Aging Clinical Trial
Official title:
Chronic Metformin Treatment Induces a Dietary Restriction-like State in Overweight Human
The fact that metformin treatment has been associated with reduced risk of cancer and
cardiovascular disease raises the possibility of a beneficial role of metformin for other
age-related diseases. The actions of metformin resemble the effects of calorie restriction
(CR) to some extent, and microarray analyses have shown that metformin induces a gene
expression profile that aligns with that of CR in animal. The aim of the study is to
investigate whether metformin treatment can induce dietary restriction-like state in human.
Sixty overweight subjects will be included in this study, and participants will be divided 3
groups (20 cases in each group)including metformin group (0.85, twice daily), standard diet
group, and CR group. All subjects will be treated 6 months. At the end of this study, blood
samples and muscle samples will be obtained.
Blood samples will be obtained from all individuals. blood lipids, inflammation markers, insulin, glucose, leptin,adiponectin, ala aminotransferase, asp aminotransferase, creatine phosphokinase,lactate dehydrogenase, alkaline phosphatase,bilirubin, cyclo-oxygenase, citrate synthase, renal function, leukocyte telomere length ratio, and telomerase activity will be measured before and after the treatments.Also, hyperinsulinemic-euglycemic clamp will be performed before and after the treatments. Muscle samples will be obtained by biopsy for 9 individuals (3 cases from each group) at the end of the study. Microarray analysis will be performed for the gene expression profile from the muscle samples. Other protein expressions such asadenosine monophosphate-activated protein kinase (AMPK), peroxisome proliferator-activated receptor coactivator 1a (PGC-1a) activity,will be checked by Western blot. ;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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