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Rheumatic Diseases clinical trials

View clinical trials related to Rheumatic Diseases.

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NCT ID: NCT05698251 Completed - Rheumatic Diseases Clinical Trials

Reducing Uncertainty Distress in Long Term Health Conditions

Start date: March 16, 2022
Phase: N/A
Study type: Interventional

The goal of this pilot intervention study is to develop and test a new psychological therapy model in people with long term health conditions (rheumatic conditions) who are experiencing distress (anxiety or low mood) in relation to the uncertainty that their illness causes. The main questions the study aims to answer are: 1. Does the new treatment model help participants reduce uncertainty distress associated with their health condition? 2. Is it a practical treatment that can be ran within a hospital setting? 3. Is the treatment acceptable to participants? Participants will be asked to attend weekly therapy sessions (up to a maximum of 16 sessions) in the hospital or via telehealth. The sessions will be based on the new treatment model and aimed at helping participants reduce uncertainty where they can and learn to live alongside it where it cannot be reduced. The hope is that if participants can better manage uncertainty this will reduce the distress (anxiety or low mood) that they feel.

NCT ID: NCT05693545 Not yet recruiting - Clinical trials for Rheumatic Heart Disease

GOALIE: Intramuscular vs. Enteral Penicillin Prophylaxis to Prevent Progression of Latent RHD Trial

Start date: February 1, 2023
Phase: Phase 2
Study type: Interventional

The goal of this clinical trial is to determine if twice daily oral penicillin prophylaxis is non-inferior to monthly IM penicillin prophylaxis in preventing latent Rheumatic Heart Disease Progression in children between the ages of 5-17 years. The main objective is to compare the proportion of children aged 5-17 years with latent RHD receiving oral penicillin prophylaxis who progress to worse valvular disease at 2-years compared to children who receive IM penicillin prophylaxis.

NCT ID: NCT05682196 Not yet recruiting - Clinical trials for Rheumatic Heart Disease in Children

Rituximab in Patients With Acute Rheumatic Fever

AGRAF-2
Start date: February 1, 2023
Phase: Phase 2
Study type: Interventional

Acute Rheumatic Fever is an autoimmune inflammatory post-infectious syndrome, mainly caused by type A streptococcus. It is characterized as an inadequate immune response. It may provoke carditis, combined with articular, skin and neurologic signs. Only carditis, prevalent in 60% of acute rheumatic diseases, may provoke valvular sequels, which define rheumatic cardiopathy. Antibiotherapy based on penicillin is the standard treatment of both acute rheumatic fever and its prevention. Although no anti-inflammatory treatment has proved its efficacy, with or without steroids anti-inflammatory treatments are administered in acute episode of ARF. Up to date, only prevention strategies have shown efficacy.

NCT ID: NCT05680610 Recruiting - Clinical trials for Follow up of Moderate Aortic Regurge After Rheumatic Mitral Valve Replacement

Follow up of Moderate Aortic Regurge After Mitral Valve Replacement

Start date: August 1, 2022
Phase:
Study type: Observational

Aim of the study is to follow of of moderate aortic regurge after mitral valve replacement to figure out if the aortic regurge has been improved or it is getting worse

NCT ID: NCT05676359 Not yet recruiting - Rheumatic Disorder Clinical Trials

Knowledge of Living Will in Patients With Rheumatic Diseases

Start date: February 1, 2023
Phase:
Study type: Observational

The living will is a legal document derived from a communication and deliberation process, medical ethical aspect, currently regulated in Mexico by the General Health Law and the Health Law of Mexico City. Knowledge of living will in the population with chronic diseases, including rheumatic diseases, has been little addressed. Most patients do not know what the living will document is, so they do not carry it out and others, despite knowing it, have a passive attitude toward doing it.

NCT ID: NCT05668611 Not yet recruiting - Clinical trials for Rheumatic Heart Disease

Train the Trainer Curriculum to Scale up AI Supported Echo for RHD Screening in a Public Health System

ADD-RHD 2B
Start date: January 3, 2023
Phase: N/A
Study type: Interventional

The first primary objective of this study is to determine the diagnostic performance (sensitivity and specificity) of primary MOH nurses who have completed certification in focused echocardiography acquisition and interpretation by expert trainers to accurately identify patients who are screen positive and screen negative for rheumatic heart disease. The second primary objective is to determine the diagnostic performance (sensitivity and specificity) of secondary MOH nurses who have completed certification in focused echocardiography acquisition and interpretation by MOH nurse trainers to accurately identify patients who are screen positive and screen negative for rheumatic heart disease.

NCT ID: NCT05666115 Active, not recruiting - Arthritis Clinical Trials

Efficacy of Modification of Lifestyle in the Treatment of Ankylosing Spondylitis: a Pilot Study

EMLAS
Start date: January 2, 2023
Phase: N/A
Study type: Interventional

Axial spondyloarthritis (axSpA) is a chronic inflammatory immune disorder with a global prevalence that ranges from 20 to 160 cases per 10000 individuals. axSpA has two forms of clinical presentation (radiographic and non-radiographic) based on the presence or absence of radiographic sacroiliitis. This condition mostly affects the vertebral spine, and is characterized by joint pain and stiffness, fatigue, and restricted function, which leads to a substantial physical, psychological, and socioeconomic burden. The clinical management of axSpA needs to combine pharmacological and non-pharmacological approaches to reduce inflammation and improve health-related quality of life. The aim of the study will be to determine if a 12-week probiotic supplementation will be more effective than an online-delivered strength training program at improving functional capacity in adults with non-radiographic axSpA. As a secondary aim, we will compare the impact of both interventions on disease activity, spinal mobility, quality of life and biochemical measures. This will be the first randomized controlled trial where probiotics are compared with an active intervention.

NCT ID: NCT05637411 Active, not recruiting - Obesity Clinical Trials

GeoHealth: Geographic Information System for Health Management and Clinical, Epidemiological and Translational Research

Start date: December 9, 2020
Phase:
Study type: Observational

The objective of the project is to develop a potentially marketable system for clinical, epidemiological and translational research capable of associating contextual variables and geospatial data with clinical patient information. The GeoHealth system will include a section to perform exploratory analysis that will help identify risk factors to optimize clinical decision making. The system will be used in a study of the influence of environmental factors in more than 800,000 asthmatic patients in the region of Andalucía, Spain. The results of this study will help to develop predictive models of risk of exacerbation in asthma patients. Currently, disease management guidelines state that asthma control has two components: current disease control and future risk of exacerbations. These two components are key when assessing disease management, following a stepwise model that seeks to improve current control and minimize future risk. However, although the current control of the disease is defined and has established methodologies for its measurement (Asthma Control Test -ACT- and Asthma Control Questionnaire -ACQ-), the risk of suffering exacerbations is not yet a measurable component. Therefore, these predictive models could help in professional decision making for asthmatic patients. The predictive models will be validated prospectively and implemented in a decision support system for the management of asthmatic patients.

NCT ID: NCT05621369 Recruiting - Psoriasis Clinical Trials

Psorcast Mobile Study

Start date: January 1, 2022
Phase:
Study type: Observational

The purpose of this study is to understand variation in the symptoms of psoriasis and psoriatic arthritis using simple, scalable smartphone-based measurements. This study uses an iPhone app to record these symptoms through questionnaires and sensors.

NCT ID: NCT05618782 Recruiting - Pain Clinical Trials

Clinical Trial to Evaluate the Efficacy and Safety of LEVI-04 in Patients With Osteoarthritis of the Knee

Start date: October 17, 2022
Phase: Phase 2
Study type: Interventional

This is a phase 2, randomized, double-blind, placebo-controlled trial of multiple doses and multiple administrations of LEVI-04 for the treatment of pain due to osteoarthritis of the knee.