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Anesthesia, Local clinical trials

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NCT ID: NCT05951764 Recruiting - Anesthesia Clinical Trials

Prediction Models for Cardiovascular and Neurocognitive Disease Risk in the General Population

CME
Start date: May 2024
Phase:
Study type: Observational

More accurate and earlier identification of people at risk of cardiovascular disease (CVD) and neurodegenerative diseases (memory, cognition, dementia) through the appropriate use of biomarkers could lead to earlier initiation of preventive therapies and potentially avoid sometimes fatal events and complications. Biomarkers are useful for determining the risk of disease, but also for establishing a diagnosis. High inter-individual variability hinders the establishment of general laws that can be- used in predictive medicine. In addition to the lack of validation, other limitations are the low participation rate in screening campaigns (regardless of disease) and the relative difficulty, accuracy, cost and time taken to perform the measurements. The perioperative period is a very good time to screen for cardiovascular and neurodegenerative pathologies for several reasons: - Patients come to their anesthesia consultation and to the operating room because they have a direct visible benefit. - the physiological data collected intraoperatively during systematic monitoring are very "rich" and of very good quality because they are not very noisy - The induction of general anesthesia or the onset of locoregional anesthesia and its maintenance represents a strong and reproducible physiological "test" for the cardiovascular and cerebral systems. - The patients are regularly re-examined postoperatively for the follow-up of their pathology and the possible complications are recorded in their file, allowing a short and medium term follow-up. The project aims to validate a biomarker predictive of cardiovascular complications, the pulse wave velocity, and a biomarker predictive of cognitive disorders, the power of the Alpha wave on the electroencephalogram, from the data usually collected during each anesthesia and during the perioperative period. The objective is to build a predictive model of cardiovascular and neurodegenerative risks, possibly combined, on a survival analysis.

NCT ID: NCT05934253 Recruiting - Anesthesia, Local Clinical Trials

The Effects of Low Viscosity Chloroprocaine Ophthalmic Gel 3% on the Bactericidal Action of Povidone-Iodine

Start date: July 15, 2023
Phase: Phase 4
Study type: Interventional

To evaluate if Iheezo's (chloroprocaine 3%) gel vehicle acts as a barrier on the ocular surface, potentially blocking the bactericidal action of povidone-iodine.

NCT ID: NCT05932186 Not yet recruiting - Shoulder Pain Clinical Trials

Upper Trunk Block Feasibility by Anesthesia Residents

Start date: July 15, 2023
Phase: Phase 4
Study type: Interventional

The study compares between the success rate of interscalene block and upper trunk block performed by anesthesia trainee for intra and postoperative analgesia during shoulder arthroscopy. The duration of performing the block, guidance intervention by the consultant and block failure will be recorded.

NCT ID: NCT05908851 Not yet recruiting - Anesthesia, Local Clinical Trials

Perioperative Pain Management for Total Shoulder Arthroplasty: A Pilot Non-Inferiority Trial

Start date: November 1, 2023
Phase: N/A
Study type: Interventional

Total shoulder arthroplasty (TSA) is a common and effective treatment for end-stage shoulder pathologies. Over the past 25 years, implant designs have evolved and the indications for joint replacement have expanded significantly to include arthritis, rotator cuff arthropathy, complex shoulder trauma and trauma sequelae. This has resulted in a worldwide increase in rates of shoulder replacement surgery. The concomitant increased treatment burden for health care systems has prompted interest in strategies to improve the effectiveness and efficiency of patient care such as streamlining intraoperative procedures, mitigating complications, and reducing length of stay by providing outpatient surgical care. Outpatient lower extremity arthroplasty is commonplace and provides helpful information that can guide the development of outpatient TSA such as careful patient selection and the use of standardized perioperative pain management protocols. In lower extremity arthroplasty, several authors have described challenges associated with nerve blockade and the advantages of high-volume local infiltration analgesia (LIA) for outpatient arthroplasty. Proponents of outpatient TSA also describe the importance of patient selection, standardized perioperative protocols and implementation of comprehensive perioperative pain management strategies that can include the use of perioperative ultrasound guided interscalene brachial plexus blockade with a "single shot" injection, ultrasound guided interscalene brachial plexus blockade with a temporary indwelling catheter (ISB), LIA near the surgical site, and multimodal postoperative analgesics.

NCT ID: NCT05908305 Not yet recruiting - Anesthesia, Local Clinical Trials

Impact of Tramadol Addiction On Dental Anesthesia Success

Start date: June 10, 2023
Phase: Phase 4
Study type: Interventional

The aim is to investigate and to find a correlation between tramadol addiction misuse among Algerian males and Dental Local Anesthesia success while performing dental care and oral surgeries.

NCT ID: NCT05901415 Recruiting - Anesthesia, Local Clinical Trials

Modified LPB and SPB vs Classical LPB and SPB

Start date: August 14, 2023
Phase: N/A
Study type: Interventional

The timing of surgery for hip fractures is crucial for elderly patients. The mortality rate for elderly patients after hip fracture is high, and anesthetic decisions significantly affect the patient's outcome. Regional anesthesia has been shown to have better outcomes than general anesthesia. We proposed a newly developed modified position for the ultrasound-guided combined anterior lumbar and lateral sacral plexus block technique that offers benefits, including minimizing interference with circulation and anesthesia, avoiding position change and pain, and providing effective postoperative analgesia.

NCT ID: NCT05899296 Completed - Anesthesia, Local Clinical Trials

Assessment of Pain, Anxiety and Efficiency of NumBee Compared to Traditional Local Anesthetic Syringe

Start date: March 15, 2022
Phase: N/A
Study type: Interventional

The study was conducted among a group of dental patients aged (6-8 years old) of both genders to assess the following variables in the needleless interparliamentary anesthesia (NUMBEE) compared to traditional local anesthesia: 1. Pain perception. 2. Pain related behaviors. 3. Dental anxiety 4. Anesthetic efficiency. 5. Patient acceptance and preference

NCT ID: NCT05875519 Active, not recruiting - Diabetes Clinical Trials

Healing Process and Blood Sugar Level Following Local Anesthetic Infiltration With and Without Vasoconstrictor

Start date: May 1, 2023
Phase: N/A
Study type: Interventional

Evaluating the healing of the extraction socket and the glycemic levels before, and after injection of local anesthesia with and without vasoconstrictor in diabetic patients

NCT ID: NCT05875350 Completed - Anesthesia, Local Clinical Trials

Intraligamental Local Anesthesia Versus Infiltration Technique for Extraction of Grade II Mobility Maxillary Molars

Start date: March 1, 2023
Phase: N/A
Study type: Interventional

The study aims to assess the use of intraligamental local anesthetic injection compared to buccal infiltration for extraction of maxillary molars suffering grade II mobility in terms of pain control and extraction duration.

NCT ID: NCT05868642 Completed - Anesthesia, Local Clinical Trials

Impatto Emodinamico Dell'Anestesia Subaracnoidea Titrata Versus Tecnica Single-shot Nei Pazienti Sottoposti ad Artroprotesi d'Anca. RCT

NINO
Start date: June 25, 2018
Phase: N/A
Study type: Interventional

Studying the hemodynamic effects of titrated subarachnoid anesthesia versus conventional single-shot subarachnoid anesthesia