Effects of Cognitive Intervention on Cognition, Mobility and Brain Electrocortical Activity

Aging Clinical Trial

— GIBKOP  

Official title:

Holistic Approach for Active and Healthy Aging: Physical and Cognitive Activity, and Nutrition

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03860441
• Other study ID #: GIBKOP2017
• Status: Completed
• Phase: N/A
• Start date: July 1, 2017
• Est. completion date: September 30, 2018

Study information

• Verified date: March 2019
• Source: Science and Research Centre Koper
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Within this project the investigators tested the effectiveness of 2-month of computerized cognitive training (CCT) on CogniFit online platform on 77 older adults, which were randomly divided into intervention and control group. The investigators tested close (battery of cognitive functions) and far transfer (postural and mobility control, EEG, blood samples) of the CCT. Additionally, the investigators were interested into seeing a long-lasting effect, therefore participants were brought back to the laboratory 1 year post CCT.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 77
• Est. completion date: September 30, 2018
• Est. primary completion date: September 30, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 60 Years to 90 Years

Eligibility

Inclusion Criteria:

• active and healthy older adults with no major health issues

• members of the Center for Daily Activity Koper (Slovenia)

• had normal or corrected-to-normal vision;

• reported no history of cardiovascular, neurological, or psychiatric conditions

Exclusion Criteria:

• younger than 60

• smoking; regular alcohol consumption;

• acute or chronic skeletal, neuromuscular, metabolic and cardiovascular disease condition;

Related Conditions & MeSH terms

• Aging
• Cognitive Decline
• Cognitive Dysfunction
• Cognitive Impairment
• Motor Coordination or Function

Intervention

Other:
• Computerized cognitive training
Intervention used CogniFit platform with Personalized brain training sub-option

Locations

Country	Name	City	State
Slovenia	Center for Daily Activity Koper (Slovenia)	Koper

Sponsors (4)

Lead Sponsor	Collaborator
Science and Research Centre Koper	Albert Einstein College of Medicine, University of Primorska, Vrije Universiteit Brussel

Country where clinical trial is conducted

Slovenia, 

References & Publications (3)

Marusic U, Kavcic V, Giordani B, Gerževic M, Meeusen R, Pišot R. Computerized spatial navigation training during 14 days of bed rest in healthy older adult men: Effect on gait performance. Psychol Aging. 2015 Jun;30(2):334-340. doi: 10.1037/pag0000021. Epub 2015 May 4. — View Citation

Marusic U, Verghese J, Mahoney JR. Cognitive-Based Interventions to Improve Mobility: A Systematic Review and Meta-analysis. J Am Med Dir Assoc. 2018 Jun;19(6):484-491.e3. doi: 10.1016/j.jamda.2018.02.002. Epub 2018 Apr 19. Review. — View Citation

Verghese J, Mahoney J, Ambrose AF, Wang C, Holtzer R. Effect of cognitive remediation on gait in sedentary seniors. J Gerontol A Biol Sci Med Sci. 2010 Dec;65(12):1338-43. doi: 10.1093/gerona/glq127. Epub 2010 Jul 19. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in gait speed	The primary outcome is change in gait speed during single- and dual-task conditions from baseline to post-intervention.	up to 8 weeks
Secondary	Executive control (Trail-Making Task Forms A and B)	Secondary outcome is change in executive control, measured with TMT A and B tests	up to 8 weeks
Secondary	Sensorimotor integration measured with EEG/ERP methodology	Secondary outcome is change ERP components P1, N1, P2 and P3 (amplitudes and latencies)	up to 8 weeks
Secondary	Brain-derived neurotrophic factor (BDNF) extracted from peripheral blood sampling	Secondary outcome is change in plasma BDNF plasma extraction evaluated in pg/mL	up to 8 weeks