Aging Clinical Trial
Official title:
Life After Sport: Prior Injury and Sedentary Behavior as Mechanisms of Later Poor Health
Competitive sport increases risk for musculoskeletal injury (e.g., traumatic knee injury) and may position former athletes for early onset of chronic diseases, chronic pain, poor health-related quality of life, and disability. Quantifying function in former athletes with and without a prior injury and non-athlete controls is critical to understanding long-term health trajectories in athletes and informing potential interventional studies. One modifiable factor that may be associated with long-term health in athletes is physical activity patterns. The purpose of this study is to evaluate strength, function, physical activity, dietary patterns, and cardiometabolic health among current and former competitive athletes and in nonathlete controls to evaluate the impact of prior knee injury and sedentary behavior as two potential determinants of later poor health and reduced function.
Status | Recruiting |
Enrollment | 450 |
Est. completion date | August 2027 |
Est. primary completion date | August 2026 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 64 Years |
Eligibility | Please see cohorts for specific inclusion/exclusion criteria Inclusion Criteria: - Age 18-25 years OR age 40-64 years - Current or former collegiate varsity athlete OR non-athlete control Exclusion Criteria: - Neurologic (e.g., stroke, Parkinson's) and/or degenerative disease that impairs function - Pregnancy - Lower extremity joint replacement (e.g., hip or knee replacement) |
Country | Name | City | State |
---|---|---|---|
United States | Marquette University | Milwaukee | Wisconsin |
Lead Sponsor | Collaborator |
---|---|
Marquette University | National Institutes of Health (NIH) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | 30-Second Chair Stand Test (primary outcome for Aim 1) | Physical function (functional performance) will be evaluated using the 30-Second Chair Stand Test, 6-Minute Walk Test, and Stair Climb Test. The 30-Second Chair Stand Test uses a standard height chair and requires the participant to stand up and sit down as many times as possible in 30 seconds. More completions indicate better physical function. | Baseline | |
Primary | Sedentary Behavior (primary outcome for Aim 2) | Physical activity will be monitored continuously using an accelerometer worn for 2 weeks. Physical activity will be classified throughout the day as sedentary, light, moderate, or vigorous using established algorithms. The primary outcome for aim 2 is the mean percentage of waking hours in sedentary behavior. | Baseline | |
Secondary | Strength | Isometric quadriceps and hamstring strength will be assessed using a standardized strength testing machine (i.e., electromechanical dynamometer). | Baseline | |
Secondary | Body Composition | Body composition (i.e., percent body fat) will be assessed via dual-energy x-ray absorptiometry (DXA). | Baseline | |
Secondary | Step Counts | Average daily step counts will also be recorded using an objective physical activity monitor. | Baseline | |
Secondary | Cardiovascular Disease Risk | The American College of Cardiology/American Heart Association Atherosclerotic Cardiovascular Disease Risk Estimator will be used in the midlife participants to estimate 10-year cardiovascular disease risk. | Baseline | |
Secondary | 6-Minute Walk Test | The 6-Minute Walk Test evaluates the distance participants can walk in 6 minutes and is a widely used indicator of function and aerobic capacity. The 6-minute walk test will be evaluated in the midlife participants only. | Baseline | |
Secondary | Stair Climb Test | The Stair Climb Test assesses the time it takes the participant to ascend and descend a flight of stairs. Faster times on the Stair Climb Test are associated with better strength and function. The Stair Climb Test will be evaluated in the midlife participants only. | Baseline | |
Secondary | Sedentary Behavior (follow-up) | Physical activity will be monitored continuously using an accelerometer worn for 2 weeks. Physical activity will be classified throughout the day as sedentary, light, moderate, or vigorous using established algorithms. Mean percentage of waking hours in sedentary behavior and each physical activity classification will be assessed. | Follow-up (an average of 1 year post-baseline) | |
Secondary | 30-Second Chair Stand Test (follow-up) | The 30-Second Chair Stand Test uses a standard height chair and requires the participant to stand up and sit down as many times as possible in 30 seconds. More completions indicate better physical function. | Follow-up (an average of 1 year post-baseline) | |
Secondary | Strength (follow-up) | Isometric quadriceps and hamstring strength will be assessed using a standardized strength testing machine (i.e., electromechanical dynamometer). | Follow-up (an average of 1 year post-baseline) | |
Secondary | Body Composition (follow-up) | Body composition (i.e., percent body fat) will be assessed via dual-energy x-ray absorptiometry (DXA). | Follow-up (an average of 1 year post-baseline) | |
Secondary | Step Counts (Follow-up) | Average daily step counts will also be recorded using an objective physical activity monitor. | Follow-up (an average of 1 year post-baseline) | |
Secondary | 6-Minute Walk Test (follow-up) | The 6-Minute Walk Test evaluates the distance participants can walk in 6 minutes and is a widely used indicator of function and aerobic capacity. The 6-minute walk test will be evaluated in the midlife participants only. | Follow-up (an average of 1 year post-baseline) | |
Secondary | Stair Climb Test (follow-up) | The Stair Climb Test assesses the time it takes the participant to ascend and descend a flight of stairs. Faster times on the Stair Climb Test are associated with better strength and function. The Stair Climb Test will be evaluated in the midlife participants only. | Follow-up (an average of 1 year post-baseline) |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05433233 -
Effects of Lifestyle Walking on Blood Pressure in Older Adults With Hypertension
|
N/A | |
Recruiting |
NCT06032065 -
Sequential Multiple Assessment Randomized Trial of Exercise for PAD: SMART Exercise for PAD (SMART PAD)
|
Phase 3 | |
Completed |
NCT05293730 -
Trial of the Impact of the Electronic Frailty Integrated With Social Needs
|
N/A | |
Recruiting |
NCT03932162 -
Gene Expression Changes In Young and Geriatric Skin
|
Early Phase 1 | |
Completed |
NCT04064528 -
Effects of Age on Amino Acid Delivery to Tendon
|
N/A | |
Completed |
NCT03366129 -
Blood-Brain Barrier Disruption in People With White Matter Hyperintensities Who Have Had a Stroke
|
||
Completed |
NCT06029920 -
Influence of Overground Walking on Biomarkers, Cognitive Function, and Quality of Life in Elderly With Mild Cognitive Impairment
|
N/A | |
Recruiting |
NCT05543980 -
Leg Heat Therapy in Elderly Individuals
|
Phase 2 | |
Recruiting |
NCT05566938 -
Study to Design a Precision Nutrition Strategy at a Group Level in the Elderly
|
N/A | |
Completed |
NCT04894929 -
Comprehensive Geriatric Assessment in the Monitoring of Functional Improvement
|
N/A | |
Not yet recruiting |
NCT06071130 -
Emotion, Aging, and Decision Making
|
N/A | |
Enrolling by invitation |
NCT04641663 -
Multi-target Dietary Supplement Tolerability in an Aging Population (MTDSST)
|
N/A | |
Completed |
NCT04088006 -
The Evaluation of Efficacy and Safety of Hyaluronic Acid Injection on Skin Moisturization and Elasticity
|
N/A | |
Completed |
NCT03695081 -
Patient Pathway Pharmacist - Optimal Drug-related Care
|
N/A | |
Recruiting |
NCT05424263 -
Acetate and Age-associated Arterial Dysfunction
|
Phase 2 | |
Completed |
NCT05601713 -
Mitigating Heat-induced Physiological Strain and Discomfort in Older Adults Via Lower Limb Immersion and Neck Cooling
|
N/A | |
Completed |
NCT04551339 -
Zinc Versus Multivitamin Micronutrient Supplementation in the Setting of COVID-19
|
N/A | |
Recruiting |
NCT04997577 -
Speech Perception and High Cognitive Demand
|
N/A | |
Completed |
NCT05922475 -
Efficacy of Pre-sleep or Post-exercise Protein During 12 Weeks of Resistance Exercise Training
|
N/A | |
Completed |
NCT04015479 -
Peanut Protein Supplementation to Augment Muscle Growth and Improve Markers of Muscle Quality and Health in Older Adults
|
N/A |