Breast Cancer Clinical Trial
Official title:
Immunotherapy of Colon Cancer With Autologous Perchloric Soluble Tumors Extracts
RATIONALE: Immunotherapy uses different ways to stimulate the immune system and stop cancer
cells from growing. Immunotherapy biological extracts may be useful as adjuvant therapy in
treating patients who have had surgery for breast cancer, colon cancer, or melanoma.
PURPOSE: Phase III trial to study the effectiveness of Corynebacterium granulosum extract as
maintenance immunotherapy following surgery in treating patients with breast cancer, colon
cancer, or melanoma.
OBJECTIVES:
- Determine the survival of patients with colon cancer, breast cancer, or melanoma with
minimal residual disease after surgical resection treated with maintenance
immunotherapy using Corynebacterium granulosum P40.
- Determine leucocyte adherence inhibition, an indication of metastases, over time in
patients treated with this regimen.
OUTLINE: This is a multicenter study. Patients are stratified by center and are matched with
case-controls by disease type and stage.
Beginning 2 weeks after surgical resection, patients receive Corynebacterium granulosum P40
subcutaneously weekly for 6 weeks, followed by rest for 3 months. Treatment continues for
life.
Patients are followed for survival.
PROJECTED ACCRUAL: Not specified
;
Primary Purpose: Treatment
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