Functional Outcomes of Stay Strong Stay Healthy Program

Cardiovascular Diseases Clinical Trial

Official title:

Functional Outcomes of Stay Strong, Stay Healthy Program

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02677363
• Other study ID #: 208531
• Status: Completed
• Phase: N/A
• First received: February 2, 2016
• Last updated: April 2, 2018
• Start date: February 2016
• Est. completion date: June 2017

Study information

• Verified date: April 2018
• Source: University of Missouri-Columbia
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Strength training can increase muscle mass and strength while improving bone density and reducing risk for osteoporosis and related fractures. Strength training can also lead to reduced risk for diabetes, heart disease, arthritis, depression, and obesity; and improves self-confidence, sleep and vitality. Research demonstrates that strength training is extremely effective in helping aging adults with chronic conditions prevent further onset of disease and, in many instances, actually reverse the disease process. In Stay Strong, Stay Healthy Program elderly subjects perform resistance exercise training (RET) twice every week. Past literature suggests that resistance training improved muscle activity, muscle strength, muscle mass, and bone mineral density and total body composition, and adiponectin, insulin sensitivity, fasting blood-glucose (BG), HbA1c1 (long-term marker of BG), blood pressure (BP), blood triglycerides (TGs) and low density lipoproteins (LDL) in healthy and diabetic subjects. The purpose of this study is to measure the changes in the above discussed variables after 8-weeks of resistance exercises.

Description:

Participants will perform resistance exercise for 8 weeks and measurements (anthropometric, electromyography, pulse wave velocity, strength test, dual x-ray absorptiometry, blood enzymes/hormones, and sleep, diet, memory surveys) will be performed pre- and post-exercise program.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: June 2017
• Est. primary completion date: June 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 60 Years and older

Eligibility

Inclusion Criteria:

• Age 60 or above

• Enrollment in Stay Strong Stay Healthy Program

• Strength training < 2 hours/week for past 3 months

Exclusion Criteria:

• Not enrolled in Stay Strong Stay Healthy Program

• Strength training > 2 hours/week for past 3 months

• Donated more than 463 ml of blood in past 8 weeks

• Physician discouraged to participate

Related Conditions & MeSH terms

• Aging
• Cardiovascular Diseases
• Memory Disorders
• Memory Loss
• Quality of Life

Intervention

Other:
• Resistance Exercise
Participants 60 and above aged (both females and males) will perform one hour of resistance exercise twice weekly for 8 weeks.

Locations

Country	Name	City	State
United States	University of Missouri-Columbia	Columbia	Missouri

Sponsors (1)

Lead Sponsor	Collaborator
University of Missouri-Columbia

Country where clinical trial is conducted

United States, 

References & Publications (7)

Ball S, Gammon R, Kelly PJ, Cheng AL, Chertoff K, Kaume L, Abreu EL, Brotto M. Outcomes of Stay Strong, Stay Healthy in community settings. J Aging Health. 2013 Dec;25(8):1388-97. doi: 10.1177/0898264313507318. Epub 2013 Oct 22. — View Citation

Geirsdottir OG, Arnarson A, Briem K, Ramel A, Jonsson PV, Thorsdottir I. Effect of 12-week resistance exercise program on body composition, muscle strength, physical function, and glucose metabolism in healthy, insulin-resistant, and diabetic elderly Icelanders. J Gerontol A Biol Sci Med Sci. 2012 Nov;67(11):1259-65. doi: 10.1093/gerona/gls096. Epub 2012 Apr 10. — View Citation

Kraemer WJ, Ratamess NA. Hormonal responses and adaptations to resistance exercise and training. Sports Med. 2005;35(4):339-61. Review. — View Citation

Macaluso A, De Vito G. Muscle strength, power and adaptations to resistance training in older people. Eur J Appl Physiol. 2004 Apr;91(4):450-72. Epub 2003 Nov 25. Review. — View Citation

Mayer F, Scharhag-Rosenberger F, Carlsohn A, Cassel M, Müller S, Scharhag J. The intensity and effects of strength training in the elderly. Dtsch Arztebl Int. 2011 May;108(21):359-64. doi: 10.3238/arztebl.2011.0359. Epub 2011 May 27. Review. — View Citation

Pollock ML, Franklin BA, Balady GJ, Chaitman BL, Fleg JL, Fletcher B, Limacher M, Piña IL, Stein RA, Williams M, Bazzarre T. AHA Science Advisory. Resistance exercise in individuals with and without cardiovascular disease: benefits, rationale, safety, and prescription: An advisory from the Committee on Exercise, Rehabilitation, and Prevention, Council on Clinical Cardiology, American Heart Association; Position paper endorsed by the American College of Sports Medicine. Circulation. 2000 Feb 22;101(7):828-33. Review. — View Citation

Sale DG. Neural adaptation to resistance training. Med Sci Sports Exerc. 1988 Oct;20(5 Suppl):S135-45. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Muscle electrical activity	Measurement of muscle electrical activity is made using electromyography technique at baseline and after 8 weeks of resistance exercise.	Change in muscle electrical activity in 8 weeks in response to resistance exercise program
Secondary	Exert muscle power/strength	Measurement of muscle power/strength is made using hand dynamometer at baseline and after 8 weeks of resistance exercise.	Change in muscle power/strength in 8 weeks in response to resistance exercise program
Secondary	Muscle mass loss	Changes in the muscle mass is made using dual x-ray absorptiometry technique at baseline and after 8 weeks of resistance exercise.	Change in muscle mass in 8 weeks in response to resistance exercise program
Secondary	Ability to think or remember	Changes in ability to think or remember is measured by using standard survey (Self Administered Gerocognitive Exam Form -1) at baseline and after 8 weeks of resistance exercise.	Changes in thinking and cognitive abilities in 8 weeks in response to resistance exercise program