Dendritic Cell Therapy for Brain Metastases From Breast- or Lung Cancer

Status Not yet recruiting

Clinical Trial Summary

The study will use an Ommaya reservoir that drains into brain metastases to deliver activated, autolous dendritic cells to the tumor lesion, for patients who are 18 - 75 years old who have brain metastases from either lung cancer or breast cancer. The primary objective of the study is to evaluate the safety and feasibility of administering DCVax-Direct to patients with metastatic tumors in the brain. The secondary objectives are to determine tumor response, the rate of intracranial recurrence (IR), the rate of neurologic deaths, decline in neuro-cognitive functioning and overall survival. Approximately 10 patients with injectable metastatic brain tumors will be enrolled initially in a dose escalation scheme, with the expectation to enroll a total of 24 patients.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03638765
Study type	Interventional
Source	Northwest Biotherapeutics
Contact	Marnix L Bosch, PhD
Phone	2404979022
Email	marnix@nwbio.com
Status	Not yet recruiting
Phase	Phase 1
Start date	November 2018
Completion date	December 2020

View Details

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