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Chronic Ischemic Heart Disease clinical trials

View clinical trials related to Chronic Ischemic Heart Disease.

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NCT ID: NCT03809689 Recruiting - Clinical trials for Myocardial Infarction, Acute

Study of Cardiac Lesions Angiogenesis by 68Ga-NODAGA-RGD Cardiac PET

Start date: November 1, 2018
Phase: N/A
Study type: Interventional

The study is about exploring physiological angiogenesis linked to tissue repair in patients with acute heart infarction or chronic heart ischemia by means of 68Ga-NODAGA-RGD PET/CT imaging.

NCT ID: NCT03796741 Completed - Clinical trials for Chronic Ischemic Heart Disease

STable Coronary Artery Diseases RegisTry

Start date: March 17, 2016
Study type: Observational

Observational, prospective multicentric, national study, evaluating the diagnostic and therapeutic pathways of patient with cronic coronary artery disease followed in Italian cardiology centers.

NCT ID: NCT03505346 Recruiting - Clinical trials for Chronic Ischemic Heart Disease

68 Ga-NODAGA-E[c(RGDγK)]2: Positron Emission Tomography Tracer for Imaging of Angiogenesis in Ischemic Heart Disease

Start date: January 1, 2019
Phase: Phase 2
Study type: Interventional

The aim is to examine the expression of αvβ3 integrin using a novel selective radiotracer in patients with chronich ischemic heart disease and investigate if it is a suitable tool for predicting myocardial recovery and thus prognosis after intervention.

NCT ID: NCT03043742 Recruiting - Clinical trials for Chronic Ischemic Heart Disease

Stem Cell Heart Injections During Laser Revascularization Surgery for Treatment of Chronic Ischemic Heart Disease

Start date: July 12, 2016
Phase: Phase 1
Study type: Interventional

Assess the safety and effectiveness of stem cell application with regard to improvement in regional myocardial function in patients receiving Trans-Myocardial Laser Revascularization (TMR) and stem cells.

NCT ID: NCT02439541 Recruiting - Heart Failure Clinical Trials

Human Umbilical-Cord-Derived Mesenchymal Stem Cell Therapy in Ischemic Cardiomyopathy

Start date: May 2015
Phase: Phase 1/Phase 2
Study type: Interventional

Phase I-II Clinical Trial-Safety and efficacy of umbilical cord derived mesenchymal stem cells (UC-MSCs) in patients with chronic heart ischemia cohort and perspective study.

NCT ID: NCT01727063 Recruiting - Clinical trials for Coronary Artery Disease

Cell Therapy in Severe Chronic Ischemic Heart Disease

Start date: January 2006
Phase: Phase 2/Phase 3
Study type: Interventional

Patients with advanced coronary artery disease usually undergo incomplete myocardial revascularization due to the extension and diffuseness of the disease, with very poor distal arterial beds unsuitable for direct revascularization. This study was designed to test the hypothesis that direct, intramyocardial injection of autologous bone marrow cells may further improve myocardial perfusion in patients undergoing incomplete bypass surgery.

NCT ID: NCT01666132 Terminated - Clinical trials for Chronic Ischemic Heart Disease

METHOD - Bone Marrow Derived Mononuclear Cells in Chronic Ischemic Disease

Start date: January 2011
Phase: Phase 1/Phase 2
Study type: Interventional

Intramyocardial, NOGA guided injection of bone marrow derived mononuclear cells in patients with chronic ischemic heart disease and LVEF < 40%. The primary objective is to determine whether the administration of the cells improves recovery of the left ventricular function. Secondary objective is the finding of clinical or paraclinical parameters to predict potential benefits of the treatment (basing on MRI characteristics such as size, transmurality of the myocardial infarction and peri-lesional ischemia). In the first part of the study 10 patients are treated without control group. This phase serves as feasibility and safety part of the study.

NCT ID: NCT01449032 Completed - Clinical trials for Chronic Ischemic Heart Disease

MesenchYmal STROMAL CELL Therapy in Patients With Chronic Myocardial Ischemia (MyStromalCell Trial)

Start date: April 2010
Phase: Phase 2
Study type: Interventional

Coronary artery disease (CAD) is the most common cause of death and a major cause of hospital admissions for acute chest pain. In spite of improved treatments still many patients with CAD have daily attacks of severe chest pain and severely reduced life quality. The investigators have established a double-blind placebo-controlled trial in patients with CAD to test efficacy and safety of treatment with adipose derived stem cells to improve perfusion in the heart muscle and exercise capacity, and reduce the patient's symptoms.

NCT ID: NCT00824005 Completed - Clinical trials for Ischemic Cardiomyopathy

Effectiveness of Stem Cell Treatment for Adults With Ischemic Cardiomyopathy (The FOCUS Study)

Start date: March 2009
Phase: Phase 2
Study type: Interventional

Coronary artery disease (CAD) is a common disorder that can lead to heart failure. Not all people with CAD are eligible for today's standard treatments. One new treatment approach uses stem cells—specialized cells capable of developing into other types of cells—to stimulate growth of new blood vessels for the heart. This study will determine the safety and effectiveness of withdrawing stem cells from someone's bone marrow and injecting those cells into the person's heart as a way of treating people with CAD and heart failure.