Clinical Trials Logo

Clinical Trial Summary

The aim of this prospective study was to assess the effectiveness of concentrated growth factors (CGFs) in preventing the development of alveolar osteitis (AO) after the extraction of partially-erupted mandibular third molars.

This study was designed as a randomized controlled clinical trial. In each case, one socket received CGFs and the other served as a control. The predictor variable was the CGFs application and the sides were categorized as 'CGFs' and 'non-CGFs'. The outcome variable was the development of AO during the first postoperative week. Also, demographic variable included age and gender was noted.

Clinical Trial Description

The investigators designed and implemented a randomized single-blind clinical trial.Randomization was performed by simple coin toss to select the side of CGFs fibrin gel placement before the commencement of third molar surgery. In this way, the sides in each patient were randomly divided into 2 study groups:

Group I (test) - with CGFs placed in the extraction socket Group II (control) - without CGFs placement All operations were performed under local anesthesia by the same surgeon. An envelope flap was raised to provide access. Bone removal was done with the help of stainless steel burs. Constant irrigation with saline was used while removing bone to prevent thermal necrosis. Third molar was luxated with the help of straight elevator and then extracted with the help of third molar forceps. After extraction, any remains of the dental follicle were removed and the extraction sockets were irrigated with 60 mL of sterile saline. To prevent the flap laceration, bone contouring was also performed under sterile saline irrigation. CGFs fibrin gel was then randomly placed into one socket and the opposite side was considered as the control. Finally, wound closure was completed with silk suture.

The primary outcome variable was AO, classified as present or absent.It is characterized by postoperative pain in and around the extraction side, which increases in severity within first week after the extraction, accompanied by a partially or totally disintegrated blood clot within the alveolar socket, with or without halitosis. Other defining symptoms that have been reported in the literature are radiating pain towards the temporal region and ear, inflamed gingival margin, ipsilateral regional lymphadenopathy and, less commonly, low-grade fever. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT04151147
Study type Interventional
Source Ege University
Status Completed
Phase N/A
Start date January 2, 2018
Completion date July 30, 2018

See also
  Status Clinical Trial Phase
Completed NCT04091399 - First-in-man Study of Adult Patients Suffered From Alveolar Osteitis Treated Using Stomatological Tamponade Contipro Phase 2
Completed NCT03641482 - NBF Gingival Gel Application After Impacted Lower Third Molar Surgery N/A
Not yet recruiting NCT04853589 - Effect of Hyaluronic Acid on the Therapy of Alveolar Osteitis N/A
Completed NCT02382809 - Efficacy of 0.2 % Digluconate Chlorhexidine Mouthwash for Preventing Alveolar Osteitis After Third Molar Extraction Phase 4
Completed NCT00118820 - Antibiotic Efficacy in Third Molar Surgery Phase 3
Enrolling by invitation NCT04476121 - Use of PRF in Treatment of Dry Socket. N/A
Active, not recruiting NCT04507009 - Clinical Investigation of the Efficacy of CGF and Ozone in the Treatment of Alveolar Osteitis N/A