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Atrial Fibrillation clinical trials

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NCT ID: NCT01513031 Terminated - Atrial Fibrillation Clinical Trials

Determination of Rates and Reasons for Non-Adherence to Anti-Arrhythmic Therapy for Atrial Fibrillation

Start date: January 2012
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine if follow-up by a pharmacist over the telephone improves adherence and short term clinical outcomes in the patient with atrial fibrillation prescribed an oral anti-arrhythmic medication. This study will also identify the reasons people stop taking their anti-arrhythmic therapy. A pharmacist will provide medication counseling about their anti-arrhythmic therapy, then will follow-up by telephone on a monthly basis to assess adherence over one year.

NCT ID: NCT01512381 Terminated - Heart Failure Clinical Trials

Atrioventricular Node Ablation in Patients With Atrial Fibrillation and Moderate Chronic Heart Failure

VISTA
Start date: December 2010
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine whether cardiac resynchronization therapy (CRT) is superior to interventricular right ventricle (RV) septal pacing in respect of reverse remodeling (LV ESD) and morbidity in patients with less preserved (less than 45%) ejection fraction (EF), persistent/permanent atrial fibrillation (AF) who successfully received atrioventricular (AV) junction ablation ablation (100% pacemaker dependency)

NCT ID: NCT01483183 Terminated - Atrial Fibrillation Clinical Trials

Ascending Dose Study of OPC-108459 Intravenous Infusions in Patients With Paroxysmal and Persistent Atrial Fibrillation

CADENCE 215
Start date: November 2011
Phase: Phase 1
Study type: Interventional

The purpose of Part 1 of this study is to determine the maximally tolerated dose of OPC-108459 in patients with paroxysmal and persistent atrial fibrillation (AF). The purpose of Part 2 of this study is to determine potential efficacy of dose(s) of OPC-108459 for the treatment of paroxysmal and persistent atrial fibrillation.

NCT ID: NCT01416935 Terminated - Atrial Fibrillation Clinical Trials

Necessity of Anti-Arrhythmic Medication After Surgical Ablation for Atrial Fibrillation

Start date: January 1, 2011
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether anti arrhythmic medication, specifically Amiodarone, is required during the first three months post surgical ablation. Hypothesis: Amiodarone will not be required during the first three months as verified by no increase in rehospitalizations for recurrent Atrial Fibrillation, and report of sinus rhythm at surgical follow up (approximately 3 weeks from date of surgery), 6 weeks and 12 weeks to include patients' first follow up with cardiologist at approximately 3 months post surgery.

NCT ID: NCT01360918 Terminated - Atrial Fibrillation Clinical Trials

Concomitant Epicardial Pulmonary Vein Isolation in Patients With Atrial Fibrillation Undergoing Elective Cardiac Surgery

CONTROL-AF
Start date: May 2011
Phase: N/A
Study type: Interventional

Recent studies demonstrated that radiofrequency isolation of the pulmonary veins (PVI) is a superior alternative to antiarrhythmic drug therapy in patients with symptomatical paroxysmal atrial fibrillation (AF). A substantial proportion of patients undergoing elective cardiac surgery also suffer from atrial fibrillation. No evidence exists if epicardial PVI is beneficial in patients with a history of AF undergoing coronary bypass surgery (CABG) for the concomitant treatment of AF. The investigators aim to establish the effectiveness of incorporating epicardial pulmonary vein isolation into elective cardiac surgery.

NCT ID: NCT01352702 Terminated - Atrial Fibrillation Clinical Trials

Impact of Dabigatran and Phenprocoumon on Clopidogrel Mediated ADP Induced Platelet Aggregation in Patients With Atrial Fibrillation

Dabi-ADP-2
Start date: May 2011
Phase: Phase 4
Study type: Interventional

The aim of this study is to evaluate whether dabigatran reduces clopidogrel mediated ADP induced platelet aggregation measured by MEA as compared to phenprocoumon after a two-week treatment with either agent.

NCT ID: NCT01336075 Terminated - Clinical trials for Paroxysmal Atrial Fibrillation.

Atrial Fibrillation: Ablation or Surgical Treatment II: FAST II

Start date: April 2011
Phase: N/A
Study type: Interventional

The purpose of this study is to compare two invasive treatments of symptomatic paroxysmal atrial fibrillation: Percutaneous radiofrequency catheter ablation and mini invasive thoracoscopic radiofrequency ablation in patients referred for a first time invasive treatment for atrial fibrillation. The hypothesis is, that mini invasive thoracoscopic radiofrequency ablation as a first time invasive treatment is more effective compared to a percutaneous catheter based technique in patients with symptomatic paroxysmal atrial fibrillation refractory or intolerant to at least one antiarrhythmic drug.

NCT ID: NCT01319747 Terminated - Atrial Fibrillation Clinical Trials

Video-Assisted Thoracoscopic Pulmonary Vein Isolation Versus Percutaneous Catheter Ablation in Atrial Fibrillation Trial

VATCAT
Start date: September 2010
Phase: N/A
Study type: Interventional

Recent studies demonstrated that radiofrequency isolation of the pulmonary veins (PVI) and surgically video assisted thorascopic pulmonary vein isolation (VATS-PVI) are acceptable or even superior alternatives to antiarrhythmic drug therapy in patients with symptomatically paroxysmal atrial fibrillation (AF). However, data comparing effectiveness in both interventions are limited. The investigators want to compare the effectiveness of PVI and VATS-PVI. Secondary objectives are to compare the duration of hospitalization, quality of Life, cost and to compare the satisfaction of the patients.

NCT ID: NCT01276093 Terminated - Atrial Fibrillation Clinical Trials

Pulmonary Vein Ablation Versus Amiodarone in the Elderly

PAVANE
Start date: July 2011
Phase: N/A
Study type: Interventional

The purpose of the study is to demonstrate that in patients of 70 years or older with symptomatic paroxysmal atrial fibrillation (AF) pulmonary vein isolation (PVI) using RF ablation therapy is superior to medical treatment with amiodarone to prevent recurrence of AF.

NCT ID: NCT01259622 Terminated - Atrial Fibrillation Clinical Trials

Effects of Intravenous K201 on the Restoration of Sinus Rhythm in Subjects With Symptomatic Atrial Fibrillation

TUNDRA-AF
Start date: February 2011
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the effects of a single intravenous infusion of K201 compared to placebo in a dose escalating manner on conversion to sinus rhythm, reduction of subject's symptom score, and safety.