Implementation of Neuro Lung Protective Ventilation — NEUROVENT  

Stroke Clinical Trial

Official title: Implementation of Neuro Lung Protective Ventilation in Patients With Acute Brain Injury

Status Active, not recruiting

Clinical Trial Summary

Patients who experience lung injury are often placed on a ventilator to help them heal; however, if the ventilator volume settings are too high, it can cause additional lung injury. It is proven that using lower ventilator volume settings improves outcomes. In patients with acute brain injury, it is proven that maintaining a normal partial pressure of carbon dioxide in the arterial blood improves outcomes. Mechanical ventilator settings with higher volumes and higher breathing rates are sometimes required to maintain a normal partial pressure of carbon dioxide. These 2 goals of mechanical ventilation, using lower volumes to prevent additional lung injury but maintaining a normal partial pressure of carbon dioxide, are both important for patients with acute brain injury. The investigators have designed a computerized ventilator protocol in iCentra that matches the current standard of care for mechanical ventilation of patients with acute brain injury by targeting a normal partial pressure of carbon dioxide with the lowest ventilator volume required.

This is a quality improvement study with the purpose of observing and measuring the effects of implementation of a standard of care mechanical ventilation protocol for patients with acute brain injury in the iCentra electronic medical record system at Intermountain Medical Center. We hypothesize that implementation of a standardized neuro lung protective ventilation protocol will be feasible, will achieve a target normal partial pressure of carbon dioxide, will decrease tidal volumes toward the target 6 mL/kg predicted body weight, and will improve outcomes.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Acute Brain Injury
• Anoxic Brain Injury
• Brain Edema
• Brain Injuries
• Brain Injuries, Traumatic
• Cerebral Edema
• Cerebral Hemorrhage
• Hemorrhage
• Intracerebral Hemorrhage
• Stroke
• Traumatic Brain Injury
• Wounds and Injuries

• NCT number: NCT03243539
• Study type: Interventional
• Source: Intermountain Health Care, Inc.
• Status: Active, not recruiting
• Phase: N/A
• Start date: August 31, 2017
• Completion date: December 31, 2024