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Mouth Diseases clinical trials

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NCT ID: NCT05656417 Not yet recruiting - Gingivitis Clinical Trials

Individual Variability of Experimental Gingivitis Response

Start date: December 2022
Study type: Observational

The study aims to investigate the genetic cause of the variability between individuals seen in the development of the gum disease, gingivitis. This will be carried out through a 3 week programme where all oral hygiene is ceased, allowing 'experimental gingivitis' to develop, followed by a period of recovery when tooth cleaning is restored. Clinical assessments and biological samples will be taken during the course of the study for further analysis.

NCT ID: NCT05637229 Active, not recruiting - Clinical trials for Hand, Foot and Mouth Disease

A Serosurvey Study of Hand, Foot, and Mouth Disease in Indonesia

Start date: November 1, 2022
Study type: Observational [Patient Registry]

This study is a sero-survey study of infants aged 6 months to 71 months in Bandung City and West Bandung District. As initial data to find out how many children have been exposed to human enterovirus type 71 (HEV-71) which causes Hand, foot, and mouth disease (HFMD).

NCT ID: NCT05540171 Not yet recruiting - HIV Clinical Trials

An Educational Intervention Program to Improve the Oral Health of HIV-Positive Children in Kano, Nigeria.

Start date: September 26, 2022
Phase: N/A
Study type: Interventional

The aim of this 2- arm randomized-control study is to determine the effect of an oral hygiene self care intervention on the oral health status and oral health-related quality of life (OHRQoL) of HIV-positive children (age: 8-16 years, n=170) presenting to five pediatric HIV clinics in Kano, Nigeria. The intervention will comprise oral health education and instructions on oral self-care. Data on oral health status and OHRQoL will be obtained at baseline and at 1, 3 and 6 months. Study findings will help inform policies to improve the oral health and OHRQoL of HIV-positive Nigerian children and guide the integration of oral health care services into HIV programs.

NCT ID: NCT05439382 Active, not recruiting - Surgery Clinical Trials

Analysis of Root Coverage Stability.

Start date: January 1987
Study type: Observational

One-hundred and one healthy participants (221 gingival recessions-GRs) were treated from 1987 to 1996. The probing depth (PD), keratinized tissue width (KTW), gingival recession depth (RD), gingival recession width (RW), gingival recession area (RA) were evaluated and considered at baseline and along time. The obtained data will be evaluated and compared.

NCT ID: NCT05435131 Completed - Clinical trials for Periodontal Diseases

Evaluation of Biomarkers Levels in Gingival Crevicular Fluid, Saliva and Serum for Different Periodontal Diseases

Start date: June 1, 2020
Phase: N/A
Study type: Interventional

The aim of this study is; detection of interleukin(IL)-38, IL-36 gamma(γ) , IL-17 and matrix metalloproteinase(MMP)-9 levels in gingival crevicular fluid (GCF), saliva and serum samples of periodontally healthy, gingivitis and periodontitis patients and the possible correlation between these values and clinical parameters of periodontal diseases. Materials and methods: Samples were obtained from 90 systemically healthy non-smoker individuals with periodontitis (P, n=30), gingivitis(G, n=30) and healthy periodontium (S, n=30). Full-mouth clinical periodontal measurements including probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), gingival index (GI) and plaque index (PI) were also recorded. Enzyme-linked immunosorbent assay (ELISA) was used to determine IL-38, IL-36γ, IL-17 and MMP-9 levels in the biological samples.

NCT ID: NCT05418335 Completed - Stroke Clinical Trials

Oral Health and Vitamin D in Stroke Patients

Start date: July 12, 2022
Study type: Observational

Stroke is a common, serious and restrictive global health problem. Restricting the activities of daily living of stroke patients impairs patients' ability to pay attention to oral hygiene. Facial paresis and tongue weakness due to stroke may cause a decrease in the control of dental prostheses and the removal of food residues in the oral cavity. Food residues and saliva contaminated with bacteria as a result of poor oral hygiene can result in pneumonia when aspirated due to oropharyngeal dysphagia. In the literature, it has been shown that there are significant relationships between periodontal health and vitamin D and calcium intake, and that dietary supplementation with calcium and vitamin D can improve periodontal health, increase bone mineral density in the mandible, and inhibit alveolar bone resorption. In line with all these data, our hypothesis in this study is to investigate the relationship between oral health and vitamin D levels in stroke patients in rehabilitation units.

NCT ID: NCT05397587 Not yet recruiting - Clinical trials for Hand, Foot and Mouth Disease

An Immunity Persistence Study of Enterovirus 71 Inactivated Vaccine (Vero Cell)

Start date: July 30, 2022
Phase: Phase 4
Study type: Interventional

This is an open,observational and follow-up clinical trial based on the clinical trial of EV71 vaccine extended age group.The purpose of this study is to evaluate the immunity persistence of EV71 vaccine developed by Sinovac Biotech Co., Ltd in subjects aged 6 ~71 months after full immunization of two doses of vaccine.

NCT ID: NCT05390099 Recruiting - Oral Disease Clinical Trials

Anti-Plaque and Anti-Gingivitis Effects of Moringa Plant Extract and Fluoride Toothpastes

Start date: April 1, 2022
Phase: N/A
Study type: Interventional

The present study aims to assess and compare the anti-plaque and anti-gingivitis effects of Moringa plant extract and Fluoride toothpastes among a group of Egyptian Children.

NCT ID: NCT05389124 Recruiting - Gingivitis Clinical Trials

Metagenome Resilience in Experimental Gingivitis

Start date: May 23, 2022
Study type: Observational

This study aims to identify new biomarkers that indicate the resilience of individuals to developing oral disease. An 'experimental gingivitis' model will be employed in which subjects will refrain from oral hygiene in one quadrant of their mouths for 3 weeks, and will then restore oral hygiene. Gum inflammation will be monitored by clinical measures throughout the trial and samples will be collected for analysis of microbial DNA and RNA.

NCT ID: NCT05311410 Recruiting - SARS-CoV2 Infection Clinical Trials

Viral Kinetics of SARS-CoV-2 in Patients With COVID-19 in the Intensive Care Unit Undergoing Dental Procedures

Start date: September 20, 2021
Phase: N/A
Study type: Interventional

The prevalence and clinical relevance of viremia in patients with COVID-19 have not been well investigated. Seeking to understand the need for dentistry to perform bloody procedures in critically ill patients with COVID-19 admitted to the ICU, the quantification of the magnitude of viral replication may play a fundamental role in this scenario. For this, it is necessary to study the viremia kinetics of SARS-CoV-2, seeking to assess whether there is any characteristic pattern that may be associated with a worse clinical outcome of the patient with COVID-19 after undergoing bloody dental procedures, therefore, the objective of this research will be to investigate the occurrence of viral kinetics produced by dental procedures in patients with SARS-CoV-2 in Intensive Care Units, where, in addition to analyzing the oral health condition, the viral kinetics of SARS-CoV-2 will also be investigated by means of reverse transcription polymerase chain reaction (RT-PCR) examination of blood samples from patients with COVID-19 undergoing bloody dental treatment. This research is expected to identify risks and consequences regarding the possibility of performing bloody dental treatment in patients with COVID-19 in serious condition, in addition to verifying the association of the impact of oral infection foci on this profile of patients.