Aging Clinical Trial
— GIBKOPOfficial title:
Holistic Approach for Active and Healthy Aging: Physical and Cognitive Activity, and Nutrition
Verified date | March 2019 |
Source | Science and Research Centre Koper |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Within this project the investigators tested the effectiveness of 2-month of computerized cognitive training (CCT) on CogniFit online platform on 77 older adults, which were randomly divided into intervention and control group. The investigators tested close (battery of cognitive functions) and far transfer (postural and mobility control, EEG, blood samples) of the CCT. Additionally, the investigators were interested into seeing a long-lasting effect, therefore participants were brought back to the laboratory 1 year post CCT.
Status | Completed |
Enrollment | 77 |
Est. completion date | September 30, 2018 |
Est. primary completion date | September 30, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 60 Years to 90 Years |
Eligibility |
Inclusion Criteria: - active and healthy older adults with no major health issues - members of the Center for Daily Activity Koper (Slovenia) - had normal or corrected-to-normal vision; - reported no history of cardiovascular, neurological, or psychiatric conditions Exclusion Criteria: - younger than 60 - smoking; regular alcohol consumption; - acute or chronic skeletal, neuromuscular, metabolic and cardiovascular disease condition; |
Country | Name | City | State |
---|---|---|---|
Slovenia | Center for Daily Activity Koper (Slovenia) | Koper |
Lead Sponsor | Collaborator |
---|---|
Science and Research Centre Koper | Albert Einstein College of Medicine, University of Primorska, Vrije Universiteit Brussel |
Slovenia,
Marusic U, Kavcic V, Giordani B, Gerževic M, Meeusen R, Pišot R. Computerized spatial navigation training during 14 days of bed rest in healthy older adult men: Effect on gait performance. Psychol Aging. 2015 Jun;30(2):334-340. doi: 10.1037/pag0000021. Epub 2015 May 4. — View Citation
Marusic U, Verghese J, Mahoney JR. Cognitive-Based Interventions to Improve Mobility: A Systematic Review and Meta-analysis. J Am Med Dir Assoc. 2018 Jun;19(6):484-491.e3. doi: 10.1016/j.jamda.2018.02.002. Epub 2018 Apr 19. Review. — View Citation
Verghese J, Mahoney J, Ambrose AF, Wang C, Holtzer R. Effect of cognitive remediation on gait in sedentary seniors. J Gerontol A Biol Sci Med Sci. 2010 Dec;65(12):1338-43. doi: 10.1093/gerona/glq127. Epub 2010 Jul 19. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in gait speed | The primary outcome is change in gait speed during single- and dual-task conditions from baseline to post-intervention. | up to 8 weeks | |
Secondary | Executive control (Trail-Making Task Forms A and B) | Secondary outcome is change in executive control, measured with TMT A and B tests | up to 8 weeks | |
Secondary | Sensorimotor integration measured with EEG/ERP methodology | Secondary outcome is change ERP components P1, N1, P2 and P3 (amplitudes and latencies) | up to 8 weeks | |
Secondary | Brain-derived neurotrophic factor (BDNF) extracted from peripheral blood sampling | Secondary outcome is change in plasma BDNF plasma extraction evaluated in pg/mL | up to 8 weeks |
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