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Clinical Trial Summary

Alveolar osteitis (AO; syn. dry socket) is one of the most frequent complications following tooth removal and it is defined as presence of severe postoperative pain in and around the extraction site, which increases in severity at any time between one and three days after extraction, accompanied by a partially or completely disintegrated blood cloth within the alveolar socket, with or without halitosis, and at the same time excluding any other cause for the pain (Blum 2002). To enhance standard treatment of AO, which consists of curettage of the dry socket, rinsing with saline solution, and inducing bleeding from the exposed alveolar bone walls, numerous products have been tested. One of them is hyaluronic acid (HY). The aim of the present study is to investigate the potential effect of HY gel application in the treatment of AO. Specifically, the application of HY only (HY test group; n = 20) or the combination of HY and an absorbable collagen sponge (HY+C test group; n = 20) will be compared to standard treatment (blood clot; control group, n=20). Clinical and patient related outcome parameters will be recorded for up to 14 days after treatment. A more stable blood clot and thus improved wound healing with faster pain reduction is expected through the use of HY.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04853589
Study type Interventional
Source Medical University of Vienna
Contact Danijel Domic, DMD
Phone +4369917230592
Email [email protected]
Status Not yet recruiting
Phase N/A
Start date May 1, 2021
Completion date May 1, 2022

See also
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Completed NCT02382809 - Efficacy of 0.2 % Digluconate Chlorhexidine Mouthwash for Preventing Alveolar Osteitis After Third Molar Extraction Phase 4
Completed NCT00118820 - Antibiotic Efficacy in Third Molar Surgery Phase 3
Completed NCT04151147 - Effect of CGF on Frequency of Alveolar Osteitis Following Partially Erupted Mandibular Third Molar Surgery N/A
Enrolling by invitation NCT04476121 - Use of PRF in Treatment of Dry Socket. N/A
Active, not recruiting NCT04507009 - Clinical Investigation of the Efficacy of CGF and Ozone in the Treatment of Alveolar Osteitis N/A