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Mouth Diseases clinical trials

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NCT ID: NCT06457724 Active, not recruiting - Oral Health Clinical Trials

Lactobacillus Brevis Oral Health

Start date: September 1, 2022
Phase: N/A
Study type: Interventional

This RCT investigates the impact of an oral supplement containing the probiotic Lactobacillus brevis CD2 on various salivary indicators of oral health. Participants will be randomly assigned to either the probiotic supplement group or a placebo group. The primary objective is to assess changes in salivary biomarkers, including salivary pH and buffer capacity; microbial composition using microbiome next-generation sequencing (NGS); and clinical oral inflammatory markers, such as full mouth bleeding score and full mouth plaque score, over a 4-week period. By comparing these indicators between the two groups, the study aims to determine the efficacy of Lactobacillus brevis CD2 in promoting oral health and potentially preventing oral diseases.

NCT ID: NCT06455007 Completed - Clinical trials for Propolis Antiviral Activity

Propolis as a Treatment Option for Hand Foot and Mouth Disease

Start date: January 1, 2019
Phase: Phase 2/Phase 3
Study type: Interventional

Hand foot and mouth disease (HFMD) is a frequently self-limited viral infectious disease in children with no specific antiviral treatment option. There has been an increasing interest in bee products in recent years, and propolis has come to the fore with its high therapeutic and protective effect. Although the inhibitory effect of propolis against enteroviruses (EVs) has been shown in studies, there is no clinical data regarding its use in the course of HFMD. The aim of this prospective multicenter randomized clinical study was to evaluate the effect of propolis use in children with HFMD. The patients were randomly assigned to have Anatolian propolis or no supplement - control group in addition to symptomatic therapy decided by the physician. The duration of the patients' complaints, the distribution of the lesions in the body, and the fever status were recorded on admission. Parents were asked to rate the severity of the child's restlessness, inappetence, and sleeplessness status on a scale of 0-10 on the initial, 2nd (at 48th hour), and 3rd (on 5-7 days) visits.

NCT ID: NCT06381700 Not yet recruiting - Oral Disease Clinical Trials

Effectiveness of MySmile App for Improving the Oral Health of Secondary School Children:

Start date: May 2024
Phase: N/A
Study type: Interventional

The goal of this cluster-randomised control trial is to assess the effectiveness of the MySmile app for improving oral health in secondary school children. The main questions it aims to answer are: 1. Will the MySmile app be more effective in improving secondary school children's dental plaque and gingival health over and above the existing school dental service (SDS)? 2. Will the MySmile app be more effective in improving secondary school children's oral health knowledge, attitudes, and behaviours over and above the existing SDS? 3. Is the MySmile app easy to use by secondary school children? 4. Is the MySmile app acceptable to use from the perspective of secondary school children? Participants in the intervention group will receive the SDS and MySmile app. The control group will receive SDS only. Therefore the researcher will compare between the intervention and control group in terms of dental plaque, gingival health, oral health knowledge, oral health attitudes and oral health behaviours.

NCT ID: NCT06381505 Not yet recruiting - Oral Cavity Disease Clinical Trials

RetracTOR/ Retractor for Image Guided Trans-Oral Surgery

Start date: May 15, 2024
Study type: Observational

This study aims to demonstrate that a polymer retractor functions the same as a standard metal retractor used during endoscopy and throat surgery. The retractor is the device that holds the mouth open so the surgeon can easily access the mouth and throat. For example, this study aims to confirm that the mouth is held open the same amount with a polymer retractor as it is with a metal retractor. Benchtop experiments have demonstrated that the metal and polymer retractor's function the same, and thus this study will use this in patients.

NCT ID: NCT06353477 Completed - Clinical trials for Hand, Foot, and Mouth Disease

Hand, Foot, and Mouth Disease: Could EPs®7630 be a Treatment Option

Start date: June 1, 2019
Phase: Phase 2/Phase 3
Study type: Interventional

This randomized controlled study aims to evaluate the effectiveness and safety of the pharmaceutical extract EPs® 7630 from P.sidoides in treating hand, foot, and mouth disease in children. The study will investigate the impact of EPs® 7630 on the severity of the disease over a specific period and its effects on hospitalization rates and potential complications. This research aims to contribute to the treatment of hand, foot, and mouth disease in children.

NCT ID: NCT06341959 Recruiting - Oral Disease Clinical Trials

Can a Low-threshold Check-up Motivate Older People to Schedule a Dental Visit?

Start date: April 25, 2024
Phase: N/A
Study type: Interventional

There is little research on the effect of oral screening campaigns for improving oral health in older people. Therefore, the aim of this study is to investigate the effect of a low-threshold contact with an oral health professional, including an oral health examination, on dental attendance of older people (65 years of age or older).

NCT ID: NCT06332846 Completed - Stroke, Ischemic Clinical Trials

Oral Health in Patients Hospitalized Because of Ischemic Stroke

Start date: October 10, 2019
Study type: Observational

Maintaining good oral health is essential for general health and quality of life. Results of many anal-yses showed that stroke patients had poorer oral condition and worse periodontal status than control population. The aim of the study was to carry out a clinical observation concerning condition of oral health in stroke patients and healthy population. The oral health was assessed in patients with stroke and in (control group). The following elements were assessed: missing teeth, the presence of active caries foci, the presence of existing fillings and prosthetic restorations. To assess oral hygiene API (Approximal Plaque Index) was used. As part of periodontal examina-tion, the following were assessed: the presence of dental deposits, the depth of the existing periodontal pockets, tooth mobility according to Hall and Sulcus Bleeding Index during probing (SBI).

NCT ID: NCT06263439 Recruiting - Clinical trials for Hand, Foot and Mouth Disease

Surveillance of HFMD in Pediatric Outpatients

Start date: June 20, 2023
Study type: Observational

The aims of this prospective multicentric study is to determine the types of enteroviruses (EVs) responsible for hand, foot and mouth disease (HFMD) or herpangina in children seen within an ambulatory setting : - to detect an EV-A71 epidemic or another type associated with atypical forms of the disease at an early stage - to describe and compare the epidemiological, demographic, clinical and virological characteristics of these infections between the different types of EV.

NCT ID: NCT06251219 Not yet recruiting - Clinical trials for Hand, Foot and Mouth Disease

Active Case Finding of Clinical Hand Foot Mouth Disease in Children Aged 6 Months Old to 18 Years Old in Indonesia

Start date: February 1, 2024
Study type: Observational

An observational study of active case surveillance to identify the pathogens of clinically diagnosed HFMD cases aged 6 months to 18 years old recruited from puskesmas and hospitals in Indonesia.

NCT ID: NCT06209398 Active, not recruiting - Clinical trials for Hand, Foot and Mouth Disease

Immunogenicity of the Inactivated EV71 Vaccine Combined With Hepatitis B and Group A Meningococcal Vaccine

Start date: May 24, 2018
Phase: Phase 4
Study type: Interventional

The main purpose of this study is to evaluate the immunogenicity and safety of inactivated enterovirus type 71 vaccine combined with recombinant hepatitis B vaccine or Group a meningococcal polysaccharide vaccine.