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Mouth Diseases clinical trials

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NCT ID: NCT05039320 Active, not recruiting - Oral Disease Clinical Trials

The Effect of Probiotics on Oral Health

Start date: September 2, 2021
Phase: N/A
Study type: Interventional

This will be a double-blind, randomized, placebo-controlled two-arm parallel groups study of the effect of oral probiotics containing Streptococcus salivarius K12 on oral biofilm, salivation rate, and secretory immunoglobulin A salivary level. The aim of the study is to compare the effect of oral probiotics containing Streptococcus salivarius K12 strain on oral biofilm, unstimulated salivary flow rate, and salivary secretory immunoglobulin A (sIgA) levels.

NCT ID: NCT04637919 Not yet recruiting - Clinical trials for Hand, Foot and Mouth Disease

Safety and Immunogenicity of High-dose IN-B001 in Healthy Subjects

Start date: December 2020
Phase: Phase 1
Study type: Interventional

This study aims to evaluate the safety and immunogenicity of high-dose IN-B001 after administration in healthy subjects

NCT ID: NCT04602572 Not yet recruiting - Obesity Clinical Trials

Obesity and Oral Diseases in Adult Patients

ObOd
Start date: December 1, 2021
Phase:
Study type: Observational

Overweight and obesity are among the major chronic disorders of the 21st century and one of the fastest growing health problems worldwide. Obesity is accompanied by a state of low-grade inflammation which may contribute to the occurrence of diabetes mellitus, cardiovascular disease, hypertension, stroke, and certain cancers. Furthermore, obesity has been associated with oral health problems as hyposalivation, dental caries and periodontitis. The management and treatment of obesity is outlined in clinical guidelines from American Association of Clinical Endocrinologists/American College of Endocrinology and European Association for the Study of Obesity. The cornerstone is life-style modification programs aiming to reduce energy intake and increase physical activity, referred to as conservative treatment. All patients must undergo a thorough systematic work-up. The work-up concludes in a final multi-disciplinary meeting with a concrete individualized plan on how sustained weight-loss is to be achieved; either by a non-surgical or a surgical approach (Bariatric surgery). Periodontitis is cited to be the sixth most prevalent chronic condition globally. The mechanisms by which obesity affects the periodontal tissues is poorly understood, and the understanding of the key role of adipocytes in the inflammatory response to infections is crucial in comprehending how periodontal disease susceptibility may be modified in obese individuals. The main objectives of the present research project are to explore the association between obesity and oral diseases and further, to assess how weight changes following non-surgical and surgical interventions of obese patients may affect the cariological and periodontal health status. Four hundred patients referred to the Obesity Centre at Haukeland University Hospital, Norway will consecutively be screened and invited to participate in this prospective cohort study. At baseline, detailed medical and oral data will be obtained from health forms, questionnaires, clinical examinations, and by consulting the patient's care team. Following baseline examination, all patients will undergo a thorough systematic work-up consisting av interviews and consultations concluding in a final multi-disciplinary individualized non-surgical or surgical treatment plan on how sustained weight-loss can be achieved. New sets of medical, oral, and molecular data will be collected at 3-, 12- and 18-month following non-surgical/surgical interventions.

NCT ID: NCT04581486 Not yet recruiting - Malnutrition Clinical Trials

Effectiveness of an Optimal-Massive Intervention in Older Patients With Dysphagia

OMI
Start date: December 2020
Phase: N/A
Study type: Interventional

The aim of this study is to evaluate the efficacy of an optimal-massive intervention (OMI) based on increasing shear viscosity of fluids, nutritional support with oral nutritional supplements (ONS) and triple adaptation of food (rheological and textural, caloric and protein and organoleptic) and oral hygiene improvement on the incidence of respiratory infections in older patients with OD. We have designed a randomized clinical trial, with two parallel arms and 6 months follow-up. The study population will be constituted by older patients of 70 years or more with OD hospitalized at Hospital de Mataró by an acute process that will be identified by using the volume-viscosity swallow clinical test. We will consecutively recruit 500 subjects during admission (Geriatrics, Internal medicine, etc.) at the Hospital de Mataró. Patients included will be randomly assigned to one of both interventional groups: a) study intervention: multifactorial intervention based on fluid viscosity adaptation (with a xanthan gum thickener -> Nutilis Clear®), nutritional support with a triple adaptation of food (texture, caloric and protein content, organoleptic) + pre-thickened ONS and evaluation and treatment of oral hygiene (tooth brushing + antiseptic mouthwashes + professional dental cleaning), or b) control intervention: standard clinical practice (fluid adaptation with Nutilis Powder and simple texture adaptation for solids). Main outcome measures: respiratory infection incidence during the 6-month period follow-up. Secondary outcomes: mortality at 6 months, general hospital readmissions and readmissions due to respiratory infections, nutritional status, hydration status, quality of life, functional status, oral hygiene and dysphagia severity and its relationship with other study variables.

NCT ID: NCT04467541 Completed - Clinical trials for Hand Foot & Mouth Disease

Safety & Immunogenicity of Enterovirus Type 71 Vaccine in Healthy Adults and Children 6-71months

Start date: December 24, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

1. Burden: Hand-foot-and-mouth disease (HFMD) characterized by skin rash in extremities, mouth ulcer and fever among <5 years children.Primarily caused by Enterovirus- predominantly human Enterovirus (EV) 71 and Coxsackie virus (CoxA). Several large epidemics have been reported worldwide.Large Asia-Pacific epidemic-in China in 2008, approximately 490,000 infections and 126 deaths of children. EV71 contributes severe and fatal cases e.g. encephalitis.A recent outbreak of HFMD in Bhubaneswar, Odisha in India indicates there is a chance of HFMD outbreaks in Bangladesh. However there is not much report of HFMD from Bangladesh. 2. Knowledge gap: EV71 is most commonly transmitted via close person-to-person contact. Since there is no known effective treatment for HFMD and as the causative virus is highly contagious, hand washing is the best defense for prevention. However, asymptomatic or mild nature of the infection leads to ineffectiveness of public health interventions like hand washing. Thus the symptomatic management remains the mainstay of treatment strategy for HFMD as of now. EV71 vaccine, an inactivated vaccine, developed by Sinovac Biotech Ltd has shown satisfactory safety and effectiveness through Phase III trials conducted in various regions of mainland China, This new vaccine has the potential to significantly reduce suffering and death from EV71 disease in China. However, it is not assessed on Bangladeshi child. 3. Relevance: Due to the absence of effective public health strategy and proper treatment, the development of an effective vaccine may be the best way to control EV71 infection.

NCT ID: NCT04434014 Recruiting - Diet, Healthy Clinical Trials

Proper Nutrition And Its Relation To Oral Diseases In Covid -19 Era

Start date: June 8, 2020
Phase:
Study type: Observational

effect of proper diet and vitamins on the oral health and the regeneration of the taste and smell in Covid 19 patients

NCT ID: NCT04386421 Recruiting - Oral Disease Clinical Trials

A Comparison of Three Different Modalities in Improving Oral Hygiene

Start date: September 1, 2020
Phase: Phase 4
Study type: Interventional

The objective of the study is to compare effectiveness of OHI modalities a. verbal vs videographic material, b. Verbal vs plaque disclosing tablet and c. Videographic material vs plaque disclosing tablet over 3 months in adult orthodontic patients undergoing Fixed Appliance Treatment (FAT). Secondary objective of this study is to evaluate influence of three different modalities on patient cooperation and compliance towards orthodontic treatment.

NCT ID: NCT04295525 Not yet recruiting - Oral Diseases Clinical Trials

Carnosine Supplementation on Quantity/Quality of Oral Salivae.

PHoral
Start date: March 1, 2020
Phase: N/A
Study type: Interventional

The aim of this study is to elucidate the mutual relationship between salivae characteristics and oral microbiome and to compare them with common oral disease; furthermore, by using specific bioinformatic tools to analyse the data, the potentials of Carnosine in preventing/treating oral diseases and its mechanism of action will be addressed by using quantitative proteomics.

NCT ID: NCT04273386 Recruiting - Systemic Sclerosis Clinical Trials

Mouth Handicap in Systemic Sclerosis

Start date: December 2, 2019
Phase: N/A
Study type: Interventional

In this study, it is aimed to investigate the mouth handicap in Systemic Sclerosis.

NCT ID: NCT04182932 Recruiting - Clinical trials for Hand, Foot and Mouth Disease

Safety and Immunogenicity of CJ-40010 in Healthy Subjects

Start date: December 2, 2019
Phase: Phase 1
Study type: Interventional

This study aims to evaluate the safety and immunogenicity of CJ-40010 after administration in healthy subjects