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Weight Loss clinical trials

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NCT ID: NCT03962699 Not yet recruiting - Obesity Clinical Trials

Impact of Weight Loss on the Human Sperm Epitranscriptome

Start date: July 2019
Study type: Observational

Increasing evidence suggests that non-communicable diseases such as in particular obesity and its associated metabolic diseases are inherited from parents to children throughout several generations by epigenetic mechanisms. Thus, this environmental stress would induce epigenetic modification in the germ line that once transmitted and maintained in the progeny would induce the development of the parental pathologies. Considering the increasing prevalence of these pathologies worldwide, we urgently need to understand this process in human. Based on published and unpublished data demonstrating that sperm RNAs are vectors of epigenetic inheritance of obesity mouse model, the investigative team hypothesizes that epitranscriptome of obese men play a central role in the paternal epigenetic inheritance of obesity and its associated metabolic diseases as epigenetic vectors in this process. To validate this hypothesis, the investigative team will use sperm from non-obese and obese men taken before and after surgery weight loss. Thanks to these cohorts, they propose to: (i) compare the epitranscriptome profiles of non-obese and obese men to identify the RNAs molecules which will be either qualitatively or quantitatively epigenetically modulated by obesity; (ii) compare the epitranscriptome profiles of obese men before and after surgery-weight loss to assess the reversibility of the newly acquired RNA modifications. Giving some answers to this central question will provide not only some clues about the molecular mechanisms involved in this process, elements which might be crucial to stop the spread of this disorder, but will also allow the identification of obese-susceptibility loci which expression may be modulate by environmental factors and consequently able to transmit the disease.

NCT ID: NCT03962205 Recruiting - Obesity Clinical Trials

Promoting Weight Loss and Psychological Well-being in Obese Patients

Start date: September 10, 2018
Phase: N/A
Study type: Interventional

The goal of the proposed research is to assess the effects of a sequential combination of lifestyle and well-being intervention on weight loss and psychological well-being. It is hypothesized that psychological well-being promotion as an adjunct to life-style intervention will outperform life style intervention alone in promoting weight loss and psychological well-being in obese individuals.

NCT ID: NCT03936699 Recruiting - Weight Loss Clinical Trials

ELIRA 2: Safety and Effectiveness of TENS Assisted Weight Loss and Appetite Suppression

Start date: June 22, 2018
Phase: N/A
Study type: Interventional

The objectives of this study are to demonstrate safety and effectiveness of a wearable patch TENS system (Appendix 2) in driving weight loss and appetite suppression when coupled with an integrated weight loss reduction strategy. The study is designed to demonstrate that TENS stimulation sufficient to drive weight loss and appetite suppression is safe and tolerable when compared to standard of care, and that adverse events/adverse device effects are similar to other TENS device use cases.

NCT ID: NCT03929198 Completed - Obesity Clinical Trials

Translation of Pritikin Program to the Community

Start date: September 27, 2018
Phase: N/A
Study type: Interventional

The broad, long-term aims of this scope of work are to investigate the effects of the Pritikin Program to the general population. The study will test the effects on individuals from the community with dysfunctional lipids, blood pressure and glycemic control. To assess the effectiveness of the Pritikin Program in the community, the effects of Pritikin lifestyle intervention on overall health will be investigated.

NCT ID: NCT03928483 Active, not recruiting - Obesity Clinical Trials

Evaluation of a Commercial Program on Weight Loss and Health Outcomes

Start date: March 18, 2019
Phase: Early Phase 1
Study type: Interventional

To examine weight loss and acceptability of a modified WW program. This study is designed to detect differences in weight loss at the end of 24 weeks of intervention.

NCT ID: NCT03918564 Recruiting - Obesity Clinical Trials

ReShape Vestâ„¢ for the Treatment of Obesity (Europe)

Start date: March 25, 2019
Phase: Phase 2/Phase 3
Study type: Interventional

To assess the safety and effectiveness of the LGV in treating obese subjects with a BMI of 35 kg/m2 to 55 kg/m2 who have failed one or more conservative weight-reduction alternative(s), such as supervised diet, exercise, and behavior modification program(s).

NCT ID: NCT03883191 Recruiting - Obesity, Childhood Clinical Trials

Effect of a Three Combined Probiotics Supplementation on Weight Loss in Obese/Overweight Children

Start date: October 24, 2017
Phase: N/A
Study type: Interventional

This program is a double-blind, randomized, placebo-controlled study. Investigators expect to enroll 100 overweight or obese children those ages 6 to 18 years. A product that containing three probiotics will be prescribed for study group for 12 weeks plus diet and exercise guidance, while the control group will be given a placebo plus diet and exercise guidance.

NCT ID: NCT03882736 Recruiting - Weight Loss Clinical Trials

Volumetric Study of the Buttocks After Flap Augmentation in Buttocks Lifting

Start date: February 20, 2019
Study type: Observational

The development of bariatric surgery, its effectiveness and the reduction of complications are at the origin of massive weight loss, the corollary of which has been a clear increase in the demands of treatment of sequelae of weight loss.

NCT ID: NCT03881540 Completed - Obesity Clinical Trials

Efficacy of tDNA Care on Weight Loss and Metabolic Outcomes in Patients With Overweight, Obesity and Type 2 Diabetes

Start date: June 2014
Phase: N/A
Study type: Interventional

The aim of this study was to investigate the effectiveness of structured lifestyle intervention following a transcultural diabetes nutrition algorithm (tDNA) care compared to usual diabetes care in patients with overweight, obesity and type 2 diabetes (T2D), receiving either the motivational interviewing counseling or conventional counselling technique in an outpatient clinic setting. The hypothesis is weight loss and glycated haemoglobin (A1C) level will be improved in patients following the tDNA care compared to usual diabetes care and the improvements will be greater in those receiving motivational interviewing counseling than conventional counselling.

NCT ID: NCT03874988 Not yet recruiting - Obesity Clinical Trials

Building an Evidence Base for Weight Loss Strategies Among Those With Chronic SCI-The GLB-SCI+

Start date: June 2019
Phase: N/A
Study type: Interventional

This study's overarching aim is to follow a systematic approach that incorporates community-based participatory research (CBPR) to develop a multi-component weight loss intervention that may yield significant effects for a chronic SCI sample. The approach is to obtain data on the 3 unique strategies (prepackaged/portion-controlled meals; enhanced self-monitoring; the GLB-SCI) to inform design of an empirically supported and consumer-validated multicomponent intervention program, that combines the best of the 3 approaches into one unique intervention, the GLB SCI+. Based on the investigators' prior experience with adapting and delivering the GLB AIM (a lifestyle intervention previously adapted for those with impaired mobility), interim findings, existing literature, and consumer feedback, they hypothesize that these 3 unique strategies may confer individualized benefits to people with SCI given their complex disability-related barriers to weight loss.