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Weight Loss clinical trials

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NCT ID: NCT03560635 Recruiting - Clinical trials for Overweight and Obesity

Feasibility and Preliminary Efficacy of a Reverse Diet as a Novel Weight Loss Maintenance Strategy for Weight-Reduced Adults With Overweight/Obesity

Start date: February 14, 2018
Phase: N/A
Study type: Interventional

The purpose of this project is to test, for the first time, a reverse diet in adults with current or prior overweight/obesity (Ow/Ob). Weight-reduced adults with current or prior Ow/Ob will be randomized to a reverse diet or "standard care" control (CON) intervention for 12 weeks. Eligible participants will have lost >10% body mass. The reverse diet group will receive personalized caloric intake goals, increasing 2-3%/week. The CON group will receive standard weight maintenance recommendations with matched contact. At baseline and week 12, resting energy expenditure (REE), body mass and composition, subjective appetite, and food intake behaviors will be evaluated. In addition to the pre- and post-intervention measures, body mass and adherence to reverse diet will be monitored weekly.

NCT ID: NCT03560375 Recruiting - Clinical trials for Diabetes Mellitus, Type 2

Mediterranean Diet, Circuit Resistance Training, Empagliflozin in Elderly With Type 2 Diabetes: a Study Protocol

Start date: May 9, 2018
Phase: Phase 4
Study type: Interventional

Primary objective: To assess the effects of a modified plant-based Mediterranean diet (vegeterranean diet), circuit resistance training (CRT) and empagliflozin alone or in combination on body composition and physical function in elderly subjects with type 2 diabetes. The rationale for this study is to assess three interventions associated with a negative energy/caloric balance (increased caloric use in exercise, caloric restriction in the vegeterranean diet and caloric wasting by glycosuria with empagliflozin), their interaction and effect on body composition and physical function. Methods and analysis: One hundred and twenty men and women ≥ 65 years of age with type 2 diabetes, and low levels of physical activity will be randomized (1:1:1 manner, gender-stratified) for 10 weeks to one of 3 parallel arms: CRT consisting of 3 home sessions/week; ad-libitum plant-based Mediterranean diet (limited consumption of eggs, dairy and fish, avoidance of red meat and poultry) or empagliflozin 10mg/day. After 10 weeks CRT will be added to the empagliflozin or diet arms for an additional 10 weeks. Allocation concealment and blinding of primary outcome assessors will be implemented. Efficacy will be determined by assessment of lean body mass, body weight, frailty status, sarcopenia, HbA1c and quality of life questionnaires. Safety will be evaluated by routine monitoring of adverse events. This study was approved by the Tel-Aviv Sourasky Medical Center Institutional Review Board

NCT ID: NCT03558685 Active, not recruiting - Obesity Clinical Trials

Weight Loss Diet in Obesity With Metabolic Syndrome

Start date: July 2008
Phase: N/A
Study type: Interventional

Concomitant interventions included lifestyle modification with a personally tailored program of diet as detailed below and physical activity adjusted for age and specific physical limitations, targeting engagement in physical activity of at least 150 minutes/week. Lipid lowering and or blood pressure lowering drugs were prescribed as needed according to guideline-assisted medical practice. Patients were seen by a physician every 3 month. The dietitian had a weekly meeting with the patients for the first three months, every other week during months 4-6, once a month during month 7-9 and every 6 weeks during the last three months of the study.

NCT ID: NCT03558360 Not yet recruiting - Clinical trials for Bariatric Surgery Candidate

Preoperative Dry Lean Body Mass as a Prognostic Factor for Excess Weight Loss After Bariatric Surgery.

Start date: September 1, 2018
Study type: Observational

Bariatric surgery is currently the only method that has proven long-term effectiveness in obesity. Although the benefit of physical activity on weight loss has been demonstrated, no correlation has ever been reported between preoperative lean body mass and postoperative weight loss. Dry lean mass is probably an essential prognostic factor for the effectiveness of bariatric surgery. The main objective of this study is to define a preoperative dry lean body mass threshold as a worst prognostic factor for weight loss one year after bariatric surgery. The management of patients included in this study was modelled on the management usually offered to patients followed for the same pathology in the diabeto-endocrinology department. There are no study-specific examinations that are not part of current practice.

NCT ID: NCT03557424 Completed - Weight Loss Clinical Trials

BEFORE Study, Efficacy of Refigura

Start date: April 26, 2017
Phase: Phase 4
Study type: Interventional

The BEFORE study ((B) EFficacy Of REfigura) is designed to demonstrate the efficacy of REFIGURA®. It is a double-blind, randomized, monocentric study.

NCT ID: NCT03554525 Active, not recruiting - Obesity Clinical Trials

Weight Regain After Consumption of Food Supplement and Interventional Diet Program

Start date: April 1, 2017
Phase: Phase 3
Study type: Interventional

Effect of the dietary supplement (FAT-BINDER DAMM) on weight regain after 9 months of control weight program

NCT ID: NCT03553927 Recruiting - Obesity Clinical Trials

Investigating the Physiological Effects of Weight Loss on Male Fertility

Start date: May 16, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to determine the physiological effects of weight loss on seminal parameters in male participants with reduced reproductive capacity. Learning more about the physiological role of weight loss on reproductive function and metabolic profile of overweight and obese men may give us a better understanding of male fertility and improve the management of patients with reduced fertility. The effects of weight loss on seminal quality are not well understood.

NCT ID: NCT03553160 Completed - Healthy Clinical Trials

Caloric Titration Method of Weight Loss and Maintenance

Start date: August 16, 2010
Phase: N/A
Study type: Interventional

Study examined the effectiveness of daily self-weighing to prevent age related weight gain.

NCT ID: NCT03552107 Active, not recruiting - Obesity Clinical Trials

Lorcaserin: Real World Experience in an Insurance-Based Weight Management Clinic

Start date: April 11, 2017
Study type: Observational

This is a retrospective, descriptive study that involves de-identified data consisting of weight changes, pertinent vital signs and laboratory values influenced by body weight, and healthcare utilization of patients prescribed lorcaserin at The Center for Weight Management at the Scripps Clinic in San Diego, CA.

NCT ID: NCT03550339 Active, not recruiting - Obesity Clinical Trials

Regulation of Energy Balance and Metabolism - Mechanisms Behind and Beyond Obesity and Weight Loss

Start date: November 2016
Phase: N/A
Study type: Interventional

The study aims to investigate homeostatic and hedonic mechanisms regulating appetite, energy balance and metabolism in obesity and the effects of three distinct obesity treatments on these regulatory mechanisms.