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Large Artery Occlusion Treated in Extended Time With Mechanical Thrombectomy Trial — LATE-MT  

Acute Ischemic Stroke Clinical Trial

Official title:
An Investigator Initiated and Conducted, Prospective, Multicenter, Randomized Outcome-blinded Study of Treating Mechanical Thrombectomy Exceeding 24 Hours in Patients With Acute Ischemic Stroke Due to Large Vessel Occlusion

Clinical Trial Summary

A multi-center, prospective, randomized, open-label, adaptive group sequential designed, blinded endpoint assessment (PROBE) clinical trial of endovascular treatment among selected AIS

Clinical Trial Description

The LATE-MT trial aims to determine that compared with standard medical care without MT, performing MT in a time window that exceeds 24 hours after last seen well, is superior on the functional outcome in AIS patients due to LVO who have been carefully selected by clinical and imaging criteria. The secondary aims include comparing with standard medical care without MT, to determine whether performing MT exceeding 24 hours of last known well is safe on the risks of any ICH, sICH, and any SAE. Other secondary aims include early improvement in neurological recovery as measured by NIHSS scores at 7 days; successful recanalization rate; imaging measurements of infarct size at 24-48 hours; death or major disability (mRS 3-6); separately on death and disability (mRS 3-5); HRQoL using Euro-QoL EQ-5D questionnaire; utility-weighted modified Rankin scale scores; duration of hospitalization; residence; and hospital service costs. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05326932
Study type Interventional
Source The George Institute for Global Health, China
Contact Lily Song, PhD
Phone +86 13916466400
Email lsong@georgeinstitute.org.cn
Status Recruiting
Phase N/A
Start date November 3, 2022
Completion date January 30, 2025
View Details
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