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Analgesia clinical trials

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NCT ID: NCT06238830 Not yet recruiting - Pain, Postoperative Clinical Trials

Evaluation of Multimodal Analgesia With NOL

Start date: February 1, 2024
Phase:
Study type: Observational [Patient Registry]

The study will include 80 patients undergoing Laparoscopic Cholecystectomy Surgery as part of elective requirements. The study is a single-center, prospective, randomized controlled trial The aim of the study is 1. To investigate the effectiveness of multimodal analgesia, which includes the newly introduced external oblique intercostal plane block, with the assistance of NOL (Nociception Level), in the management of postoperative pain following commonly performed Laparoscopic Cholecystectomy surgeries. 2. This approach is intended to objectively assess changes in postoperative recovery scores Patients will be divided into two groups: the Multimodal Analgesia group (Group M), where Erector Obliq Interfascial Plane (EOIP) block, NSAID, and magnesium infusion will be administered, and the control group (Group K).

NCT ID: NCT06231355 Recruiting - Analgesia Clinical Trials

Liposomal vs. Conventional Bupivacaine for Pain Control

Start date: February 21, 2024
Phase: Phase 4
Study type: Interventional

The goal of this pilot study is to test the hypothesis that liposomal bupivacaine extends the duration of paravertebral block in patients undergoing radical nephrectomy, achieving improved analgesia compared to conventional bupivacaine. The main questions it aims to answer are: - Area under curve of numeric rating scale of pain from 12 to 72 h after surgery. - Cumulative opioid consumption during the period of 12 to 72 h after surgery.

NCT ID: NCT06230575 Recruiting - Analgesia Clinical Trials

Locoregional Blocks for Breast Cancer Surgeries

Start date: February 1, 2024
Phase: N/A
Study type: Interventional

Breast surgeries are common operative procedures that require appropriate postoperative analgesia.

NCT ID: NCT06225895 Recruiting - Analgesia Clinical Trials

Bilateral Rhomboid Intercostal Block for Perioperative Analgesia in Patients Undergoing Bilateral Reduction Mammoplasty

Start date: February 1, 2024
Phase: N/A
Study type: Interventional

Bilateral reduction mammoplasty is one of the most commonly performed breast surgery. The Postoperative pain following it should be minimized. Opioid administration for acute pain after reduction mammoplasty surgery has many side effects. Regional block techniques such as paravertebral block and thoracic epidural anesthesia have possible complications and technical difficulties. The new alternative regional techniques such as erector spinae plane block and rhomboid intercostal plane block are clinical trials for providing a safe, easy, and painless anesthetic procedure with adequate postoperative analgesia for a large section of patients undergoing thoracic surgeries.

NCT ID: NCT06224179 Not yet recruiting - Analgesia Clinical Trials

Role of Ultrasound Guided Transversus Abdominis Plane Block in Pain Control After Hepatectomy

U/STAP
Start date: February 1, 2024
Phase: N/A
Study type: Interventional

Inadequately managed acute pain following abdominal surgery originates from somatic pain signals in the abdominal wall and is linked to various unfavorable postoperative outcomes. These consequences encompass patient distress, respiratory complications, delirium, myocardial ischemia, extended hospital stays, an elevated risk of chronic pain, heightened analgesic consumption, delayed bowel function, and an increased need for rescue analgesics. This study aims to assess the postoperative analgesic efficacy of ultrasound-guided Transversus Abdominis Plane (TAP) block using oblique subcostal and posterior approaches in hepatectomy.

NCT ID: NCT06221332 Recruiting - Analgesia Clinical Trials

Sacral Erector Spinae Plane Block in Normal Birth

Start date: January 24, 2024
Phase: N/A
Study type: Interventional

Pregnant women feel severe pain during normal birth and in the postpartum period. Preventing pain during and after birth is very important for both the mother and the baby. Rapid recovery in the postoperative period in pregnant women is very important for both mother and baby. To evaluate this recovery, the quality of recovery-10 scores developed by Shalev et al. are used in pregnant women. Our study will be the first in the literature to use sacral erectör spinae plane block (S-ESPB) in normal birth. Our primary aim in this study is to evaluate the effects of S-ESPB on the quality of recovery and recovery at the 24th hour in pregnant women who will undergo vaginal birth with epidural analgesia, using the Quality of Recovery-10T scores.

NCT ID: NCT06219928 Not yet recruiting - Inflammation Clinical Trials

Comparison of the Effects of Dexmedetomidine and Ketamine Infusion on the Inflammatory Response in Liver Resection

Start date: January 2024
Phase: N/A
Study type: Interventional

Resection is being performed with increasing frequency in the treatment of surgical diseases of the liver. Ischemia-reperfusion injury is a major cause of liver injury occurring during surgical procedures, including hepatic resection and liver transplantation. Dexmedetomidine and ketamine, which are frequently used in anesthesia practice, also have strong anti-inflammatory capacity. The primary aim of this study is to investigate the effect of iv low-dose ketamine and dexmedetomidine infusion on inflammation in liver resection surgery, and the secondary aim is to determine its effect on pain scores.

NCT ID: NCT06213454 Recruiting - Surgery Clinical Trials

Transversus Abdominis Plane Block Compared to Local Anesthetic Wound Infiltration in Gynecologic Oncology Surgery

Start date: March 26, 2024
Phase: Phase 4
Study type: Interventional

This study is being done to see if preoperative transversus abdominis plane (TAP) analgesia will provide similar postoperative pain control, hospital length of stay, and postoperative outcomes compared to surgeon-initiated wound infiltration with local anesthetic in participants undergoing laparotomy for gynecologic indications.

NCT ID: NCT06205875 Recruiting - Surgery Clinical Trials

High Versus Low Dose Serratus Anterior Plane Block After Minimally Invasive Valve Surgery.

Start date: February 21, 2024
Phase: N/A
Study type: Interventional

This study aims to compare the efficacy and quality of pain relief provided by the high-dose serratus anterior plane (SAP) block with the standard SAP block in preventing and treating acute postoperative pain after total endoscopic aortic or mitral valve surgery.

NCT ID: NCT06202664 Recruiting - Analgesia Clinical Trials

Opioid Free Anesthesia for Laparoscopic Cholecystectomy

Start date: January 15, 2024
Phase: Phase 4
Study type: Interventional

The goal of this interventional study is to check the efficacy of Erector Spinae block as Opioid Free Anesthesia for Laparoscopic Cholecystectomy. Laparoscopic Cholecystectomy is a commonly performed day care procedure. Being a day care procedure the anesthetic technique employed should provide adequate analgesia, allow early mobilization of patient and should mitigate nausea and vomiting which occurs quite frequently in this surgical population. If these goals are achieved patients can be discharged early from hospital setting and this leads to overall cost benefits.