Atherosclerosis Clinical Trial
— LE-HeartOfficial title:
Observational Study for Identification of Genetic- and Biological-Markers of Predisposition to Atherosclerosis: Leipzig-Heart Study (LE-Heart)
NCT number | NCT00497887 |
Other study ID # | 276-2005 |
Secondary ID | |
Status | Recruiting |
Phase | N/A |
First received | July 6, 2007 |
Last updated | October 18, 2010 |
Start date | December 2006 |
Atherosclerotic cardiovascular disease is the major cause of morbidity and mortality in Western societies. It is a complex genetic disorder with many genes involved and significant gene-environment interactions. The aim of the study is to identify novel genetic- and biological-markers of atherosclerosis. Atherosclerosis is assessed in the coronary arteries using coronary angiography as well as in the carotid artery (intima-media-thickness) and peripheral vessels (ankle brachial index). Association analysis of genetic and metabolic markers with atherosclerotic burden will be performed to identify novel factors of disposition to atherosclerotic vascular disease.
Status | Recruiting |
Enrollment | 4000 |
Est. completion date | |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 85 Years |
Eligibility |
Inclusion Criteria: - Patients assigned to coronary angiography Exclusion Criteria: - Cancer - Acute myocardial infarction - Inability to give informed consent |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Germany | University of Leipzig, Heart Center, Department of Cardiology | Leipzig | |
Germany | University of Leipzig, Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics | Leipzig |
Lead Sponsor | Collaborator |
---|---|
University of Leipzig |
Germany,
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