Evaluations of the Effects of Tranexamic Acid and Chlorhexidine Gel on Alveolar Osteitis Incidence

Alveolar Osteitis Clinical Trial

Official title:

Evaluation of the Effects of Tranexamic Acid and Chlorhexidine Gel on Alveolar Osteitis Incidence

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT06435832
• Other study ID #: RTEUni
• Status: Active, not recruiting
• Phase: N/A
• Start date: May 16, 2024
• Est. completion date: June 1, 2024

Study information

• Verified date: May 2024
• Source: Recep Tayyip Erdogan University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This intervention is the treatment of alveolar osteitis (alveolitis) with different effects, which occurs due to the formation of clot after extraction, which is one of the most common intervals after tooth extraction.98 healthy patients with molar and premolar teeth with indication for extraction were taken to the Recep Tayyip Erdoğan University Faculty of Dentistry, Department of Oral and Maxillofacial Diseases and Surgery clinic between May 2024 and June 2024 (age: 38 sessions: 19). -62) 113 teeth (85 molar, 28 premolar teeth) were treated with Spongostan placed in the tooth socket after extraction, spongostan with Chlorhexidine gel and spongostan with tranexamic acid, randomly distributed. After extraction, alveolitis was observed and evaluated prospectively using spongostan, chlorhexidine gel and tranexamic acid in the dental sockets. The researcher checked the participants on the 3rd and 7th days after the tooth extraction. The researcher recorded the pain and edema levels by asking the participants between 0 and 10 using the Visual Analogue Scale (VAS). The researcher filled in the forms for the presence of halitosis, trismus and exposed bone socket on the 3rd and 7th days (YES-NO). Permanent analyzes of the study were created with the SPSS package program.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 98
• Est. completion date: June 1, 2024
• Est. primary completion date: May 26, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

1. Healthy individuals between the ages of 18-65

2. Molar and premolar teeth with extraction indication

Exclusion Criteria:

1. Against drugs or substances to be used in surgery (articaine, tranexamic acid, chlorhexidine) have allergies,

2. Those who used antibiotics 30 days before the dental extraction,

3. Clinical and radiological examinations in the operation area 30 days before dental extraction and/or on the day of the procedure.

Any signs of pathology and infection (such as periapical pathology, pericoronitis),

4. Those who routinely use oral antiseptics,

5. Systemic fever, absence of growth such as lymphadenopathy (LAP),

6. Women are lactating or pregnant,

7. Using oral contraceptives,

8. Procedures that were not attended to control appointments (day 3-7) were not included.

Related Conditions & MeSH terms

• Alveolar Osteitis
• Dry Socket
• Osteitis

Intervention

Drug:
• Absorbable Gelatin
After tooth extraction, only saline irrigation was applied and a absorbable gelatin sponge was placed in the socket.
• Chlorhexidine
After tooth extraction, after irrigation with saline, 2% chlorhexidine gel was absorbed into gelatin sponges and placed into the socket.
• Tranexamic acid
Tranexamic acid 50mg/ml for injection after saline irrigation after tooth extraction solution into gelatin sponges was applied to the socket after it was cured.

Locations

Country	Name	City	State
Turkey	Recep Tayyip Erdogan University	Rize

Sponsors (1)

Lead Sponsor	Collaborator
Recep Tayyip Erdogan University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	pain	scored on visual analog scale from 0 to 10	3.-7. days
Primary	edema	scored on visual analog scale from 0 to 10	3. day - 7. day
Primary	trismus	marked yes or no based on clinical examination	3. day - 7. day
Primary	halitosis	marked yes or no based on clinical examination	3. day - 7. day
Primary	alveolar osteitis	marked yes or no based on clinical examination	3. day - 7. day
Primary	smoking habit	marked yes or no based on anamnesis	operated day
Primary	age	marked yes or no based on anamnesis	operated day
Primary	tooth type	marked yes or no based on clinical examination	operated day