Lipid Research Clinics Population Studies

Cardiovascular Diseases Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00005128
• Other study ID #: 907
• Status: Completed
• Phase: N/A
• First received: May 25, 2000
• Last updated: April 13, 2016
• Start date: July 1972
• Est. completion date: December 1994

Study information

• Verified date: April 2004
• Source: National Heart, Lung, and Blood Institute (NHLBI)
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Observational

Clinical Trial Summary

To conduct epidemiologic surveys of the distribution, causes, and consequences of the dyslipoproteinemias. The Population Studies include the Prevalence Study, the Family Study, and the Mortality Follow-up Study and shared the same general population base.

Description:

BACKGROUND:

The Lipid Research Clinics program was created in 1971. The objectives were to evaluate the then current techniques for diagnosis of hyperlipoproteinemia; to acquire data across all age groups on the prevalence of different types of hyperlipoproteinemia, particularly genetically determined forms; to collect high quality data on the prevalence and incidence of atherosclerosis in different patterns of hyperlipoproteinemia; and to improve methods for detection, diagnosis, and medical care of coronary heart disease. The program consisted of the Population Studies and the Coronary Primary Prevention Trial. The coronary primary prevention trial is described under Clinical Trials in the database.

As a result of the establishment of the U.S.-U.S.S.R. Joint Program in Cardiovascular Diseases in 1972, lipid research clinics were established in Moscow and Leningrad in 1974. The U.S.S.R. component of this collaborative research consisted of two Prevalence Studies and a Follow-up Study, all of which closely followed the U.S. Lipid Research Clinics Prevalence Study protocol.

DESIGN NARRATIVE:

Prevalence Study:

The Prevalence Study was initiated in 1972 to determine the prevalence of different types of dyslipoproteinemias at ten North American Lipid Research Clinics. The Prevalence Study consisted of two screens designated as Visit 1 and Visit 2, and was conducted according to a standardized protocol in well-defined target populations. Data collection began in 1972 and ended in 1976. The median time between the two screens was 96 days. The objectives of Visit 1 were: to provide estimates of the prevalence of dyslipidemia in specified populations; to investigate the distribution of cholesterol and triglyceride; and to select participants for Visit 2. A total of 60,502 eligible participants were screened at visit 1. A 15 percent random sample (N=9,107) of all Visit 1 participants who had elevated lipids (N=6,882) or were taking lipid-altering medication (N=346) were asked to return for the Lipid Research Clinics Population Studies Visit 2 screen. The three groups of 16,335 participants represented approximately 25 percent of all subject screened at Visit 1. The objectives of Visit 2 were: to identify participants with primary or secondary dyslipoproteinemia; to determine the prevalence of lipid and lipoprotein patterns and their associations with coronary heart disease, other vascular diseases, and other risk factors for coronary heart disease; and to determine the relationships between lipids and lipoprotein patterns and selected nutritional, physiologic, and sociodemographic variables such as education and occupation of head of household, smoking, blood pressure, height, weight, triceps skinfold, Quetelet index, and sex hormone usage by females. Visit 2 procedures included an interview, a physical examination, an ECG, clinical chemistries, and one-day dietary recall.

Family Study:

The Family Study provided data on the relationship of familial and genetic attributes to plasma lipids and lipoproteins. A sample of all participants in Visit 2 of the Prevalence Study was chosen to participate as probands. Basic demographic information was collected and plasma lipids and lipoproteins were measured on all first-degree relatives and probands. The Family Study was initiated in 1975 and data collection was completed in 1978.

Follow-Up Study:

The Follow-up Study, initiated in 1977, was designed to relate the baseline observation made in 1972-1976 to total and cause-specific mortality. The study assessed the risk factor status of plasma triglycerides, HDL cholesterol and exercise electrocardiography for cardiovascular disease mortality in general, and coronary heart disease in particular. Follow-up baseline measurements included lipid and other clinical chemistries, one-day dietary recalls, medication histories and physical examinations. Assessments were also made of the relationships of estrogen use in women to subsequent cardiovascular disease, coronary heart disease, and cancer mortality and of the relationships of lipids and lipoprotein levels to site-specific cancer, as well as the relationship of retinol levels to cancer mortality.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 0
• Est. completion date: December 1994
• Accepts healthy volunteers: No
• Gender: Male
• Age group: N/A to 100 Years
• Eligibility: No eligibility criteria

Study Design

N/A

Related Conditions & MeSH terms

• Atherosclerosis
• Cardiovascular Diseases
• Coronary Artery Disease
• Coronary Disease
• Heart Diseases
• Hyperlipoproteinemia
• Hyperlipoproteinemias

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
National Heart, Lung, and Blood Institute (NHLBI)

References & Publications (142)

Abernathy JR, Thorn MD, Ekelund LG, Holme I, Stinnett SS, Shestov DB, Deev AD. Correlates of systolic and diastolic blood pressure in men 40 to 59 years of age sampled from United States of America and Union of Soviet Socialist Republics Lipid Research Clinics populations. Am J Cardiol. 1988 May 1;61(13):1071-5. — View Citation

Abernathy JR, Thorn MD, Trobaugh GB, Ekelund LG, Maciolowski M, Lupovetsky B, Shelnova S, Zhukovsky G, Shestov D, Deev A. Prevalence of ischemic resting and stress electrocardiographic abnormalities and angina among 40- to 59-year-old men in selected U.S. and U.S.S.R. populations. Circulation. 1988 Feb;77(2):270-8. — View Citation

Ahmed S, Lippel K, Bachorik P, Albers J, Williams J, Cooper G. Analytical performance and comparability of the determination of triglycerides by 12 Lipid Research Clinic laboratories. Clin Chem. 1978 Feb;24(2):330-8. — View Citation

Ahmed S, Lippel K, Bachorik PS, Muesing R, Weidman S, Winn C. External quality control survey of triglyceride (triacylglycerol) analyses performed by 12 lipid research clinics. Clin Chem. 1979 Jun;25(6):880-8. — View Citation

Albers JJ, Warnick GR, Johnson N, Bachorik PS, Muesing R, Lippel K, Williams OD. Quality control of plasma high-density lipoprotein cholesterol measurement methods. Circulation. 1980 Nov;62(4 Pt 2):IV9-18. — View Citation

Albers JJ, Warnick GR, Wiebe D, King P, Steiner P, Smith L, Breckenridge C, Chow A, Kuba K, Weidman S, Arnett H, Wood P, Shlagenhaft A. Multi-laboratory comparison of three heparin-Mn2+ precipitation procedures for estimating cholesterol in high-density lipoprotein. Clin Chem. 1978 Jun;24(6):853-6. Review. — View Citation

Bachorik PS, Cooper G, Lippel K, and Ahmed S: Standardization of Cholesterol and Triglyceride Measurements by 12 Lipid Research Clinics. In Protides of the Biological Fluids (Proceedings of the 25th Colloquium), H. Peeters, (Ed). New York: Pergamon Press, pp. 307-314, 1978

Bachorik PS, Most B, Lippel K, Albers JJ, Wood PD. Plasma lipoprotein analysis: relative precision of total cholesterol and lipoprotein-cholesterol measurements in 12 lipid-research-clinics laboratories. Clin Chem. 1981 Jul;27(7):1217-22. — View Citation

Bachorik PS, Wood PD, Albers JJ, Steiner P, Dempsey M, Kuba K, Warnick R, Karlsson L. Plasma high-density lipoprotein cholesterol concentrations determined after removal of other lipoproteins by heparin/manganese precipitation or by ultracentrifugation. Clin Chem. 1976 Nov;22(11):1828-34. — View Citation

Bachorik PS, Wood PD, Williams J, Kuchmak M, Ahmed S, Lippel K, Albers J. Automated determination of total plasma cholesterol: a serum calibration technique. Clin Chim Acta. 1979 Aug 15;96(1-2):145-53. — View Citation

Bangdiwala SI, Cohn R, Hazard C, Davis CE, Prineas RJ. Comparisons of cause of death verification methods and costs in the lipid research clinics program mortality follow-up study. Control Clin Trials. 1989 Jun;10(2):167-87. — View Citation

Barrett-Connor E, Wilcosky T, Wallace RB, Heiss G. Resting and exercise electrocardiographic abnormalities associated with sex hormone use in women. The Lipid Research Clinics Program Prevalence Study. Am J Epidemiol. 1986 Jan;123(1):81-8. — View Citation

Beaglehole R, LaRosa JC, Heiss G, Davis CE, Williams OD, Tyroler HA, Rifkind BM. Serum cholesterol, diet, and the decline in coronary heart disease mortality. Prev Med. 1979 Sep;8(5):538-47. — View Citation

Beaglehole R, Trost DC, Tamir I, Kwiterovich P, Glueck CJ, Insull W, Christensen B. Plasma high-density lipoprotein cholesterol in children and young adults. The Lipid Research Clinics Program Prevalence Study. Circulation. 1980 Nov;62(4 Pt 2):IV83-92. — View Citation

Beaton GH, Milner J, Corey P, McGuire V, Cousins M, Stewart E, de Ramos M, Hewitt D, Grambsch PV, Kassim N, Little JA. Sources of variance in 24-hour dietary recall data: implications for nutrition study design and interpretation. Am J Clin Nutr. 1979 Dec;32(12):2546-59. — View Citation

Brewer ER, Kassim N, Cronin FJ, Dennis BH, Kuczmarski RJ, Haynes S, Graves K. Food group system of analysis with special attention to type and amount of fat--methodology. J Am Diet Assoc. 1987 May;87(5):584-92. — View Citation

Bucher KD, Friedlander Y, Kaplan EB, Namboodiri KK, Kark JD, Eisenberg S, Stein Y, Rifkind BM. Biological and cultural sources of familial resemblance in plasma lipids: a comparison between North America and Israel--the Lipid Research Clinics Program. Genet Epidemiol. 1988;5(1):17-33. — View Citation

Bucher KD, Kaplan EB, Namboodiri KK, Glueck CJ, Laskarzewski P, Rifkind BM. Segregation analysis of low levels of high-density lipoprotein cholesterol in the collaborative Lipid Research Clinics Program Family Study. Am J Hum Genet. 1987 Jun;40(6):489-502. — View Citation

Bush TL, Barrett-Connor E, Cowan LD, Criqui MH, Wallace RB, Suchindran CM, Tyroler HA, Rifkind BM. Cardiovascular mortality and noncontraceptive use of estrogen in women: results from the Lipid Research Clinics Program Follow-up Study. Circulation. 1987 Jun;75(6):1102-9. — View Citation

Bush TL, Cowan LD, Barrett-Connor E, Criqui MH, Karon JM, Wallace RB, Tyroler HA, Rifkind BM. Estrogen use and all-cause mortality. Preliminary results from the Lipid Research Clinics Program Follow-Up Study. JAMA. 1983 Feb 18;249(7):903-6. — View Citation

Cholesterol and triglyceride concentrations in serum/plasma pairs. Clin Chem. 1977 Jan;23(1):60-3. — View Citation

Christensen B, Glueck C, Kwiterovich P, Degroot I, Chase G, Heiss G, Mowery R, Tamir I, Rifkind B. Plasma cholesterol and triglyceride distributions in 13,665 children and adolescents: the Prevalence Study of the Lipid Research Clinics Program. Pediatr Res. 1980 Mar;14(3):194-202. — View Citation

Collaborative US-USSR study on the prevalence of dyslipoproteinemias and ischemic heart disease in American and Soviet populations. Prepared by the US-USSR Steering Committee for Problem Area 1: the pathogenesis of atherosclerosis. Am J Cardiol. 1977 Aug;40(2):260-8. — View Citation

Cowan LD, O'Connell DL, Criqui MH, Barrett-Connor E, Bush TL, Wallace RB. Cancer mortality and lipid and lipoprotein levels. Lipid Research Clinics Program Mortality Follow-up Study. Am J Epidemiol. 1990 Mar;131(3):468-82. — View Citation

Cowan LD, Wallace RB, Barrett-Connor E, Hunninghake D, Pomrehn P, Wahl P, Heiss G. Alterations in clinical chemistry measures associated with oral contraceptive and estrogen use: the Lipid Research Clinics Program Prevalence Study. J Reprod Med. 1982 May;27(5):275-82. — View Citation

Cowan LD, Wilcosky T, Criqui MH, Barrett-Connor E, Suchindran CM, Wallace R, Laskarzewski P, Walden C. Demographic, behavioral, biochemical, and dietary correlates of plasma triglycerides. Lipid Research Clinics Program Prevalence Study. Arteriosclerosis. 1985 Sep-Oct;5(5):466-80. — View Citation

Criqui MH, Cowan LD, Heiss G, Haskell WL, Laskarzewski PM, Chambless LE. Frequency and clustering of nonlipid coronary risk factors in dyslipoproteinemia. The Lipid Research Clinics Program Prevalence Study. Circulation. 1986 Jan;73(1 Pt 2):I40-50. — View Citation

Criqui MH, Cowan LD, Tyroler HA, Bangdiwala S, Heiss G, Wallace RB, Cohn R. Lipoproteins as mediators for the effects of alcohol consumption and cigarette smoking on cardiovascular mortality: results form the Lipid Research Clinics Follow-up Study. Am J Epidemiol. 1987 Oct;126(4):629-37. — View Citation

Criqui MH, Haskell WL, Heiss G, Tyroler HA, Green P, Rubenstein CJ. Predictors of systolic blood pressure response to treadmill exercise: the Lipid Research Clinics Program Prevalence Study. Circulation. 1983 Aug;68(2):225-33. — View Citation

Criqui MH, Mebane I, Wallace RB, Heiss G, Holdbrook MJ. Multivariate correlates of adult blood pressures in nine North American populations: The Lipid Research Clinics Prevalence Study. Prev Med. 1982 Jul;11(4):391-402. — View Citation

Criqui MH, Wallace RB, Heiss G, Mishkel M, Schonfeld G, Jones GT. Cigarette smoking and plasma high-density lipoprotein cholesterol. The Lipid Research Clinics Program Prevalence Study. Circulation. 1980 Nov;62(4 Pt 2):IV70-6. — View Citation

Criqui MH, Wallace RB, Mishkel M, Barrett-Connor E, Heiss G. Alcohol consumption and blood pressure. The lipid research clinics prevalence study. Hypertension. 1981 Sep-Oct;3(5):557-65. — View Citation

Davis CE, Gordon D, LaRosa J, Wood PD, Halperin M. Correlations of plasma high-density lipoprotein cholesterol levels with other plasma lipid and lipoprotein concentrations. Circulation. 1980 Nov;62(4 Pt 2):IV24-30. — View Citation

DeLong DM, DeLong ER, Wood PD, Lippel K, Rifkind BM. A comparison of methods for the estimation of plasma low- and very low-density lipoprotein cholesterol. The Lipid Research Clinics Prevalence Study. JAMA. 1986 Nov 7;256(17):2372-7. — View Citation

Dennis B, Ernst N, Hjortland M, Tillotson J, Grambsch V. The NHLBI nutrition data system. J Am Diet Assoc. 1980 Dec;77(6):641-7. — View Citation

Dennis BH, Haynes SG, Anderson JJ, Liu-Chi SB, Hosking JD, Rifkind BM. Nutrient intakes among selected North American populations in the Lipid Research Clinics Prevalence Study: composition of energy intake. Am J Clin Nutr. 1985 Feb;41(2):312-29. — View Citation

Eisenberg S, Heiss G, Friedlander Y, Rifkind B, Segal P, Williams OD, Stein Y. Comparison of plasma lipids, lipoproteins and dyslipoproteinemia in Israel and the United States. The Lipid Research Clinics Program Prevalence Study. Atherosclerosis. 1986 Jan;59(1):63-74. — View Citation

Ekelund LG, Haskell WL, Johnson JL, Whaley FS, Criqui MH, Sheps DS. Physical fitness as a predictor of cardiovascular mortality in asymptomatic North American men. The Lipid Research Clinics Mortality Follow-up Study. N Engl J Med. 1988 Nov 24;319(21):1379-84. — View Citation

Ekelund LG, Suchindran CM, Karon JM, McMahon RP, Tyroler HA. Black-white differences in exercise blood pressure. The Lipid Research Clinics Program Prevalence Study. Circulation. 1990 May;81(5):1568-74. — View Citation

Ernst N, Fisher M, Smith W, Gordon T, Rifkind BM, Little JA, Mishkel MA, Williams OD. The association of plasma high-density lipoprotein cholesterol with dietary intake and alcohol consumption. The Lipid Research Clinics Prevalence Study. Circulation. 1980 Nov;62(4 Pt 2):IV41-52. — View Citation

Esrey KL, Joseph L, Grover SA. Relationship between dietary intake and coronary heart disease mortality: lipid research clinics prevalence follow-up study. J Clin Epidemiol. 1996 Feb;49(2):211-6. — View Citation

Fisher M, Gordon T. The relation of drinking and smoking habits to diet: the Lipid Research Clinics Prevalence Study. Am J Clin Nutr. 1985 Mar;41(3):623-30. — View Citation

Friedlander Y, Bucher KD, Namboodiri KK, Heiss G, Kark JD, Tyroler HA, Eisenberg S, Stein Y, Rifkind BM. Parent-offspring aggregation of plasma lipids in selected populations in North America and Israel. The Lipid Research Clinics Prevalence Study. Am J Epidemiol. 1987 Aug;126(2):268-79. — View Citation

Glueck CJ, Heiss G, Morrison JA, Khoury P, Moore M. Alcohol intake, cigarette smoking and plasma lipids and lipoproteins in 12--19-year-old children. The Collaborative Lipid Research Clinics Prevalence Study. Circulation. 1981 Sep;64(3 Pt 2):III 48-56. Review. — View Citation

Glueck CJ, Laskarzewski PM, Suchindran CM, Chambless LE, Barrett-Connor E, Stewart P, Heiss G, Tyroler HA. Progeny's lipid and lipoprotein levels by parental mortality. The Lipid Research Clinics Program Prevalence Study. Circulation. 1986 Jan;73(1 Pt 2):I51-61. — View Citation

Glueck CJ, Taylor HL, Jacobs D, Morrison JA, Beaglehole R, Williams OD. Plasma high-density lipoprotein cholesterol: association with measurements of body mass. The Lipid Research Clinics Program Prevalence Study. Circulation. 1980 Nov;62(4 Pt 2):IV-62-9. — View Citation

Glueck CJ, Waldman G, McClish DK, Morrison JA, Khoury P, Larsen R, Salz K, Rifkind BM, Mattson FH. Relationships of nutrient intake to lipids and lipoproteins in 1234 white children. The Lipid Research Clinics Prevalence Study. Arteriosclerosis. 1982 Nov-Dec;2(6):523-36. — View Citation

Goor R, Hosking JD, Dennis BH, Graves KL, Waldman GT, Haynes SG. Nutrient intakes among selected North American populations in the Lipid Research Clinics Prevalence Study: composition of fat intake. Am J Clin Nutr. 1985 Feb;41(2):299-311. — View Citation

Gordon DJ, Ekelund LG, Karon JM, Probstfield JL, Rubenstein C, Sheffield LT, Weissfeld L. Predictive value of the exercise tolerance test for mortality in North American men: the Lipid Research Clinics Mortality Follow-up Study. Circulation. 1986 Aug;74(2):252-61. — View Citation

Gordon DJ, Probstfield JL, Garrison RJ, Neaton JD, Castelli WP, Knoke JD, Jacobs DR Jr, Bangdiwala S, Tyroler HA. High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies. Circulation. 1989 Jan;79(1):8-15. — View Citation

Gordon DJ, Salz KM, Roggenkamp KJ, Franklin FA Jr. Dietary determinants of plasma cholesterol change in the recruitment phase of the Lipid Research Clinics Coronary Primary Prevention Trial. Arteriosclerosis. 1982 Nov-Dec;2(6):537-48. — View Citation

Gordon T, Ernst N, Fisher M, Rifkind BM. Alcohol and high-density lipoprotein cholesterol. Circulation. 1981 Sep;64(3 Pt 2):III 63-7. Review. — View Citation

Gordon T, Fisher M, Ernst N, Rifkind BM. Relation of diet to LDL cholesterol, VLDL cholesterol, and plasma total cholesterol and triglycerides in white adults. The Lipid Research Clinics Prevalence Study. Arteriosclerosis. 1982 Nov-Dec;2(6):502-12. — View Citation

Gordon T, Fisher M, Rifkind BM. Some difficulties inherent in the interpretation of dietary data from free-living populations. Am J Clin Nutr. 1984 Jan;39(1):152-6. — View Citation

Green MS, Heiss G, Rifkind BM, Cooper GR, Williams OD, Tyroler HA. The ratio of plasma high-density lipoprotein cholesterol to total and low-density lipoprotein cholesterol: age-related changes and race and sex differences in selected North American populations. The Lipid Research Clinics Program Prevalence Study. Circulation. 1985 Jul;72(1):93-104. — View Citation

Green P, Owen AR, Namboodiri K, Hewitt D, Williams LR, Elston RC. The Collaborative Lipid Research Clinics Program Family Study: detection of major genes influencing lipid levels by examination of heterogeneity of familial variances. Genet Epidemiol. 1984;1(2):123-41. — View Citation

Green PP, Namboodiri KK, Hannan P, Martin J, Owen AR, Chase GA, Kaplan EB, Williams L, Elston RC. The Collaborative Lipid Research Clinics Program Family Study. III. Transformations and covariate adjustments of lipid and lipoprotein levels. Am J Epidemiol. 1984 Jun;119(6):959-74. — View Citation

Greenberg RA, Green PP, Roggenkamp KJ, Barrett-Connor E, Tyroler HA, Heiss G. The constancy of parent-offspring similarity of total cholesterol throughout childhood and early adult life. The Lipid Research Clinics Program Prevalence Study. J Chronic Dis. 1984;37(11):833-8. — View Citation

Halfon ST, Friedlander Y, Halperin G, Harlap S, Dennis BH, Moore MH, Mowery RL, Tyroler HA, Williams OD. Plasma high-density lipoprotein cholesterol, total cholesterol and triglyceride levels in 17-year-old Jewish residents of Jerusalem: a preliminary report. The Lipid Research Clinics Program Prevalence Study. Circulation. 1980 Nov;62(4 Pt 2):IV93-8. — View Citation

Haskell WL, Taylor HL, Wood PD, Schrott H, Heiss G. Strenuous physical activity, treadmill exercise test performance and plasma high-density lipoprotein cholesterol. The Lipid Research Clinics Program Prevalence Study. Circulation. 1980 Nov;62(4 Pt 2):IV53-61. — View Citation

Heiss G, Haskell W, Mowery R, Criqui MH, Brockway M, Tyroler HA. Plasma high-density lipoprotein cholesterol and socioeconomic status. The Lipid Research Clinics Program Prevalence Study. Circulation. 1980 Nov;62(4 Pt 2):IV108-15. — View Citation

Heiss G, Johnson NJ, Reiland S, Davis CE, Tyroler HA. The epidemiology of plasma high-density lipoprotein cholesterol levels. The Lipid Research Clinics Program Prevalence Study. Summary. Circulation. 1980 Nov;62(4 Pt 2):IV116-36. — View Citation

Heiss G, Tamir I, Davis CE, Tyroler HA, Rifkand BM, Schonfeld G, Jacobs D, Frantz ID Jr. Lipoprotein-cholesterol distributions in selected North American populations: the lipid research clinics program prevalence study. Circulation. 1980 Feb;61(2):302-15. — View Citation

Heuch I, Namboodiri KK, Green PP, Kaplan EB, Laskarzewski P, Glueck CJ, Elston RC. A multivariate analysis of familial associations of lipoprotein levels in the Lipid Research Clinics Collaborative Family Study: I. Familial correlation and regression analyses. Genet Epidemiol. 1985;2(3):283-300. — View Citation

Hunninghake D, Wallace RB, Reiland S, Barrett-Connor E, Wahl P, Hoover J, Heiss G. Alterations of plasma lipid and lipoprotein levels associated with benzodiazepine use--the LRC Program Prevalence Study. Atherosclerosis. 1981 Oct;40(2):159-65. — View Citation

Ingram DD, Thorn MD, Stinnett SS, Deev AD. U.S.S.R. and U.S. nutrient intake, plasma lipids, and lipoproteins in men ages 40-59 sampled from Lipid Research Clinics populations. Prev Med. 1985 May;14(3):264-71. — View Citation

Jacobs DR Jr, Barrett-Connor E. Retest reliability of plasma cholesterol and triglyceride. The Lipid Research Clinics Prevalence Study. Am J Epidemiol. 1982 Dec;116(6):878-85. — View Citation

Jacobs DR Jr, Mebane IL, Bangdiwala SI, Criqui MH, Tyroler HA. High density lipoprotein cholesterol as a predictor of cardiovascular disease mortality in men and women: the follow-up study of the Lipid Research Clinics Prevalence Study. Am J Epidemiol. 1990 Jan;131(1):32-47. — View Citation

Kalsbeek WD, Kral KM, Wallace RB, Rifkind BM. Comparing mean levels of total cholesterol from visit 2 of the Lipid Research Clinics Prevalence Study with the second National Health and Nutrition Examination Survey. Am J Epidemiol. 1988 Nov;128(5):1038-53. — View Citation

Karlin S, Williams PT, Farquhar JW, Barrett-Connor E, Hoover J, Wahl PW, Haskell WL, Bergelin RO, Suarez L. Association arrays for the study of familial height, weight, lipid, and lipoprotein similarity in three West Coast populations. Am J Epidemiol. 1982 Dec;116(6):1001-21. — View Citation

Kaufmann NA, Dennis BH, Heiss G, Friedlander Y, Kark JD, Stein Y. Comparison of nutrient intakes of selected populations in the United States and Israel: the Lipid Research Clinics prevalence study. Am J Clin Nutr. 1986 Apr;43(4):604-20. — View Citation

Knopp RH, Walden CE, Heiss G, Johnson JL, Wahl PW. Prevalence and clinical correlates of beta-migrating very-low-density lipoprotein. Lipid Research Clinics Program Prevalence Study. Am J Med. 1986 Sep;81(3):493-502. — View Citation

Kuba K, Lippel K, Frantz ID Jr. Four electrophoretic methods compared for diagnosis of type III hyperlipoproteinemia. Clin Chem. 1979 Aug;25(8):1471-5. — View Citation

Kuczmarski RJ, Brewer ER, Cronin FJ, Dennis B, Graves K, Haynes S. Food choices among white adolescents: the Lipid Research Clinics Prevalence Study. Pediatr Res. 1986 Apr;20(4):309-15. — View Citation

Kwiterovich PO Jr, Heiss G, Johnson N, Chase GA, Tamir I, Rifkind B. Assessment of plasma total cholesterol as a test to detect elevated low density (beta) lipoprotein cholesterol levels (type IIa hyperlipoproteinemia) in young subjects from a population-based sample. Am J Epidemiol. 1982 Feb;115(2):192-204. — View Citation

Kwiterovich PO Jr, Stewart P, Probstfield JL, Stinnett S, Chambless LE, Chase GA, Jacobs DR, Morrison JA. Detection of dyslipoproteinemia with the use of plasma total cholesterol and triglyceride as screening tests. The Lipid Research Clinics Program Prevalence Study. Circulation. 1986 Jan;73(1 Pt 2):I30-9. — View Citation

LaRosa JC, Chambless LE, Criqui MH, Frantz ID, Glueck CJ, Heiss G, Morrison JA. Patterns of dyslipoproteinemia in selected North American populations. The Lipid Research Clinics Program Prevalence Study. Circulation. 1986 Jan;73(1 Pt 2):I12-29. — View Citation

LaRosa JC, Levy RI, Hazzard WR. Some clinical implications of the results of the Lipid Research Clinics Program Prevalence Study. Circulation. 1986 Jan;73(1 Pt 2):I126-33. — View Citation

Levy RI, Rifkind BM. The structure, function and metabolism of high-density lipoproteins: A status report. Circulation. 1980 Nov;62(4 Pt 2):IV4-8. Review. — View Citation

Lipid Research Clinics Program: Manual of Laboratory Operations, vol. 1. Lipid and Lipoprotein Analysis. Washington, DC., U.S. Government Printing Office, DHEW Publication No. (NIH) 75-628, May 1974

Lippel K, Ahmed S, Albers JJ, Bachorik P, Cooper G, Helms R, Williams J. Analytical performance and comparability of the determination of cholesterol by 12 Lipid-Research Clinics. Clin Chem. 1977 Sep;23(9):1744-52. — View Citation

Lippel K, Ahmed S, Albers JJ, Bachorik P, Muesing R, Winn C. External quality-control survey of cholesterol analyses performed by 12 lipid research clinics. Clin Chem. 1978 Sep;24(9):1477-84. — View Citation

Little JA, Graves K, Suchindran CM, Milner J, McGuire V, Beaton G, Feather T, Mattson FH, Christiansen D, Williams OD. Customary diet, anthropometry, and dyslipoproteinemia in selected North American populations. The Lipid Research Clinics Program Prevalence Study. Circulation. 1986 Jan;73(1 Pt 2):I80-90. — View Citation

Manual of Laboratory Operations: LRC Program, Vol. 1: Lipid and Lipoprotein Analysis. DHEW Publication No. (NIH) 75-628. May 1974. Revised version issued October, 1982

Mora S, Redberg RF, Cui Y, Whiteman MK, Flaws JA, Sharrett AR, Blumenthal RS. Ability of exercise testing to predict cardiovascular and all-cause death in asymptomatic women: a 20-year follow-up of the lipid research clinics prevalence study. JAMA. 2003 Sep 24;290(12):1600-7. — View Citation

Morrison JA, Khoury P, Laskarzewski P, Gartside P, Moore M, Heiss G, Glueck CJ. Hyperalphalipoproteinemia in hypercholesterolemic adults and children. Trans Assoc Am Physicians. 1980;93:230-43. — View Citation

Morrison JA, Namboodiri K, Green P, Martin J, Glueck CJ. Familial aggregation of lipids and lipoproteins and early identification of dyslipoproteinemia. The Collaborative Lipid Research Clinics Family Study. JAMA. 1983 Oct 14;250(14):1860-8. — View Citation

Namboodiri KK, Green PP, Kaplan EB, Morrison JA, Chase GA, Elston RC, Owen AR, Rifkind BM, Glueck CJ, Tyroler HA. The Collaborative Lipid Research Clinics Program Family Study. IV. Familial associations of plasma lipids and lipoproteins. Am J Epidemiol. 1984 Jun;119(6):975-96. — View Citation

Namboodiri KK, Green PP, Kaplan EB, Tyroler HA, Morrison JA, Chase GA, Elston RC, Rifkind BM, Glueck CJ. Family aggregation of high density lipoprotein cholesterol. Collaborative lipid research clinics program family study. Arteriosclerosis. 1983 Nov-Dec;3(6):616-26. — View Citation

Namboodiri KK, Green PP, Walden C, Kaplan EB, Dawson D, Kelly K, Maciolowski M, Morrison JA, Elston RC, Austin M, et al. The Collaborative Lipid Research Clinics Program Family Study. II. Response rates, representativeness of the sample, and stability of lipid and lipoprotein levels. Am J Epidemiol. 1984 Jun;119(6):944-58. — View Citation

Namboodiri KK, Kaplan EB, Heuch I, Elston RC, Green PP, Rao DC, Laskarzewski P, Glueck CJ, Rifkind BM. The Collaborative Lipid Research Clinics Family Study: biological and cultural determinants of familial resemblance for plasma lipids and lipoproteins. Genet Epidemiol. 1985;2(3):227-54. — View Citation

Nutrient intake and its association with high-density lipoprotein and low-density lipoprotein cholesterol in selected US and USSR subpopulations. The US-USSR Steering Committee for Problem Area I: The pathogenesis of atherosclerosis. Am J Clin Nutr. 1984 Jun;39(6):942-52. — View Citation

Patten RL, Hewitt D, Waldman GT, Jones G, Little JA. Associations of plasma high-density lipoprotein cholesterol with clinical chemistry data. Circulation. 1980 Nov;62(4 Pt 2):IV31-41. — View Citation

Pekkanen J, Linn S, Heiss G, Suchindran CM, Leon A, Rifkind BM, Tyroler HA. Ten-year mortality from cardiovascular disease in relation to cholesterol level among men with and without preexisting cardiovascular disease. N Engl J Med. 1990 Jun 14;322(24):1700-7. — View Citation

Plasma lipid distributions in selected North American populations: the Lipid Research Clinics Program Prevalence Study. The Lipid Research Clinics Program Epidemiology Committee. Circulation. 1979 Aug;60(2):427-39. — View Citation

Pomrehn P, Duncan B, Weissfeld L, Wallace RB, Barnes R, Heiss G, Ekelund LG, Criqui MH, Johnson N, Chambless LE. The association of dyslipoproteinemia with symptoms and signs of peripheral arterial disease. The Lipid Research Clinics Program Prevalence Study. Circulation. 1986 Jan;73(1 Pt 2):I100-7. — View Citation

Prewitt TE, Haynes SG, Graves K, Haines PS, Tyroler HA. Nutrient intake, lipids, and lipoprotein cholesterols in black and white children: the Lipid Research Clinics Prevalence Study. Prev Med. 1988 May;17(3):247-62. — View Citation

Rifkind BM, for the Alcohol-Nutrition, Anthropometry, and Lipoprotein Working Groups of the LRC Program Prevalence Study: Nutrient-High-Density-Lipoprotein Relationships: An Overview. Proceedings of the US-Italy Symposium on Nutrition and Cardiovascular Diseases, Progress in Biochemical Pharmacology (Vol. 19), Hegyeli RJ, (Ed), Karger, Basel, pp. 89-109, 1983

Rifkind BM, Heiss G, Tyroler HA, Williams OD: The Epidemiology of High Density Lipoproteins: The Lipid Research Clinics Program Prevalence Study. In: Proceedings of the Fourth International Meeting on Atherosclerosis - Atherosclerosis Clinical Evaluation and Therapy. Lenzi S, Descovich GC (Eds) Lancaster, England: MTP Press, Ltd., pp. 61-75, 1982

Rifkind BM, LaRosa J. Heiss G: The Prevalence of Hyperlipidemia in Selected North American Populations. In: Atherosclerosis V. Proceedings of the Fifth International Symposium on Atherosclerosis (Gotto AM, Ed) New York:Springer-Verlag, pp. 264-267; 829-830, 1980

Rifkind BM, Segal P. Lipid Research Clinics Program reference values for hyperlipidemia and hypolipidemia. JAMA. 1983 Oct 14;250(14):1869-72. — View Citation

Rifkind BM, Tamir I, Heiss G, Wallace RB, Tyroler HA. Distribution of high density and other lipoproteins in selected LRC prevalence study populations: a brief survey. Lipids. 1979 Jan;14(1):105-12. — View Citation

Rifkind BM, Tamir I, Heiss G.: Preliminary High-Density Lipoprotein Findings: The Lipid Research Clinics Program. In: Gotto AM, Jr. Miller NE, Oliver MF, (Eds), High Density Lipoproteins and Atherosclerosis. Amsterdam: Elsevier/North Holland Biomedical press, pp. 109-119, 1978

Rubenstein C, Romhilt D, Segal P, Heiss G, Chambless LE, Boyle KE, Ekelund LG, Adolph R, Sheffield LT. Dyslipoproteinemias and manifestations of coronary heart disease. The Lipid Research Clinics Program Prevalence Study. Circulation. 1986 Jan;73(1 Pt 2):I91-9. — View Citation

Salz KM, Tamir I, Ernst N, Kwiterovich P, Glueck C, Christensen B, Larsen R, Pirhonen D, Prewitt TE, Scott LW. Selected nutrient intakes of free-living white children ages 6-19 years. The Lipid Research Clinics Program Prevalence Study. Pediatr Res. 1983 Feb;17(2):124-30. — View Citation

Schwarz W, Trost DC, Reiland SL, Rifkind BM, Heiss G. Correlates of low density lipoprotein cholesterol: associations with physical, chemical, dietary, and behavioral characteristics. Arteriosclerosis. 1982 Nov-Dec;2(6):513-22. — View Citation

Segal P, Insull W Jr, Chambless LE, Stinnett S, LaRosa JC, Weissfeld L, Halfon S, Kwiterovitch PO Jr, Little JA. The association of dyslipoproteinemia with corneal arcus and xanthelasma. The Lipid Research Clinics Program Prevalence Study. Circulation. 1986 Jan;73(1 Pt 2):I108-18. — View Citation

Segal P, Rifkind BM, Schull WJ. Genetic factors in lipoprotein variation. Epidemiol Rev. 1982;4:137-60. Review. — View Citation

Shalnova S, Shestov DB, Ekelund LG, Abernathy JR, Plavinskaya S, Thomas RP, Williams DH, Deev A, Davis CE. Blood pressure and heart rate response during exercise in men and women in the USA and Russia lipid research clinics prevalence study. Atherosclerosis. 1996 Apr 26;122(1):47-57. — View Citation

Sheffield LT, Haskell W, Heiss G, Kioschos M, Leon A, Roitman D, Schrott H: Safety of Exercise Testing Volunteer Subjects. The Lipid Research Clinics Prevalence Study Experience. J Cardiac Rehab 2(5):395-400, 1982

Tamir I, Heiss G, Glueck CJ, Christensen B, Kwiterovich P, Rifkind BM. Lipid and lipoprotein distributions in white children ages 6-19 yr. The Lipid Research Clinics Program Prevalence Study. J Chronic Dis. 1981;34(1):27-39. — View Citation

The Collaborative Lipid Research Clinics Program Family Study. I. Study design and description of data. Am J Epidemiol. 1984 Jun;119(6):931-43. — View Citation

The Lipid Research Clinics Population Studies Data Book. Volume I. The Prevalence Study. U.S. Department of Health and Human Services. NIH Publication No. 80-1527, July 1980

The Lipid Research Clinics Population Studies Data Book. Volume II. The Prevalence Study - Nutrient Intake. U.S. Department of Health and Human Services. NIH Publication No. 82-2014, September 1982

The Lipid Research Clinics Population Studies Data Book. Volume III. The USSR First Prevalence Study. US Department of Health and Human Services. NIH Publication No.87-2727, November 1986

The Lipid Research Clinics Population Studies Data Book. Volume IV. The USSR Second Prevalence Study. US Department of Health and Human Services. NIH Publication No.90-2995, June 1990

Tyroler HA, Anderson T, Chase G, Ellis L, Mowery R, Valulick D: The Lipid Research Clinics Population-Based Family Study. In: Genetic Analysis of Common Diseases: Applications to Predictive Factors in Coronary Disease. Sing C, Skolnick M, (Eds) New York: Alan Liss, pp 647-652, 1979

Tyroler HA, Glueck CJ, Christensen B, Kwiterovich PO Jr. Plasma high-density lipoprotein cholesterol comparisons in black and white populations. The Lipid Research Clinics Program Prevalence Study. Circulation. 1980 Nov;62(4 Pt 2):IV99-107. — View Citation

Tyroler HA. Epidemiology of plasma high-density lipoprotein cholesterol levels. The Lipid Research Clinics Program Prevalence Study. Introduction. Circulation. 1980 Nov;62(4 Pt 2):IV1-3. — View Citation

US-USSR Steering Committee for Problem Area 1: A Comparison of High Blood Pressure Prevalence and Treatment Status in Selected US and USSR Populations. The Pathogenesis of Atherosclerosis. In: First Joint US-USSR Symposium on Hypertension, Sochi, USSR, U.S. Department of Health, Education, and Welfare, NIH Publication No. 79-1272, 432-433, August, 1979

US-USSR Steering Committee for Problem Area 1: US-USSR First Lipoprotein Symposium. Laboratory Research Joint Population Studies, Leningrad, USSR. The Pathogenesis of Atherosclerosis. U.S. Department of Health and Human Services. NIH Publication No. 83-1966, November 1982

Wahl P, Walden C, Knopp R, Hoover J, Wallace R, Heiss G, Rifkind B. Effect of estrogen/progestin potency on lipid/lipoprotein cholesterol. N Engl J Med. 1983 Apr 14;308(15):862-7. — View Citation

Walden CE, Knopp RH, Johnson JL, Heiss G, Wahl PW, Hoover JJ. Effect of estrogen/progestin potency on clinical chemistry measures. The Lipid Research Clinics Program Prevalence Study. Am J Epidemiol. 1986 Mar;123(3):517-31. — View Citation

Wallace RB, Barrett-Connor E, Criqui M, Wahl P, Hoover J, Hunninghake D, Heiss G. Alteration in blood pressures associated with combined alcohol and oral contraceptive use-the lipid research clinics prevalence study. J Chronic Dis. 1982;35(4):251-7. — View Citation

Wallace RB, Heiss G, Burrows B, Graves K. Contrasting diet and body mass among users and nonusers of oral contraceptives and exogenous estrogens: the Lipid Research Clinics Program Prevalence Study. Am J Epidemiol. 1987 May;125(5):854-9. — View Citation

Wallace RB, Hoover J, Barrett-Connor E, Rifkind BM, Hunninghake DB, Mackenthun A, Heiss G. Altered plasma lipid and lipoprotein levels associated with oral contraceptive and oestrogen use. Report from the Medications Working Group of the Lipid Research Clinics Program. Lancet. 1979 Jul 21;2(8134):112-5. — View Citation

Wallace RB, Hoover J, Sandler D, Rifking BM, Tyroler HA. Altered plasma-lipids associated with oral contraceptive or oestrogen consumption. The Lipid Research Clinic Program. Lancet. 1977 Jul 2;2(8027):11-4. — View Citation

Wallace RB, Hunninghake DB, Chambless LE, Heiss G, Wahl P, Barrett-Connor E. A screening survey of dyslipoproteinemias associated with prescription drug use. The Lipid Research Clinics Program Prevalence Study. Circulation. 1986 Jan;73(1 Pt 2):I70-9. — View Citation

Wallace RB, Hunninghake DB, Reiland S, Barrett-Connor E, Mackenthun A, Hoover J, Wahl P. Alterations of plasma high-density lipoprotein cholesterol levels associated with consumption of selected medications. The Lipid Research Clinics Program Prevalence Study. Circulation. 1980 Nov;62(4 Pt 2):IV77-82. — View Citation

Wallace RB, Lynch CF, Pomrehn PR, Criqui MH, Heiss G. Alcohol and hypertension: epidemiologic and experimental considerations. The Lipid Research Clinics Program. Circulation. 1981 Sep;64(3 Pt 2):III 41-7. Review. — View Citation

Wallace RB, Pomrehn P, Heiss G, Chambless LE, Johnson N, Patten R, Lippel K, Rifkind BM. Alterations in clinical chemistry levels associated with the dyslipoproteinemias. The Lipid Research Clinics Program Prevalence Study. Circulation. 1986 Jan;73(1 Pt 2):I62-9. — View Citation

Wallace RB, Tamir I, Heiss G, Rifkind BM, Christensen B, Glueck CJ. Plasma lipids, lipoproteins, and blood pressure in female adolescents using oral contraceptives. J Pediatr. 1979 Dec;95(6):1055-9. — View Citation

Warnick GR, Albers JJ, Bachorik PS, Turner JD, Garcia C, Breckinridge C, Kuba K, McNeely S, Hillerman G, King P, Muesing R, Most B, Lippel K. Multilaboratory evaluation of an ultrafiltration procedure for high density lipoprotein cholesterol quantification in turbid heparin-manganese supernates. J Lipid Res. 1981 Aug;22(6):1015-20. — View Citation

Wilcosky T, Harris R, Weissfeld L. The prevalence and correlates of Rose Questionnaire angina among women and men in the Lipid Research Clinics Program Prevalence Study population. Am J Epidemiol. 1987 Mar;125(3):400-9. — View Citation

Wilcosky T, Hyde J, Anderson JJ, Bangdiwala S, Duncan B. Obesity and mortality in the Lipid Research Clinics Program Follow-up Study. J Clin Epidemiol. 1990;43(8):743-52. — View Citation

Wilcosky TC, Kwiterovich PO Jr, Glueck CJ, Suchindran CM, Laskarzewski P, Christensen B, Tyroler HA. Dyslipoproteinemia in black participants. The Lipid Research Clinics Program Prevalence Study. Circulation. 1986 Jan;73(1 Pt 2):I119-25. — View Citation

Williams OD, Heiss G, Beaglehole R, Dennis B, Bazzarre T, Tyroler HA: Hyperlipidemia and Nutrition: Data Base and Trends. Atherosclerosis Reviews 7:145-156, 1980

Williams OD, Heiss G., Beaglehole R, Dennis B, Bazzarre T, and Tyroler HA: Hyperlipidemia and Nutrition - Data Base and Trends. Atherosclerosis Reviews 7:145-156, 1980

Williams OD, Mowery RL, Waldman GT. Common methods, different populations. The Lipid Research Clinics Program Prevalence Study. Circulation. 1980 Nov;62(4 Pt 2):IV18-23. — View Citation

Williams OD, Rywik SL, Tyroler HA, Sznajd J, McClish DK, Ingram D, Maciolowski M: The U.S. - Polish Pilot Study. In: USA-Poland Symposium, Ischemic Heart Disease. U.S. Department of Health and Human Services. NIH Publication No. 82-1273, pp. 1-8 March 1982

Williams OD, Stinnett S, Chambless LE, Boyle KE, Bachorik PS, Albers JJ, Lippel K. Populations and methods for assessing dyslipoproteinemia and its correlates. The Lipid Research Clinics Program Prevalence Study. Circulation. 1986 Jan;73(1 Pt 2):I4-11. — View Citation

Wood PD, Bachorik PS, Albers JJ, Stewart CC, Winn C, Lippel K. Effects of sample aging on total cholesterol values determined by the automated ferric chloride-sulfuric acid and Liebermann-Burchard procedures. Clin Chem. 1980 Apr;26(5):592-7. — View Citation

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