Aging Clinical Trial
Official title:
Chronic Metformin Treatment Induces a Dietary Restriction-like State in Overweight Human
The fact that metformin treatment has been associated with reduced risk of cancer and
cardiovascular disease raises the possibility of a beneficial role of metformin for other
age-related diseases. The actions of metformin resemble the effects of calorie restriction
(CR) to some extent, and microarray analyses have shown that metformin induces a gene
expression profile that aligns with that of CR in animal. The aim of the study is to
investigate whether metformin treatment can induce dietary restriction-like state in human.
Sixty overweight subjects will be included in this study, and participants will be divided 3
groups (20 cases in each group)including metformin group (0.85, twice daily), standard diet
group, and CR group. All subjects will be treated 6 months. At the end of this study, blood
samples and muscle samples will be obtained.
Status | Recruiting |
Enrollment | 60 |
Est. completion date | December 2016 |
Est. primary completion date | December 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 60 Years |
Eligibility |
Inclusion Criteria: - Overweight - Male Exclusion Criteria: - Female - Obesity - Using any other drugs - < 18 years old - > 60 years old - Mental disorders - Surgery history for abdomen |
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
China | Zhang Jiajia | Wuhan | Hubei |
Lead Sponsor | Collaborator |
---|---|
Xiang Guang-da |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The differences of gene expression profile among 3 groups. | The gene expression profile will be checked by microarray, and compared the number differences of pathways among 3 groups. | 6 months | Yes |
Secondary | The differences of insulin sensitivity in 3 groups | The insulin sensitivity will be measured by insulin clamp assays, and be compared before and after 6 months as well as among 3 group at the end of this study. | 6 months | Yes |
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