Clinical Trials Logo

Active Chronic Graft Versus Host Disease clinical trials

View clinical trials related to Active Chronic Graft Versus Host Disease.

Filter by:
  • None
  • Page 1

NCT ID: NCT01001780 Withdrawn - Clinical trials for Active Chronic Graft Versus Host Disease

Pentostatin, Cyclophosphamide Plus Rituximab (PCR) for the Therapy of Poor-Prognosis Chronic Graft-Versus-Host Disease

Start date: August 2009
Phase: Phase 2
Study type: Interventional

Chronic graft-versus-host disease (GvHD) is a severe, life threatening complication from getting a bone marrow or stem cell transplant. It is caused by certain cells from the donor that attack your cells. The usual treatments, prednisone and cyclosporine, don't work very well in chronic GVHD. This research is being done to determine if the combination of the chemotherapeutic and immunosuppressive, drugs pentostatin, cyclophosphamide and the monoclonal antibody rituximab, used as in the "PCR" combination will prove useful in the treatment of certain patients with chronic GvHD (namely those who are unlikely to respond to standard therapy).