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Aging clinical trials

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NCT ID: NCT04314921 Completed - Aging Clinical Trials

10-week Yoga Practice Effect on Cognitive and Motor Function in Older Adults

BDNF
Start date: October 1, 2018
Phase: N/A
Study type: Interventional

Thirty-three healthy elderly people, who were classified into two age groups, participated in this study. All participants had not practiced yoga before and were asked not to perform any sports activities while the research was ongoing. In the experimental group, participants (n = 18) had to participate in 10 weeks of yoga classes. In the control group, participants (n = 15) did not perform any exercises or other changes in their daily living life. Experimental measurements: Brunel, PSS-14 and HAD questionnaires

NCT ID: NCT04295798 Completed - Aging Clinical Trials

Optimizing tDCS to Improve Dual Task Gait and Balance

OptiStim
Start date: February 10, 2020
Phase: N/A
Study type: Interventional

The objective of this study is to determine the acute effects of single sessions of personalized tDCS, traditional tDCS, and sham stimulation on dual task standing and walking in older adults who are free of overt disease yet who present with poor baseline dual task performance.

NCT ID: NCT04284553 Completed - Aging Clinical Trials

Optimizing Electronic Health Record Prompts With Behavioral Economics to Improve Prescribing for Older Adults

NUDGE-EHR
Start date: October 13, 2020
Phase: N/A
Study type: Interventional

Prescribing of potentially unsafe medications for older adults is extremely common; benzodiazepines and sedative hypnotics are, for example, key drug classes frequently implicated in adverse health consequences for vulnerable older adults, such as confusion or sedation, leading to hospitalizations, falls, and fractures. Fortunately, most of these consequences are preventable. Physicians' lack of awareness of alternatives, ambiguous practice guidelines, and perceived pressure from patients or caregivers are among the reasons why these drugs are used more than might be optimal. Reducing inappropriate use of these drugs may be achieved through decision support tools for providers that are embedded in electronic health record (EHR) systems. While EHR strategies are widely used to support the informational needs of providers, these tools have demonstrated only modest effectiveness at improving prescribing. The effectiveness of these tools could be enhanced by leveraging principles of behavioral economics and related sciences.

NCT ID: NCT04278560 Completed - Aging Clinical Trials

Modulating Brain Activity to Improve Goal-directed Physical Activity in Older Adults

Stim-Fit
Start date: February 12, 2020
Phase: N/A
Study type: Interventional

Although the majority of older adults are aware of the compelling evidence that regular exercise is critical to the maintenance of health into old age, most do not meet recommendations for daily exercise. This lack of engagement in 'goal-directed' physical activity stems from numerous interrelated factors including lack of motivation, depressed mood, and cognitive "executive" impairments that diminish one's ability to regulate behavior over time. Intriguingly, each of these factors has been linked to the function of brain networks that include the left dorsolateral prefrontal cortex (dlPFC). Transcranial direct current stimulation (tDCS) is a noninvasive and safe means of modulating the excitability of specific brain regions and their connected neural networks. tDCS designed to facilitate the excitability of the left dlPFC has been shown to improve motivation, mood, and multiple aspects of executive function in healthy adults. The investigators thus hypothesize that tDCS holds promise to increase goal-directed physical activity in older adults. This project aims to conduct a pilot randomized controlled trial on the feasibility and effects of a 2-week, 10-session tDCS intervention targeting the left dlPFC, combined with behavioral intervention aimed at increases daily physical activity, on physical activity over a two-month follow-up period, in relatively sedentary older adults without overt illness or disease.

NCT ID: NCT04276948 Completed - Aging Clinical Trials

Effects of NAD3 Supplementation on Biomarkers of Aging

Start date: June 8, 2020
Phase: N/A
Study type: Interventional

This is a randomized, parallel-group, placebo-controlled, clinical trial in middle-aged and older male and female subjects from Ohio. Subjects will take an over-the-counter dietary supplement or a placebo for 12 weeks. Outcome measures will include body weight, systolic and diastolic blood pressure, standard blood chemistries (e.g. chemistry panel, lipid panel, CBC with differential), changes in mood, vitality, energy, fatigue, productivity, digestive wellness (via anchored Visual Analogue Scales).

NCT ID: NCT04276766 Completed - Aging Clinical Trials

Exploring the Effect of Inorganic Nitrates on the Human Microvascular Physiology - a Pilot Study.

ENIH-MPS
Start date: June 1, 2015
Phase: N/A
Study type: Interventional

We conducted a randomised, placebo-controlled, double blind, cross-over, trial to examine the short-term effect of concentrated beetroot juice on vascular outcomes in a young (18-35 years) and older group (55-75 years). The study included a run-in period of one day preceding the test day. A wash-out period of at least 7 days was implemented to ensure to avoid a carry-over effect of the interventions.

NCT ID: NCT04250870 Completed - Aging Clinical Trials

Physical Fitness in Elderly

Start date: January 5, 2019
Phase: N/A
Study type: Interventional

Aging decreases the physical fitness levels in living beings. The environmental factors also have a major effect on the physical fitness levels. The objective of this study was to compare the physical fitness levels of nursing home residents and community-dwelling elderly people. This study employed 118 participants, who consisted of nursing home residents and community-dwelling elderly people. The physical fitness levels of the elderly people were measured by Senior Fitness Test. The physical fitness levels of the elderly people were measured by Senior Fitness Test. Chair stand test, arm curl test, 2-minute step test, chair sit and reach test, back-scratch test, 8-foot up and go test and body mass index were measured.

NCT ID: NCT04245462 Completed - Aging Clinical Trials

Adequate Protein Intake Per Meal and Physical Disability in Mexican Adults Aged 60 Years and Older

Start date: January 2017
Phase:
Study type: Observational

This study sought to determine if the number of meals per day with an adequate protein content (defined as eating >30 g protein or >0.4 g protein/kg body mass each) is associated with presenting physical disability in Mexican adults aged 60 years and older. Physical disability was evaluated with self-reported questionnaires for different activities of daily living.

NCT ID: NCT04239898 Completed - Healthy Clinical Trials

Microgreen Consumption for Healthy Aging

Start date: July 16, 2019
Phase: N/A
Study type: Interventional

Microgreens are an emerging horticultural food crop with potential to improve human health. Previous research suggests they have broad consumer acceptance and that the micronutrient and bioactive compound levels are higher than that of their mature counterparts. To date, no studies have explored the feasibility of microgreen consumption, gastrointestinal tolerance of microgreen consumption, or their potential health impacts in humans. Therefore, the overall goal of this study is to explore the feasibility and acceptability of daily microgreen consumption, gastrointestinal tolerability, and potential health impacts of red cabbage and red beet microgreens in healthy middle-aged/older men and postmenopausal women - a population inherently at risk for chronic disease, e.g. cardiovascular disease.

NCT ID: NCT04235309 Completed - Aging Clinical Trials

Physical Resilience: Indicators and Mechanisms in the Elderly (PRIME) Collaborative Phase 2

PRIME-Knee
Start date: February 27, 2020
Phase:
Study type: Observational

The purpose of this study is to examine underlying physical resilience (the ability to bounce back) in response to a specific stressor (total knee replacement).