Post Acute Cardiac Event Smoking (PACES) Study

Acute Coronary Syndrome Clinical Trial

Official title: Secondary Prevention Following Acute Coronary Syndrome Using Integrated Smoking Cessation and Mood Management

Status Active, not recruiting

Clinical Trial Summary

Summary of the Project :

Quitting smoking following acute coronary syndrome (ACS) can reduce mortality up to 50%. However, depression and smoking are highly co-morbid and depressed mood may interfere with cessation and independently predicts mortality. Thus, a single, integrated treatment for both smoking and depression could be highly effective in reducing post-acute coronary syndrome mortality. Behavioral Activation (BA) is a well established treatment for depression and has recently shown promise as a treatment for smoking cessation. The investigators systematically developed an intervention integrating gold standard smoking cessation counseling with existing BA based mood management techniques for post-ACS smokers; Behavioral Activation Treatment for Cardiac Smokers (BAT-CS).

Objective: For this R01 the investigators will evaluate the efficacy of using a single, integrated treatment that targets both depressed mood and smoking (BAT-CS).

Clinical Trial Description

This project will implement a fully powered efficacy trial enrolling 324 smokers with ACS and randomize them to 12 weeks of either Behavioral Activation Treatment for Cardiac Smokers (BAT-CS) or control condition (including contact match). BAT-CS interventions will focus on smoking cessation and mood management, while the control condition will focus on smoking cessation and general health education. Both groups will be offered the nicotine patch if medically safe. Follow-up assessments will be conducted at end-of-treatment (12 weeks post-discharge for index event), and 6, 9, and 12 months after hospital discharge. The occurrence of major adverse cardiac events and all-cause mortality will be tracked for up to 60 months post discharge. ;

Related Conditions & MeSH terms

• Acute Coronary Syndrome
• Syndrome
• Tobacco Use

• NCT number: NCT03413423
• Study type: Interventional
• Source: Hennepin Healthcare Research Institute
• Status: Active, not recruiting
• Phase: N/A
• Start date: January 29, 2018
• Completion date: May 30, 2026