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Weight Loss clinical trials

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NCT ID: NCT03361644 Not yet recruiting - Weight Loss Clinical Trials

The Role of High Intensity Interval Training in the Treatment of Adolescent Obesity

Start date: December 2017
Phase: N/A
Study type: Interventional

The study will compare the effects of High Intensity Interval Training (HIIT) with Moderate Intensity Continuous Training (CMIT) as part of a lifestyle intervention program on BMI change in adolescents age 12-16 with obesity.

NCT ID: NCT03353220 Not yet recruiting - Clinical trials for Overweight and Obesity

Predictors of Lorcaserin-Induced Weight Loss

Start date: December 18, 2017
Phase: Phase 4
Study type: Interventional

This two-phase study aims to explore ways to predict who will respond well to the weight loss drug lorcaserin and to understand the mechanisms that develop which limit drug efficacy. Subjects will be recruited for a 5-week crossover study (phase 1) with lorcaserin and placebo followed by treatment with lorcaserin for 24 weeks (phase 2).

NCT ID: NCT03342274 Not yet recruiting - Weight Loss Clinical Trials

Adapting the Diabetes Prevention Program for a Developing World Context

Start date: February 2018
Phase: N/A
Study type: Interventional

This study will examine whether an adapted version of ]he Diabetes Prevention Program (DPP) can be effective when delivered by community health workers (CHWs) in a poor urban community in South Africa. We will randomize existing groups that are part of an non-governmental organization's (NGO) chronic disease management program (anticipated cluster N = 54; anticipated individual N=540), to receive either the program or usual care (wait-list). The primary outcome analysis will compare percentage of baseline weight loss at Y1 between the program and usual care; however, after Y1 usual care participants will also receive the program and both groups will be followed for another year.

NCT ID: NCT03341429 Not yet recruiting - Obesity Clinical Trials

Evaluation of Liraglutide 3.0mg in Patients With Poor Weight-loss and a Suboptimal Glucagon-like Peptide-1 Response

BARIOPTIMISE
Start date: April 2018
Phase: Phase 4
Study type: Interventional

A double-blinded, randomised, placebo-controlled trial of liraglutide 3.0 mg in patients with poor weight-loss and a suboptimal glucagon-like peptide-1 response following bariatric surgery

NCT ID: NCT03338296 Recruiting - Obesity Clinical Trials

Study to Evaluate the Efficacy and Safety of Belviq XR® in Conjunction With Lifestyle Modification for Weight Loss in Obese Adolescents, Age 12 to 17 Years

Start date: September 28, 2017
Phase: Phase 4
Study type: Interventional

This study will be conducted to demonstrate weight loss efficacy by change in body mass index (BMI) during 52 weeks of treatment with Belviq XR 20 milligrams (mg) administered once daily (QD) as compared to placebo.

NCT ID: NCT03337230 Not yet recruiting - Obesity Clinical Trials

Feasibility of a Social Media-based Weight Loss Program for Low Socioeconomic Status Individuals

Start date: November 2017
Phase: N/A
Study type: Interventional

The purpose of this study is to see if it is practical to use social media-based and traditional online weight loss intervention components among low socioeconomic status participants using the Facebook social media (SM) and Fitbit self-monitoring platforms. Also, the study will test the effectiveness of recruiting participants via social media and at community events and locations. The results of this study will be used to inform future research studies.

NCT ID: NCT03337139 Recruiting - Obesity Clinical Trials

FitLink: Improving Weight Loss Maintenance by Using Digital Data to Provide Support and Accountability

Start date: November 2017
Phase: N/A
Study type: Interventional

Most adults in the U.S. are overweight or obese and find maintenance of weight loss difficult. This study is designed to aid in the development of a lifestyle modification program that can facilitate weight loss maintenance, without requiring long-term visits to a clinic for maintenance treatment.

NCT ID: NCT03336086 Completed - Weight Loss Clinical Trials

Effect of Weight Reduction on Immunity

Start date: March 20, 2012
Phase: Phase 3
Study type: Interventional

This study included two groups of premenopausal healthy obese women. Experimental group underwent a weight loss program involved a low calorie diet plus anti-obesity drugs and moderate physical activity and control group underwent an ad libitum diet. At baseline and after a 10-15% weight loss lymphocyte subgroups were analyzed and compared between two group.

NCT ID: NCT03329079 Not yet recruiting - Weight Loss Clinical Trials

Engaging Rural Men With Mobile Technologies for Weight Loss

Start date: January 2018
Phase: N/A
Study type: Interventional

Overweight and obese men in rural Northeast Nebraska are an unrepresented, at-risk group exhibiting rising rates of cardiovascular disease, poor access to preventive care, and a rural milieu that contributes to their sedentary physical activity and unhealthy diet. This study proposes to use a pragmatic randomized controlled trial and community engaged research approaches to 1) determine the feasibility and acceptability of a smart phone self-monitoring app (Lose-It Premium) plus text-based coaching and daily weighing via Wi-Fi scale intervention for achieving weight loss, 2) determine preliminary efficacy of this intervention group to a comparison group receiving only a self-monitoring app (Lose-It Basic) in achieving the outcomes of weight loss (kilogram) and improved dietary and physical activity behaviors (secondary) at 3 and 6 months post-baseline, and 3) determine quantitative and qualitative indicators of community capacity to support a contextually relevant weight loss intervention. Eighty men (ages 40-65) with body mass index of 28-45, randomly assigned (1:1 ratio) to intervention group or comparison group. Men will complete baseline assessments (weight, % body fat, body mass index height, blood pressure, health history, dietary intake, physical activity frequency/intensity) and receive orientation to the mobile technologies (Lose-It app features, text messaging, Wi-Fi scale). Men will track their dietary intake, physical activity, and weight on the Lose-It app for 12 weeks. After the 3-month intervention, post-measure assessments (weight, % body fat, BMI, dietary intake, PA frequency/intensity, technology usability surveys) will be collected at 3 and 6 months post-baseline. At 6 months post-baseline, two groups (n=8 each) of intervention completers will be purposively selected to share their perceptions of the intervention efficacy in an evaluative focus group. A community advisory board comprising local leaders within the men's social network, together with investigators and rural student nurses will guide community outreach efforts for study recruitment, implementation and evaluation. Study findings will be evaluated with the community to inform local dissemination, future intervention revision, and determination of community capacity for support of a larger clinical trial.

NCT ID: NCT03326284 Recruiting - Protein Metabolism Clinical Trials

Protein Intake During Weight Loss

Start date: August 1, 2017
Phase: N/A
Study type: Interventional

The primary aim of the trial is to determine the optimal dose of protein per meal in relation to enhancing muscle protein synthesis and thereby in perspective counteract muscle loss during weight loss. In addition, we aim to determine whether the response to protein intake is reduced in women on hypocaloric diet compared to in women on an energy-balanced diet.