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Vasodilation clinical trials

View clinical trials related to Vasodilation.

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NCT ID: NCT06301880 Completed - Vasodilation Clinical Trials

Effect of Topically-applied Milrinone or Nitroglycerin on Internal Mammary Artery Free Flow

Start date: January 1, 2022
Phase: Phase 3
Study type: Interventional

Forty-six consecutive patients undergoing elective primary coronary artery bypass grafting were enrolled. After the left IMA was harvested, free flow was measured under controlled hemodynamic conditions before any intervention (flow 1) and at a mean of 12.5 minutes after the topical application of one of three agents (milrinone, nitroglycerin or normal saline) on the IMA (flow 2).

NCT ID: NCT06290713 Not yet recruiting - Exercise Clinical Trials

Vasodilator and Exercise Study for DMD (VASO-REx)

Start date: March 2024
Phase: Phase 2
Study type: Interventional

Examining two strategies as potential adjuvant therapies for Duchenne muscular dystrophy (DMD); aerobic exercise training (to induce adaptations in skeletal muscle and improve cardiovascular health) and tadalafil, an FDA-approved vasodilator (to optimize blood flow and muscle perfusion which is impaired and often overlooked in DMD). Target: improved muscle function, vascular health, and DMD treatment.

NCT ID: NCT06236243 Recruiting - Clinical trials for Cardiovascular Diseases

Effect of Korean Red Ginseng Extract on Blood Flow in Healthy Adults

Start date: January 31, 2024
Phase: N/A
Study type: Interventional

The objectives of this clinical trial are to 1) determine the effect of the TP compared to placebo on blood flow and platelet aggregation, 2) to determine the effect of the TP on cardiovascular health compared to a placebo and 3) to assess the safety and tolerability of the TP in healthy adults.

NCT ID: NCT06117007 Recruiting - Quality of Life Clinical Trials

Effects of Betalains on Cardiovascular Health and Quality of Life

Start date: October 30, 2023
Phase: N/A
Study type: Interventional

The goal of this randomized, double-blind, placebo-controlled, cross-over trial is to investigate the effects of beetroot-derived betalains on cardiovascular health, sleep and quality of life in healthy middle-aged individuals. The main question[s] it aims to answer are: - Do betalains improve vascular function? - Do betalains improve sleep? - Do betalains improve quality of life? Participants will be involved with the following: - Consuming a daily betalain-rich or placebo capsule for a month - Non-invasive cardiovascular measurements - Wearing a fitness tracker for tracking physical activity and sleep - Answering questionnaires regarding quality of life Researchers will compare results between the intervention versus the placebo group to see if any of the study outcomes are significantly different.

NCT ID: NCT05997732 Recruiting - Vasodilation Clinical Trials

Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences

STARS
Start date: October 31, 2023
Phase: Phase 4
Study type: Interventional

The main purpose of this interventional study is to examine differences in resting blood pressure control between healthy males and females. The main questions it aims to answer are: 1. Are there sex differences in the communication between the sympathetic nervous system (also known as the "fight or flight" response) and peripheral blood vessels (which influence systemic blood pressure)? 2. What is the role of specific vascular receptors that respond to sympathetic signals, and is it different between males and females? Participants will complete one study visit of approximately 3 hours where they will: - Have a blood sample taken to measure circulating sex hormone and sympathetic transmitters. - Receive very small doses of medications commonly used to adjust blood pressure through an artery in their arm. The effects of these medications will be short-acting and localized to the forearm. - Have their sympathetic nervous activity directly measured through two very small needles (similar to acupuncture needles) in the side of their leg. - Have their blood pressure and heart rate recorded, and forearm blood flow measured using ultrasound.

NCT ID: NCT05525416 Completed - Vasodilation Clinical Trials

Sex Differences in Sympathetic Vascular Reactivity at High Altitude

Start date: July 28, 2022
Phase: N/A
Study type: Interventional

This study aims to investigate sex differences in blood pressure control associated with exposure to acute hypoxia (low oxygen), and short term acclimatization to hypoxia at high altitude.

NCT ID: NCT05522075 Recruiting - Aging Clinical Trials

Reducing Blood Pressure in Mid-life Adult Binge Drinkers

Start date: November 21, 2022
Phase: N/A
Study type: Interventional

This study has two phases: Phase 1 is to examine blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers vs. alcohol abstainers/moderate drinkers. Phase 2 is to examine the effect of 8-week aerobic exercise training on blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers

NCT ID: NCT05492071 Completed - Clinical trials for Diabetes Mellitus, Type 2

Impact of Regional Vibration Application and Flow Mediated Dilation on Brachial Artery Hemodynamics

VMD
Start date: August 8, 2022
Phase: N/A
Study type: Interventional

Application of vibration has been previously shown to affect tissue perfusion and utilized in different branches of medicine. Little is known about the acute impact of vibration application on peripheral artery hemodynamics. In this study, investigators intend to assess: 1. vibration induced hemodynamic changes in brachial artery in non-diabetic patients and compare the characteristics of these alterations with flow mediated dilation mediated changes in same cohort. 2. compare the characteristics of vibration mediated hemodynamic alterations in diabetic and non-diabetic subgroups.

NCT ID: NCT05256069 Recruiting - Hypoxia Clinical Trials

Sex-related Differences in Sympathetic Vascular Transduction in the Setting of Hypoxemia

Start date: April 26, 2023
Phase: Early Phase 1
Study type: Interventional

The purpose of this project is to identify sex-related differences in the effect of hypoxia on sympathetic vascular transduction.

NCT ID: NCT05219799 Recruiting - Healthy Clinical Trials

Sex Disparities in Hypoxic Vasodilation and Impact of Obesity

Start date: March 14, 2023
Phase: Early Phase 1
Study type: Interventional

The purpose of this project is to examine key mechanisms contributing to sex-differences in hypoxic vasodilation and the impact of obesity, with particular emphasis on the sympathetic nervous system.