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Clinical Trial Summary

Background: Alveolar osteitis is one of the most frequent complications after lower third molar extraction, and is usually accompanied by inflammation, pain and poor wound healing. Several local interventions have been used to reduce these complications with limited effectiveness.

Purpose: To clinically evaluate the use of propolis extract, nanovitamin C and nanovitamin E gel for the prevention of surgical complications related to impacted lower third molar extraction.

Methods: A randomized, triple-blind, split-mouth, pilot study is being performed in patients needing bilateral lower third molar extraction with similar surgical difficulty. Surgical extractions are randomly being performed and NBF gingival gel (TG) or placebo (PBG) are randomly being applied inside postextraction sockets by a blinded surgeon. The patients are being instructed to apply it 3 times/day in the surgical wound for 7 days. One month later, the contralateral wisdom tooth is being extracted and the opposite gel is being applied. Alveolar osteitis (AO) is being diagnosed following Blum's criteria. Swelling is being assessed by measuring the facial perimeter. Wound healing is being evaluated with a semi-quantitative scale as good, satisfactory or insufficient. Postoperative pain is being recorded using a visual analog scale (VAS) for 7 days. Analgesic pill intake is being recorded by each patient. Variables are being registered by a blinded researcher to 3M extractions at one, two, three and seven postoperative days.


Clinical Trial Description

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Study Design


Related Conditions & MeSH terms


NCT number NCT03641482
Study type Interventional
Source Universidad Complutense de Madrid
Contact
Status Completed
Phase N/A
Start date September 1, 2016
Completion date February 20, 2018

See also
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Completed NCT00118820 - Antibiotic Efficacy in Third Molar Surgery Phase 3
Completed NCT04151147 - Effect of CGF on Frequency of Alveolar Osteitis Following Partially Erupted Mandibular Third Molar Surgery N/A
Enrolling by invitation NCT04476121 - Use of PRF in Treatment of Dry Socket. N/A
Active, not recruiting NCT04507009 - Clinical Investigation of the Efficacy of CGF and Ozone in the Treatment of Alveolar Osteitis N/A