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Tobacco Use clinical trials

View clinical trials related to Tobacco Use.

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NCT ID: NCT06310187 Not yet recruiting - Oxidative Stress Clinical Trials

Little Cigar Oxidants

Start date: July 2024
Phase: N/A
Study type: Interventional

Determine the effects of little cigars on human exposure to tobacco smoke oxidants. In a balanced randomized cross-over study design in cigarette smokers, subjects will be assigned to 6 exposure groups. These include a high oxidant unflavored little cigar exposure condition, a low oxidant unflavored little cigar exposure condition, a high oxidant flavored exposure condition, a low oxidant flavored exposure little cigar exposure condition, their usual cigarette, and a control condition (unlit little cigar). Following the smoking of each product, exhaled breath condensate samples will be collected at baseline, 30, 60, 90, 120 and 150 minutes. Samples will be analyzed for levels of oxidant markers including hydrogen peroxide, 8-isoprostanes, and C-reactive protein, as well as nicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN).

NCT ID: NCT06303115 Not yet recruiting - Smoking Clinical Trials

CSD231005 Nicotine Pouch Biomarkers of Exposure

Start date: July 15, 2024
Phase: N/A
Study type: Interventional

This will be a multi center open label, randomized, controlled, switching parallel-group study designed to assess changes in select biomarkers of exposure (BoE) in generally healthy smokers following a 5 day in-clinic switch to use of nicotine Pouch investigational products (IPs) compared to continued usual brand (UB) cigarette smoking or smoking abstinence.

NCT ID: NCT06295757 Not yet recruiting - Nicotine Dependence Clinical Trials

Effects of Relighting on Smoke Toxicant Deliveries and Subjective Smoking Measures

Start date: April 1, 2024
Phase: N/A
Study type: Interventional

Characterize effects of relighting on smoke toxicant deliveries and subjective smoking measures. This will be a within-subject comparison in a single experimental group of 30 smokers who report engaging in relighting behaviors. We will assess smoking intensity for relit and non-relit (i.e., smoked continuously without relighting) cigarettes in the natural environment and will conduct in-clinic measurements of smoking topography and subjective responses for relit and non-relit cigarettes. Information on relighting patterns and smoking topography collected from each participant will be used to compare machine-measured smoke yields of key harmful constituents when their usual cigarettes are smoked with and without relighting. Hypothesis: Relit cigarettes will produce higher levels of toxicants than non-relit cigarettes.

NCT ID: NCT06264154 Not yet recruiting - Smoking Clinical Trials

The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers

Start date: April 2024
Phase: N/A
Study type: Interventional

This between-subjects study aims to evaluate the effect of flavor on initial and sustained switching from combustible cigarettes to e-cigarettes among 210 cigarette smokers. After measuring baseline cigarette smoking rate, participants will be randomized to a six-week regimen of fruit-flavored, tobacco-flavored, or menthol-flavored e-cigarettes and be instructed to switch (versus smoking cigarettes) over a 6-week period. Flavor-associated subjective reward and the reinforcing value of flavored e-cigarettes relative to combustible cigarettes will be assessed as mechanisms.

NCT ID: NCT06234722 Not yet recruiting - Tobacco Use Clinical Trials

Modeling Tobacco Regulatory Impacts in Appalachia Using the Experimental Tobacco Marketplace

Start date: March 1, 2024
Phase: N/A
Study type: Interventional

The goal of this project is to look at the effect of proposed tobacco product regulations in Appalachian Kentucky. Appalachian Kentucky is a diverse and underserved rural area that would benefit from more tobacco regulation research. Researchers will study the effects of three proposed tobacco product regulations among users of tobacco products in Appalachian KY. Researchers will also study how degree of rurality effects how those regulations impact behavior. Participants will be asked to complete online surveys and tests, online shopping sessions in a simulated Experimental Tobacco Marketplace, and track their tobacco product use throughout the 9-week experiment.

NCT ID: NCT06179290 Recruiting - Tobacco Use Clinical Trials

Changes in Biomarker of Exposure in Adults Who Smoke Cigarettes Switching From Cigarettes to Heated Tobacco Products

Start date: October 2, 2023
Phase: N/A
Study type: Interventional

The purpose of the study is to evaluate changes in biomarkers of exposure (BoE) to harmful and potentially harmful constituents (HPHCs) in adult smokers who completely switch to Ploom heated tobacco products (HTPs) compared to those who continue to smoke usual brand combustible cigarettes (UBCC).

NCT ID: NCT06171490 Active, not recruiting - Tobacco Use Clinical Trials

Pharmacokinetics and Comparative Bioavailability of Nicotine From Two Variants of NP2, NP2-4mg and NP2-6mg, Compared to Nicotine Lozenge 4mg (Loz-4mg) and Nicotine Gum 4mg (Gum-4mg)

Start date: October 20, 2023
Phase: N/A
Study type: Interventional

This is a multi-center, randomized, controlled, partially blinded study to assess the pharmacokinetics and comparative bioavailability of nicotine from two variants of NP2 (4 and 6 mg) in comparison with Loz-4mg and Gum-4mg in adult cigarette smokers. The subjects will be blinded to the randomized sequence and will be blinded to the variants of NP2 they will receive. The study will be conducted with 4 periods and 4 sequences in a Williams design (crossover).

NCT ID: NCT06105424 Completed - Smoking Clinical Trials

BRP1602: Evaluation of Technical and Logistical Feasibility to Measure Lung Permeability

Start date: September 24, 2016
Phase: N/A
Study type: Interventional

This will be a single-center, single-blind, four-cohort, 22-day ambulatory study during which up to 24 healthy adult subjects [6 smokers (SMK), 6 moist snuff consumers (MSC), 6 vapers (VAP), and 6 non-tobacco consumers (NTC)] will complete 3 measurements of lung permeability. Nasal epithelial cells, sputum, and blood samples will also be collected for current and future biomarker research.

NCT ID: NCT06074939 Not yet recruiting - Tobacco Use Clinical Trials

FRESHAIR4Life: Building the Case for Action

Start date: October 2023
Phase:
Study type: Observational

The goal of this observational study is to understand the burden and determinants of tobacco use and air pollution (AP) exposure among mid- to late adolescents in Greece, the Kyrgyz Republic, Pakistan, Romania, and Uganda. This context-specific knowledge will be crucial for selecting, adapting, and implementing preventive interventions in the next phase of the project. The main questions the investigators aim to answer are: - What is the perceived burden of tobacco use and AP exposure among adolescents? - What are the contextual drivers and behavioral determinants contributing to (prevention of) these risk factors? - How do the dynamics between stakeholders influence prevention efforts? In this study, data will be collected through interviews, focus group discussions, photovoice, document analysis, observations, personal exposure monitoring, and questionnaires.

NCT ID: NCT06042361 Enrolling by invitation - Clinical trials for Tobacco Use Disorder

Enhancing Equity in Smoke-free Housing

Start date: September 1, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to learn about the acceptability, feasibility, and effectiveness of smoke-free housing policy implementation in Permanent Supportive Housing communities. The main objective of this study is to identify and refine adaptations for a smoke-free housing implementation framework that incorporates behavioral health support and meets the needs of residents living in Permanent Supportive Housing.