Cardiovascular Diseases Clinical Trial
To assess exercise training adherence and compliance over two years in subjects who were at relatively high risk for coronary artery disease. Also, to test strategies for improving adherence and compliance and to assess the effect of exercise training.
BACKGROUND:
Regular physical exercise is associated with lower coronary heart disease mortality,
favorably affects coronary risk factors, and increases cardiovascular functional capacity.
Fewer than one-third of Americans engage in regular physical exercise and only 20 percent of
men and 10 percent of women over age 45 do so. This is largely because effective strategies
for increasing the exercise habit in a broadly-based segment of Americans have not been
developed. This study applied physiological and behavioral knowledge derived in numerous
laboratories over the past 10-15 years to a clinical setting.
DESIGN NARRATIVE:
Following stratification by gender and cigarette smoking status, subjects were randomized to
one of four groups: home exercise of moderate intensity which was individually monitored;
home exercise of high intensity which was individually monitored; exercise of high intensity
which was group supervised; and a no program control group. The intervention program was
conducted for one year followed by a one-year maintenance program. Main outcome measures
included treadmill exercise test performance, exercise participation rates, and heart
disease risk factors. Variables measured over two years included plasma lipids,
lipoproteins, apoproteins, lipase activity, glucose and insulin, sex hormones,
cardiovascular reactivity to psychological stress, cigarette smoking, nutrient intake,
psychological status, and cardiovascular functional capacity.
;
Allocation: Randomized, Primary Purpose: Prevention
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