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Rheumatic Diseases clinical trials

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NCT ID: NCT04848493 Not yet recruiting - COVID-19 Clinical Trials

National Project on Vaccines, COVID-19 and Frail Patients

VAX4FRAIL
Start date: April 20, 2021
Phase:
Study type: Observational

This is a multicentre observational study with the aim of evaluating the antibody and cellular response after vaccination for SARS-CoV-2 with Pfizer-BioNTech or Moderna vaccines in frail subjects with impaired immuno-competence, due to their underlying diseases or ongoing therapies.

NCT ID: NCT04845997 Not yet recruiting - Rheumatic Diseases Clinical Trials

COVID-19 Vaccination in Patients With Rheumatic Diseases

SAR-CoVAC
Start date: April 20, 2021
Phase:
Study type: Observational [Patient Registry]

The Argentine Society of Rheumatology (SAR) set out to develop a national register of patients with rheumatic diseases who have received a SARS-CoV-2 vaccine in order to assess their efficacy and safety in this population.

NCT ID: NCT04839315 Recruiting - Osteoarthritis Clinical Trials

COVID-19 Vaccination in Rheumatic Disease Patients

Start date: February 15, 2021
Phase: Early Phase 1
Study type: Interventional

The research is being done to study the immune responses to COVID-19 vaccination in patients with rheumatic diseases.

NCT ID: NCT04838574 Not yet recruiting - Chikungunya Clinical Trials

Post-Chikungunya Rheumatism - Rheumatology Follow-up of Patients After 15 Years

ChikRhuma15
Start date: June 2021
Phase:
Study type: Observational

Reunion Island was struck by a severe Chikungunya outbreak in 2005-2006. Three hundred and seven Chikungunya patients were evaluated by 4 rheumatologists 2 months after the initial infection (RHUMATOCHIK study). Eighty-three percents still reported joint pain and 43% joint swelling in telephone interviews after 32 months (Bouquillard et al., 2018). The primary objective of the present study is to assess and classify precisely persistent Chi-related joint diseases after 15 years, in a second rheumatology examination.

NCT ID: NCT04832022 Recruiting - COVID-19 Clinical Trials

Longitudinal Follow-up of Patients With Chronic Inflammatory Rheumatisms (CIRs) Vaccinated Against COVID-19 Compared to Patients Refusing Vaccination

COVID-RIC3
Start date: April 7, 2021
Phase:
Study type: Observational

To date, studies on SARS-CoV2and vaccines have been mostly from the general population not exposed to immunosuppressants. The efficacy and safety of COVID-19 vaccines need to be evaluated in these populations.

NCT ID: NCT04817072 Not yet recruiting - Mood Disorders Clinical Trials

Evaluation of Mood Disorders Under Biologics in Chronic Inflammatory Rheumatic Disease

EMOTION
Start date: April 2021
Phase: N/A
Study type: Interventional

Chronic inflammatory rheumatic diseases (CIRD) affect many organ systems. Painful sensations within the joints spine, hand and foot deformities, low quality of life and psychosocial status in patients with rheumatoid arthritis, spondyloarthritis and psoriatic arthritis can lead to the development of anxiety and depression. Prevalences of anxiety increase in patients suffering of CIRD, compared with healthy individuals. Another connection has been identified by the links between depression and systemic inflammation. It is proven that higher plasma levels of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNFa) affect neurotransmitter metabolism, with influence on patients mood. The purpose of EMOTION study is therefore to analyze thymic variation under TNFa therapy, as treatment of CIRDs.

NCT ID: NCT04806867 Completed - Clinical trials for Rheumatoid Arthritis

Selection of Patients With Chronic Inflammatory Rheumatism Requiring Management During the COVID-19 Pandemia

SePaRIC
Start date: May 1, 2020
Phase:
Study type: Observational

The project proposes to evaluate a strategy for prioritizing teleconsultation for patients with chronic inflammatory rheumatic diseases during the COVID-19 pandemia. This selection will be done through telephone contact by medical students, supervised by residents and rheumatologists on a patient database. The other objectives are to assess the impact of the pandemia on the physical and mental health of patients classified as being at risk

NCT ID: NCT04806113 Recruiting - Clinical trials for Rheumatoid Arthritis

COVID-19 Vaccine in Immunosuppressed Adults With Autoimmune Diseases

COVIAAD
Start date: March 11, 2021
Phase: Phase 3
Study type: Interventional

This study will evaluate the Moderna RNA-based COVID-19 vaccine currently approved by Health Canada in people with rheumatic diseases. This study will help understand what the side effects of the vaccine in these patients are, and what is their capacity to develop antibodies that may confer protection from the COVID-19 disease.

NCT ID: NCT04798053 Recruiting - Covid19 Clinical Trials

Impact of COVID-19 Pandemic and Social Distancing on Mental Health of Chronic Inflammatory Rheumatism Affected Patients

EMOPTION
Start date: April 8, 2021
Phase: N/A
Study type: Interventional

Recent studies have highlighted the consequences of COVID-19 pandemic and social distancing on mental health of individuals. The aim of this study is to evaluate those consequences within a sample of inflammatory chronic rheumatism affected patients, taking into account the well-known key role of stress in the set-up of such diseases.

NCT ID: NCT04780607 Recruiting - Clinical trials for Outcomes of Mitral Valve Surgery in Patients Affected by Rheumatic Heart Disease

Outcomes of Mitral Valve Surgery in Patients Affected by Rheumatic Heart Disease

Start date: January 1, 2011
Phase:
Study type: Observational [Patient Registry]

rheumatic heart disease remains the majority valvular disease in low and middle income countries, which mostly affected mitral valve, surgical treatment is the most effective strategy to improve the outcomes of middle or late-stage RHD patient, however, whether mitral valve repair surgery is superior to replacement or other evolving interventional device remains controversial, this study aims to investigate the results of repair surgery compared with replacement or other treatment strategy from international multicenters.