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Caries clinical trials

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NCT ID: NCT05211843 Recruiting - Caries Clinical Trials

Saliva Insulin as Biomarker of Risk Factors for Metabolic Dysregulation and Caries

Start date: October 12, 2022
Phase: N/A
Study type: Interventional

Saliva insulin shows promise as a non-invasive biomarker of high carbohydrate intake and/or insulin resistance, key risk factors for metabolic dysregulation and caries. Saliva insulin monitoring could potentially inform the planning and evaluation of interventions to prevent child obesity, diabetes and caries, without relying on self-reported measures from children, parents, child care providers or teachers. School-based public health screening programs, which have staff and data collection infrastructure in place to regularly and systematically collect saliva during oral health screening, have opportunity to monitor saliva insulin. This randomized controlled trial explores if saliva insulin is responsive to the kinds of obesity and caries intervention currently in progress in schools, namely drinking water intervention. Public health programs may justify adding saliva collection to protocol already in place if saliva insulin data are found to be actionable, i.e. sensitive to risk and intervention.

NCT ID: NCT05178823 Completed - Caries Clinical Trials

Short- and Long Term Antibacterial Effects of a Single Rinse With Different Mouthwashes: a Randomized Clinical Trial

Start date: June 1, 2017
Phase: Phase 4
Study type: Interventional

Objectives: To reduce the microbial level in the aerosol created during dental procedures is essential in avoiding infections. The aim of this study was to examine the change of Streptococcus mutans (S. mutans) and the total bacterial load in human saliva in vivo after a single rinse with different mouthwashes. Material and methods: One mL unstimulated saliva was collected from volunteers with poor oral hygiene at baseline and 5 min after a one-min rinsing with Solumium Oral® (hyper-pure 0.0015% chlorine dioxide; ClO2), Listerine Total Care®, Corsodyl® (0.2% chlorhexidine-digluconate; CHX), or BioGate Si*CLEAN for bacterial investigation. In a second study volunteers rinsed with 0.003% ClO2 or CHX for one-min and saliva was collected at baseline, after 5 and 90 min. After plating the total plate and S. mutans colony numbers were determined.

NCT ID: NCT05144711 Recruiting - Caries Clinical Trials

Management of Deep Carious Lesions in Adults

Start date: October 3, 2021
Phase: N/A
Study type: Interventional

Dental caries is one of the most prevalent non-communicable disease. However, despite its prevalence there is no consensus on how much caries to remove prior to placing a restoration to achieve optimal outcomes. Evidence for selective compared to complete nonselective excavation suggests there may be benefit for selective removal in sustaining tooth vitality while histological studies reveal that the remaining dentine is actually infected and may cause loss of vitality in long term. The aim of this study is to randomly compare selective to non-elective excavation methods in carious mature permanent teeth with symptoms of reversible pulpitis

NCT ID: NCT05127343 Not yet recruiting - Caries Clinical Trials

Comparison Between Resin Based and Glass Ionomer Based Hydrophilic Fissure Sealants

Start date: February 2022
Phase: N/A
Study type: Interventional

The aim of the study is to clinically evaluate the retention and caries formation of hydrophilic fissure sealants among adolescents after one year.

NCT ID: NCT05109299 Not yet recruiting - Caries Clinical Trials

Antibacterial Effect of Miswak Toothpaste Compared to Fluoride Toothpaste

Start date: December 1, 2021
Phase: N/A
Study type: Interventional

Meswak is scientifically formulated herbal toothpaste with pure extract of the Miswak plant 'Salvadore Persica', the famous 'Toothbrush Tree' used for centuries. The astringent and anti-bacterial properties of Meswak helps reduce tooth decay , fight plaque and prevent gum diseases. Miswak Herb is a rare, potent, priceless, wonder herb that delivers incredible Dental Care benefits.

NCT ID: NCT05070416 Not yet recruiting - Caries Clinical Trials

Lithium Disilicate Crowns Study

Start date: October 1, 2021
Phase: N/A
Study type: Interventional

CAD-CAM crowns made of lithium disilicate are placed in patients by using either a dual-curing adhesive or a self-adhesive luting material in combination with total etch/universal bonding agent.

NCT ID: NCT05064566 Not yet recruiting - Diagnoses Disease Clinical Trials

Evaluation of Caries Detection Methods

Start date: October 20, 2021
Phase:
Study type: Observational

The investigators aim will be to compare the diagnostic performance of clinical visual examination (ICDAS II), intraoral/bite wing radiography (BW), near infrared light transillumination (NIR-LT), and laser fluorescence (LF), in comparison to microcomputed tomography (micro-CT) for the detection of non-cavitated occlusal enamel and dentin caries in third molar teeth. Potential participants will be consecutively recruited.

NCT ID: NCT05033015 Active, not recruiting - Caries Clinical Trials

Effect of Enzyme-containing Mouth Rinse on Dental Biofilm in Patients With Fixed Orthodontic Appliances

Start date: March 1, 2021
Phase: N/A
Study type: Interventional

Caries is a biofilm-mediated global public health problem causing health, social and economic consequences for individuals, communities and countries. Treatment with fixed orthodontic appliances is associated with impaired oral hygiene. This results in a demineralization of the enamel (white spot lesions). The prevalence is fairly high (30-50%) among adolescents and self-applied fluorides cannot completely prevent such lesions. It is therefore important to investigate novel approaches to combat these unwanted adverse effects. A systematic review has suggested that mouthwashes may be suitable technology to control biofilm accumulation in orthodontic patients. The aim of the present pilot study is to evaluate the effect of a novel mouth rinse containing a blend of natural enzymes in addition to fluoride on the presence of oral biofilm in patients undergoing treatment with fixed orthodontic appliances.

NCT ID: NCT04996641 Withdrawn - Clinical trials for Head and Neck Cancer

Endodontic-Restorative Pre-Radiation Therapy of Head and Neck Cancer Patients

EndoRest
Start date: January 3, 2022
Phase: N/A
Study type: Interventional

Pilot study involving 20 patients undergoing dental treatment prior to radiation therapy. Comparison of outcome parameters to existing data of age and gender matched patients.

NCT ID: NCT04973761 Completed - Caries Clinical Trials

Quality of Life for Children With Zirconium Anteroir Crowns Versus Strip Composite Crowns

Start date: March 1, 2018
Phase: N/A
Study type: Interventional

Early Childhood Oral Health Impact Scale (ECOHIS) will be used for detection of oral health related quality of life for children using strip composite crowns versus zirconium crowns at 6 and 12 months