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Pancreatitis, Chronic clinical trials

View clinical trials related to Pancreatitis, Chronic.

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NCT ID: NCT06055595 Active, not recruiting - Pregnancy Related Clinical Trials

Genetic Factors and CP Pregnancy Outcomes

Start date: January 2010
Phase:
Study type: Observational [Patient Registry]

To explore the impact of chronic pancreatitis (CP) susceptibility genes on pregnancy outcomes.

NCT ID: NCT05764629 Active, not recruiting - Diabetes Mellitus Clinical Trials

An Observational Study on Post-chronic Pancreatitis Diabetes Mellitus

Start date: September 1, 2021
Phase:
Study type: Observational

To explore the risk factors influencing glycemic status, optimized treatment, and prognosis of post-chronic pancreatitis diabetes mellitus (PPDM-C).

NCT ID: NCT05762445 Active, not recruiting - Clinical trials for Chronic Pancreatitis

PAtient-CenTric Chronic Pancreatitis Registry (PACT-CP)

PACT-CP
Start date: June 2, 2021
Phase:
Study type: Observational [Patient Registry]

The main objective of this study is to generate real-world evidence reflecting the experience of individuals with exocrine pancreatic insufficiency (EPI) due to chronic pancreatitis (CP). Efforts will be directed toward understanding the unmet need and therapeutic burden to identify the most critical factors that influence treatment choices/prescribing patterns, quality of life, and healthcare utilization outcomes in standard of care for individuals with EPI due to CP.

NCT ID: NCT05551858 Active, not recruiting - Pain Clinical Trials

Role of a CCK Receptor Antagonist Proglumide in Management of Chronic Pancreatitis

ProCP
Start date: November 17, 2022
Phase: Phase 1/Phase 2
Study type: Interventional

Chronic pancreatitis is a rare but debilitating condition associated with chronic abdominal pain, diarrhea, diabetes, and an 8-fold increased risk for the development of pancreatic cancer. Unfortunately, there is no available treatment to prevent the progression of chronic pancreatitis, and most subjects require narcotic medications to control the pain. A receptor protein call the CCK-B receptor becomes activated in chronic pancreatitis and is in part responsible for the scar tissue or fibrosis that occurs and responsible for the cancer risk. In mice with chronic pancreatitis, the inflammation and damage was reversed with an old drug called proglumide that blocks the activation of the CCK-B receptor. Proglumide has also been shown to possibly reduce pain. This protocol involved a 2-Part study to test the safety of oral proglumide in those with confirmed chronic pancreatitis and the second goal is to determine if proglumide improves pain and function of the pancreas. Part-1 is an open-labelled Lead-in Study of N=8 subjects over a 12-week treatment period. Part-2 is a randomized double blind pseudo cross over study where subjects will be treated in Arm A (placebo for 12 weeks followed by 12 weeks of proglumide) and Arm B ( proglumide for 24 weeks).

NCT ID: NCT05095831 Active, not recruiting - Pancreatitis Clinical Trials

EUS Shear Wave for Solid Pancreatic Lesions.

Start date: October 1, 2021
Phase:
Study type: Observational [Patient Registry]

The diagnosis of pancreas diseases is based on a combination of clinical signs, symptoms, and laboratory tests, but mainly on imaging techniques such as computed tomography (CT) and magnetic resonance (MR). However, CT/MR have variable sensitivity and specificity, with certain disadvantages. Endoscopic ultrasound with elastography is an important resource with higher diagnostic accuracy in assessing solid pancreas lesions. Shear wave velocities of healthy parenchyma, acute, chronic and autoimmune pancreatitis, neoplastic lesions of the pancreas must be evaluated and compared.

NCT ID: NCT05042284 Active, not recruiting - Pain Clinical Trials

Effect of Non-enteric Coated Enzymes Substitution on Pain in Patients With Chronic Pancreatitis

NE-PERT
Start date: September 1, 2021
Phase: N/A
Study type: Interventional

Pain in CP entails several independent yet overlapping mechanisms including oxidative stress-mediated parenchymal inflammation, pancreatic and central neuropathy and neuroplasticity. Medical modalities for long-term pain management includes antioxidants and neuromodulators. Pancreatic enzymes are also invariably used for pain management. CP with ductal obstruction and pain is treated with either endotherapy or drainage surgery. However, it has been observed that a substantially increasing proportion of patients experience pain recurrence as the duration of follow-up after endotherapy or surgery gets longer. Neural and dietary (proteins) stimuli activate CCK receptors in D1 & D2 which gives a positive feedback signal for pancreatic secretion. Once enzyme secretion starts, due to ductal and interstitial/tissue hypertension, nociception begins that results in pain. Blockade of the duodenal CCK receptors could inhibit the positive feedback loop, thereby reducing pancreatic secretion and resulting pain. Currently available enteric coated enzyme supplements are released throughout the small bowel and therefore may not be released sufficiently in the duodenum to effectively suppress the feedback loops. High doses of proteases (~25k-30k) would be required to block the receptors, while most of the currently available preparations have higher lipase but not proteases. This led to the investigators' hypothesis that negative feedback of CCK by non enteric coated pancreatic enzymes could ameliorate pain in a more effective manner by NE-PERT.

NCT ID: NCT04574297 Active, not recruiting - Clinical trials for Chronic Pancreatitis

An Observational Study on the Natural Course of Chronic Pancreatitis

Start date: January 1, 2011
Phase:
Study type: Observational

To explore the impact on genetic and environmental factors for clinical manifestation, and the progression of chronic pancreatitis, including development of pancreatic insufficiency and other complications.

NCT ID: NCT04232670 Active, not recruiting - Clinical trials for Pancreatic Duct Stone

Pancreatic Endotherapy for Refractory Chronic Pancreatitis

PERCePT
Start date: October 9, 2020
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate whether endoscopic ultrasound (EUS) only versus EUS + endoscopic retrograde cholangiopancreatography (ERCP) with pancreatic endotherapy reduces pain in the treatment of chronic pancreatitis with pancreatic duct obstruction.

NCT ID: NCT04158297 Active, not recruiting - Clinical trials for Chronic Pancreatitis

ESWL Versus SOPIL for Treatment of Pancreatic Duct Stones

Start date: November 13, 2019
Phase: N/A
Study type: Interventional

Pancreatic duct stones can cause obstruction of the main pancreatic duct leading to abdominal pain, exocrine pancreatic insufficiency, and recurrent acute pancreatitis. By removing pancreatic duct stones, the obstruction can be relieved, and this can improve symptoms. Small stones can be removed with standard endoscopic retrograde cholangiopancreatography (ERCP) and stone removal, but larger stones may require lithotripsy to break up the stone before removal. The two current methods of lithotripsy include extracorporeal shock wave lithotripsy (ESWL) and single operator pancreatoscopy with intracorporeal lithotripsy (SOPIL). ESWL is based on concentrating shock wave energy to the stone through an external device. SOPIL is a newer technique based on direct visualization of the stone during ERCP and targeting the stone with a shock wave catheter. There are currently no studies directly comparing ESWL to SOPIL for breaking apart stones in the pancreatic duct, so this study is designed to compare the two techniques. Objective #1: Obtain pilot data to determine the optimal method of clearing large MPDS Objective #2: Obtain pilot data to assess how effective large MPDS clearance is in improving long term patient centered outcomes Objective #3: Obtain pilot data to measure the cost effectiveness of large MPDS clearance

NCT ID: NCT04067440 Active, not recruiting - Obesity Clinical Trials

Characterization of the Microbiome in Peritoneum, Jejunum, Rectum and Stool

METABIOM
Start date: October 1, 2019
Phase:
Study type: Observational

Characterization of the human microbiome in the jejunum and comparison to the microbiome in the rectum and stool in order to see how the microbial communities change within the intestines.