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NCT00497887 Clinical Trial

Genetic- and Biological-Markers of Predisposition to Atherosclerosis: Leipzig-Heart Study

Atherosclerosis Clinical Trial

— LE-Heart  

Official title:
Observational Study for Identification of Genetic- and Biological-Markers of Predisposition to Atherosclerosis: Leipzig-Heart Study (LE-Heart)

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT00497887
Other study ID # 276-2005
Secondary ID
Status Recruiting
Phase N/A
First received July 6, 2007
Last updated October 18, 2010
Start date December 2006

Study information
Verified date January 2010
Source University of Leipzig
Contact Joachim Thiery, MD PhD
Phone +49-341-9722201
Email thiery@medizin.uni-leipzig.de
Is FDA regulated No
Health authority Germany: Ethics Commission
Study type Observational

Clinical Trial Summary

Atherosclerotic cardiovascular disease is the major cause of morbidity and mortality in Western societies. It is a complex genetic disorder with many genes involved and significant gene-environment interactions. The aim of the study is to identify novel genetic- and biological-markers of atherosclerosis. Atherosclerosis is assessed in the coronary arteries using coronary angiography as well as in the carotid artery (intima-media-thickness) and peripheral vessels (ankle brachial index). Association analysis of genetic and metabolic markers with atherosclerotic burden will be performed to identify novel factors of disposition to atherosclerotic vascular disease.

Recruitment information / eligibility
Status Recruiting
Enrollment 4000
Est. completion date
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 85 Years
Eligibility Inclusion Criteria:

- Patients assigned to coronary angiography

Exclusion Criteria:

- Cancer

- Acute myocardial infarction

- Inability to give informed consent

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
Germany University of Leipzig, Heart Center, Department of Cardiology Leipzig
Germany University of Leipzig, Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics Leipzig

Sponsors (1)
Lead Sponsor Collaborator
University of Leipzig

Country where clinical trial is conducted

Germany, 

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