Breast Cancer Clinical Trial
Official title:
Neoadjuvant and Adjuvant Olaparib Plus Pembrolizumab Following Platinum Based Chemotherapy Plus Pembrolizumab for Germline BRCA Mutated Triple Negative Breast Cancer (WJOG14020B)
This is a Phase II, single-arm, open label study to evaluate Olaparib plus Pembrolizumab following platinum-based chemotherapy plus Pembrolizumab as neoadjuvant therapy for germline BRCA (gBRCA) 1/2 mutated triple negative breast cancer (TNBC). Pembrolizumab in combination with weekly paclitaxel and carboplatin (treatment 1) is followed by Pembrolizumab in combination with Olaparib (treatment 2) in neoadjuvant setting and Pembrolizumab in combination with Olaparib in adjuvant setting will be studied
n/a
NCT number | NCT05485766 |
Study type | Interventional |
Source | Okayama University |
Contact | Yuko Takahashi, MD., PhD. |
Phone | +81-086-223-7151 |
[email protected] | |
Status | Not yet recruiting |
Phase | Phase 2 |
Start date | October 1, 2022 |
Completion date | September 30, 2027 |
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