy	Giovanni Paolo Ii - U.O.C. Cardiologia-Utic	Ragusa	RG
Italy	Ospedale Civile Santa Maria Delle Croci - U.O. Di Cardiologia	Ravenna	RA
Italy	Ao Bianchi Melacrino Morelli- Po Riuniti - Divisione Di Cardiologia	Reggio Calabria	RC
Italy	Arcispedale Santa Maria Nuova - S.C. Cardiologia	Reggio Emilia	RE
Italy	P.O. San Camillo de Lellis - U.O.C. Cardiologia	Rieti	RI
Italy	Ospedale Di Roccadaspide - Cardiologia-Utic	Roccadaspide	SA
Italy	Aurelia Hospital - U.O.C Cardiologia	Roma	RM
Italy	Campus Biomedico - Cardiologia	Roma	RM
Italy	European Hospital - Uo. Cardiologia Interventistica	Roma	RM
Italy	Ospedale Madre Giuseppina Vannini - U.O.C. Cardiologia	Roma	RM
Italy	Ospedale San Camillo - Cardiologia 2 (Ex Cardio 3)	Roma	RM
Italy	Ospedale San Camillo - Uoc Cardiologia 1	Roma	RM
Italy	Ospedale San Pietro Fatebenefratelli - U.O Complessa Di Cardiologia	Roma	RM
Italy	Ospedale Sandro Pertini - Uoc Cardiologia	Roma	RM
Italy	Ospedale Sant'Andrea Di Roma - U.O.C. Cardiologia	Roma	RM
Italy	Ospedale Santo Spirito - U.O.C. Di Cardiologia	Roma	RM
Italy	P.O. San Filippo Neri - Asl Roma 1 - Uoc Cardiologia E Utic	Roma	RM
Italy	Policlinico Umberto Primo - Cardiologia B - Cardiologia E Angiologia	Roma	RM
Italy	Policlinico Umberto Primo - Malattie Cardiovascolari A	Roma	RM
Italy	Ospedale Santa Maria Della Misericordia - U.O.C. Cardiologia	Rovigo	RO
Italy	Istituto Clinico Humanitas - Uo Emodinamica Cardiologia Invasiva Ucc	Rozzano	Mi
Italy	Aou S. Giovanni Di Dio-Ruggi D'Aragona - Uoc Cardiologia Preventiva	Salerno	SA
Italy	Ospedale Madonna Del Soccorso - Uoc Cardiologia Indirizzo Riabilitativo	San Benedetto Del Tronto	AP
Italy	Ospedale G. Fracastoro - U.O.C. Di Cardiologia	San Bonifacio	VR
Italy	Irccs Policlinico San Donato - U.O. Cardiologia Con Utic	San Donato Milanese	MI
Italy	Ospedale Casa Sollievo Della Sofferenza - Cardiologia - Utic - Riabil Cardiologica	San Giovanni Rotondo	FG
Italy	Casa Di Salute Santa Lucia - U.O. Cardiologia	San Giuseppe Vesuviano
Italy	Ospedale Di S. Vito Al Tagliamento - S.O.C. Cardiologia	San Vito Al Tagliamento	PN
Italy	Presidio Ospedaliero - U.O. Cardiologia	Sanremo	IM
Italy	P.O. Sant'Agata Di Militello - Uoc Cardiologia	Sant'Agata Di Militello	ME
Italy	Ospedale San Giuseppe E Melorio - U.O.C. Cardiologia Utic	Santa Maria Capua Vetere	CE
Italy	Presidio Ospedaliero Di Saronno - U.O.C. Di Cardiologia	Saronno	VA
Italy	Ospedale San Bartolomeo - U.O. Cardiologia Clinica-Riabilitativa	Sarzana	SP
Italy	Ospedale Di Sassuolo - Cardiologia	Sassuolo	MO
Italy	Ospedale Ignazio Veris Delli Ponti - Uoc Cardiologia-Utic	Scorrano	LE
Italy	Ospedale Principe Di Piemonte - Uoc Cardiologia Utic	Senigallia	AN
Italy	Presidio Ospedaliero San Rocco - U.O.C. Cardiologia - Utic	Sessa Aurunca	CE
Italy	Irccs Policlinico Multimedica - Uo Di Cardiologia	Sesto San Giovanni	MI
Italy	Aou Senese Ospedale S. Maria Alle Scotte - U.O.C. Cardiologia Ospedaliera	Siena	SI
Italy	Ospedale Umberto I - Uoc Cardiologia E Utic	Siracusa	SR
Italy	Ospedale Di Circolo A. Bellini - Medicina Generale E Card. Riabilitativa	Somma Lombardo	VA
Italy	Casa Di Cura Villa Verde - Cardiologia	Taranto	TA
Italy	Ospedale Civile G. Mazzini -Cardiologia Utic Ed Emodinamica	Teramo	TE
Italy	Centro Polifunzionale Boldrini - Cardiologia Riabilitativa-Cardioaction	Thiene	VI
Italy	Ospedale San Giovanni Evangelista - U.O.C. Di Cardiologia - Utic	Tivoli	RM
Italy	Maria Pia Hospital - U.O. Cardiologia	Torino	TO
Italy	Ospedale Di Circolo Galmarini - Cardiologia	Tradate	VA
Italy	Ospedale Santa Chiara - Divisione Di Cardiologia	Trento	TN
Italy	Azienda Osp. Cardinale G. Panico - U.O. Cardiologia - Utic	Tricase	LE
Italy	Ospedali Riuniti - Osp. Maggiore - A.F. Cardiologia E Riabil. Cardiologica	Trieste	TS
Italy	I.R.C.C.S. Oasi Maria Ss. - U.O. Cardiologia	Troina	EN
Italy	Pou Santa Maria Della Misericordia - S.O.C. Cardiologia	Udine	UD
Italy	Ospedale San Luca - U.O. Utic - Cardiologia	Vallo Della Lucania	SA
Italy	Ospedale Di Circolo E Fondazione Macchi - Cardiologia I	Varese	VA
Italy	Ospedale Civile Di Venezia - U.O. Di Cardiologia	Venezia	VE
Italy	Ospedale Sant'Andrea - Sc Cardiologia	Vercelli	VC
Italy	Ics Maugeri Spa Societa' Benefit - Uo Cardiologia Riabilitativa	Veruno
Italy	Ospedale Civile - Cardiologia	Vigevano	PV
Italy	Ospedale Belcolle - U.O.C. Cardiologia Utic Emodinamica	Viterbo	VT
Italy	Ospedale Riccardo Guzzardi - U.O.C. Di Cardiologia-Utic	Vittoria	RG
Italy	Ospedale Di Vizzolo Predabissi - Uo Cardiologia E Ucc	Vizzolo Predabissi	MI

Sponsors (1)

Lead Sponsor	Collaborator
Heart Care Foundation

Country where clinical trial is conducted

Italy, 

References & Publications (9)

Colivicchi F, Massimo Gulizia M, Arca M, Luigi Temporelli P, Gonzini L, Venturelli V, Morici N, Indolfi C, Gabrielli D, De Luca L. Lipid Lowering Treatment and Eligibility for PCSK9 Inhibition in Post-Myocardial Infarction Patients in Italy: Insights from Two Contemporary Nationwide Registries. Cardiovasc Ther. 2020 Jan 3;2020:3856242. doi: 10.1155/2020/3856242. eCollection 2020. — View Citation

De Luca L, Arca M, Temporelli PL, Colivicchi F, Gonzini L, Lucci D, Bosco B, Callerame M, Lettica GV, Di Lenarda A, Gulizia MM; START Investigators. Prevalence and pharmacologic management of familial hypercholesterolemia in an unselected contemporary cohort of patients with stable coronary artery disease. Clin Cardiol. 2018 Aug;41(8):1075-1083. doi: 10.1002/clc.23031. Epub 2018 Aug 20. — View Citation

De Luca L, Arca M, Temporelli PL, Meessen J, Riccio C, Bonomo P, Colavita AR, Gabrielli D, Gulizia MM, Colivicchi F; START Investigators. Current lipid lowering treatment and attainment of LDL targets recommended by ESC/EAS guidelines in very high-risk patients with established atherosclerotic cardiovascular disease: Insights from the START registry. Int J Cardiol. 2020 Oct 1;316:229-235. doi: 10.1016/j.ijcard.2020.05.055. Epub 2020 May 26. — View Citation

De Luca L, Formigli D, Meessen J, Uguccioni M, Cosentino N, Paolillo C, Di Lenarda A, Colivicchi F, Gabrielli D, Gulizia MM, Scherillo M; START Investigators. COMPASS criteria applied to a contemporary cohort of unselected patients with stable coronary artery diseases: insights from the START registry. Eur Heart J Qual Care Clin Outcomes. 2020 Jun 19. pii: qcaa054. doi: 10.1093/ehjqcco/qcaa054. [Epub ahead of print] — View Citation

De Luca L, Temporelli PL, Amico AF, Gonzini L, Uguccioni M, Varani E, Brunetti ND, Colivicchi F, Gabrielli D, Gulizia MM. Impact of history of depression on 1-year outcomes in patients with chronic coronary syndromes: An analysis of a contemporary, prospective, nationwide registry. Int J Cardiol. 2021 Jan 8. pii: S0167-5273(20)34334-5. doi: 10.1016/j.ijcard.2020.12.086. [Epub ahead of print] — View Citation

De Luca L, Temporelli PL, Lucci D, Colivicchi F, Calabrò P, Riccio C, Amico A, Mascia F, Proia E, Di Lenarda A, Gulizia MM; START Investigators. Characteristics, treatment and quality of life of stable coronary artery disease patients with or without angina: Insights from the START study. PLoS One. 2018 Jul 12;13(7):e0199770. doi: 10.1371/journal.pone.0199770. eCollection 2018. — View Citation

De Luca L, Temporelli PL, Lucci D, Gonzini L, Riccio C, Colivicchi F, Geraci G, Formigli D, Maras P, Falcone C, Di Lenarda A, Gulizia MM; START Investigators. Current management and treatment of patients with stable coronary artery diseases presenting to — View Citation

De Luca L, Temporelli PL, Riccio C, Gonzini L, Marinacci L, Tartaglione SN, Costa P, Scherillo M, Senni M, Colivicchi F, Gulizia MM; START Investigators. Clinical outcomes, pharmacological treatment, and quality of life of patients with stable coronary ar — View Citation

De Luca L, Uguccioni M, Meessen J, Temporelli PL, Tomai F, De Rosa FM, Passamonti E, Formigli D, Riccio C, Gabrielli D, Colivicchi F, Gulizia MM, Perna GP. External applicability of the ISCHEMIA trial: an analysis of a prospective, nationwide registry of patients with stable coronary artery disease. EuroIntervention. 2020 Dec 18;16(12):e966-e973. doi: 10.4244/EIJ-D-20-00610. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Number of patients in medical therapy and that underwent revascularization	Number of patients in medical therapy and that underwent revascularization	Enrollment
Secondary	Number of patient in optimal medical therapy	Patient treated according to International Guidelines	12 months Follow-up
Secondary	Mortality rate	Rate of patients died	12 months Follow-up
Secondary	All cause hospitalization rate	Rate of patients hospitalized	12 months Follow-up
Secondary	Angina recurrence rate	Rate of patients with angina symtoms	12 months Follow-up