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The Association of Gut Microbes and Their Metabolites With Post-stroke Depression

Acute Ischemic Stroke Clinical Trial

Official title:
Research on the Association of Gut Microbes and Their Metabolites With Post-stroke Depression

Clinical Trial Summary

In this study, the clinical data of patients with AIS were collected, 16s RNA was used to detect the composition and diversity of intestinal flora, and flow cytometry and mass spectrometry were used to detect intestinal flora-related metabolites in plasma，to explore the influence of gut microbiota and its metabolites on stroke prognosis.

Clinical Trial Description

In recent years, more and more studies have been conducted on the gut-brain axis, and gut microbes can affect the brain by regulating immune responses, metabolites, and neurotransmitters. The composition of gut microbiota may affect stroke prognosis, including focal neurological deficits, cognitive impairment, anxiety and depression, and fatigue. In this study, 16s RNA was used to detect the composition and diversity of intestinal flora, and flow cytometry and mass spectrometry were used to detect intestinal flora-related metabolites in plasma. The clinical data of patients were collected, including age, gender, and medical history, NIHSS, mRS, MMSE, Patient Health Questionnaire-9（PHQ9）, Social Support Rating Scale（SSRS）, laboratory and radiology results. The neurological recovery of the patients was assessed after 3 and 6 months, and the presence or absence of post-stroke depression（PSD） and post-stroke fatigue（PSF） was assessed by the Hamilton Depression Scale, the Fatigue Severity Scale（FSS） and the Multidimensional Fatigue Scale（MFS）. To evaluate the relationship between gut microbiota and its metabolites and stroke prognosis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05414227
Study type Observational
Source The Affiliated Hospital of Xuzhou Medical University
Contact Zhang Wei, Master
Phone 15162113531
Email neurodoc0708@126.com
Status Recruiting
Phase
Start date June 6, 2022
Completion date May 31, 2023
View Details
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