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Brain Injuries, Traumatic clinical trials

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NCT ID: NCT03797378 Active, not recruiting - Stroke Clinical Trials

Movement-2-Music: Lakeshore Examination of Activity, Disability, and Exercise Response Study

M2M LEADERS
Start date: August 9, 2019
Phase: N/A
Study type: Interventional

The purpose of this study is to test the effects of an innovative exercise program referred to as movement-2-music (M2M) on health and fitness outcomes in adults with physical/mobility disabilities. One hundred and eight participants with physical/mobility disabilities will be recruited and randomly enrolled into one of two groups: a) M2M or b) waitlist control. The primary aim of this study is to determine the effects of a 12-week M2M program on health and fitness in participants with physical/mobility disabilities who are in one of three functional mobility groups: 1) Group I - only able to exercise while sitting, 2) Group II - able to exercise sitting and standing with/without support, and 3) Group III - able to exercise one side of the body more than the other side. The second aim is to compare the observed effects of the program in this study to a previous M2M study that groups participants based on disability type. The third aim of this study is to test whether adherence (defined as attendance to the 12-week program) affects the effects of M2M in participants with physical/mobility disabilities. The potential influences of different functional mobility and disabilities of participants on how the program affects participants' health and fitness outcomes will also be tested. **In response to COVID-19, the 12-week M2M intervention and all assessments have been modified from being delivered in-person at Lakeshore Foundation to being delivered remotely in real-time through videoconferencing technology.**

NCT ID: NCT03795896 Active, not recruiting - Clinical trials for Traumatic Brain Injury

Ocular Ultrasonography as a Tool for Monitoring the Management of Traumatic Brain Injury

Start date: September 1, 2018
Phase: N/A
Study type: Interventional

Raised intracranial pressure (ICP) is a common and life threatening condition especially in patients with traumatic brain injury.There are many methods for monitoring the increased (ICP) either invasive or non- invasive ,but the gold standard is invasive method. Optic nerve sheath ultrasonography provides a very promising bedside tool for detection of increased ICP. This study will monitor the dynamic changes of intracranial pressure by optic nerve sheath diameter (ONSD) in response to mannitol osmotherapy

NCT ID: NCT03649958 Active, not recruiting - Insomnia Clinical Trials

Neurotechnology Following Traumatic Brain Injury

Cereset
Start date: August 28, 2018
Phase: N/A
Study type: Interventional

This two-part study seeks to improve symptoms such as pain and sleep problems after concussion, or mild traumatic brain injury (mTBI). Study I evaluates symptoms of mTBI through a series of 10 office sessions in which musical tones are echoed, or mirrored back in real time, to reflect one's own brain activity. Those who take part in the study will be randomly assigned to receive either tones that are based on their brain activity/brainwaves, or random tones. Study II evaluates symptoms of mTBI through either 10 office sessions of the same acoustic stimulation linked to brain activity/brainwaves as Study I compared to 5 office sessions of acoustic stimulation plus intermittent very low level electrical stimulation of the scalp linked to brain activity.

NCT ID: NCT03608722 Active, not recruiting - Dementia Clinical Trials

Video Games to Track Cognitive Health

Start date: November 2015
Phase: N/A
Study type: Interventional

The purpose of this study is to assess cognitive function using a rapid, portable, computerized neurocognitive testing device in a wide variety of clinical settings.

NCT ID: NCT03600324 Active, not recruiting - Clinical trials for Mild Traumatic Brain Injury

Randomized Controlled Trial for Vestibular Treatment in Concussion

Start date: February 26, 2020
Phase: N/A
Study type: Interventional

A prospective, single-blind, four-group multi-center randomized controlled trial (RCT) of targeted rehabilitation exercises for vestibular symptoms and impairments (T-REV) in civilians with mild traumatic brain injury (mTBI) will be conducted at the University of Pittsburgh Medical Center Sports Medicine Concussion Program (UPitt). The four treatment groups will consist of the factorial combinations of low (30%) and high (70%) intensity of exercise crossed with low (12-18 min, 1x/day) and high (12-18 min, 2x/day) frequency. A total of 125 participants aged 18-50 years will be enrolled across years 1-4, with approximately 100 participants completing the whole study. After potential participants with mTBI are screened for the vestibular clinical profile, using domain-specific tests and measures, and enrolled into the study, participants will complete primary and secondary outcome measures and receive a home exercise program that a) targets participants individual deficits, and b) is of the appropriate intensity and frequency for the participant's randomly assigned treatment group. Participants will return for in-clinic visits once per week to receive treatment and progress assigned exercises.

NCT ID: NCT03594734 Active, not recruiting - Clinical trials for Traumatic Brain Injury

Group Lifestyle Balanceā„¢ for Individuals With Traumatic Brain Injury (GLB-TBI)

Start date: January 8, 2019
Phase: N/A
Study type: Interventional

The purpose of this RCT is to examine the efficacy of a Group Lifestyle Balanceā„¢ (GLB) program adapted for people with traumatic brain injury (TBI) on primary (weight) and secondary outcomes at 3, 6, 12, and 18 months from enrollment into the program.

NCT ID: NCT03582579 Active, not recruiting - Clinical trials for Mild Traumatic Brain Injury

Enhancing Brain Training With Virtual Reality

Start date: June 27, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the effectiveness of brain training in a Virtual Reality set up in neurotypical populations as well as in the traumatic brain injury population.

NCT ID: NCT03479970 Active, not recruiting - Cognition Disorders Clinical Trials

Rehabilitation of Social Cognition in Subjects With Traumatic Brain Injury

SOCCER
Start date: January 2, 2018
Phase: N/A
Study type: Interventional

In the present study the investigators aim to analyze the performance in a battery of social cognition tests of subjects with traumatic brain injury. On the other hand, the effectiveness of a computerized rehabilitation program designed to improve these deficits will be tested, as well as the relationship between social cognition and executive functioning.

NCT ID: NCT03479541 Active, not recruiting - Quality of Life Clinical Trials

Can Early Initiation of Rehabilitation With Wearable Sensor Technology Improve Outcomes in mTBI?

Start date: July 15, 2018
Phase: N/A
Study type: Interventional

Every year 1.7 million people sustain a traumatic brain injury (TBI) in the United States and of these, 84 % are considered mild TBI (mTBI). mTBI is common both in civilian and military populations and can be debilitating if symptoms do not resolve after injury. Balance problems are one of the most common complaints after sustaining a mTBI and often prevent individuals from returning to their previous quality of life. However, the investigators currently lack clear guidelines on when to initiate physical therapy rehabilitation and it is unclear if early physical therapy is beneficial. The investigators believe that the underlying problem of imbalance results from damage to parts of the brain responsible for interpreting sensory information for balance control. The investigators hypothesize that retraining the brain early, as opposed to months after injury, to correctly interpret sensory information will improve recovery. The investigators also believe this retraining is limited when rehabilitation exercises are performed incorrectly, and that performance feedback from wearable sensors, can improve balance rehabilitation. There are three objectives of this study: 1) to determine how the timing of rehabilitation affects outcomes after mTBI; 2) to determine if home monitoring of balance exercises using wearable sensors improves outcomes; and 3) to develop a novel feedback system using wearable sensors to provide the physical therapist information, in real-time during training, about quality of head and trunk movements during prescribed exercises. The findings from this research could be very readily adopted into military protocols for post-mTBI care and have the potential to produce better balance rehabilitation and quality of life for mTBI patients and their families.

NCT ID: NCT03441867 Active, not recruiting - Epilepsy Clinical Trials

Neuroimaging Biomarker for Seizures

NIBMSZS
Start date: September 15, 2017
Phase: N/A
Study type: Interventional

This multi-site study will examine patients with epilepsy (ES) following head injury [i.e., posttraumatic epilepsy (PTE)] and posttraumatic psychogenic Non-epileptic seizures (PNES) and will compare them to patients with traumatic brain injury (TBI) who do not have seizures using functional neuroimaging.