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Pancreatitis, Chronic clinical trials

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NCT ID: NCT06278272 Completed - Clinical trials for Chronic Pancreatitis

AI Evaluation of Pancreatic Exocrine Insufficiency in CP Patients

Start date: March 1, 2023
Phase:
Study type: Observational

Early assessment of pancreatic exocrine insufficiency (PEI) is crucial for determining appropriate chronic pancreatitis (CP) treatment plans, thereby avoiding unnecessary suffering and further complications in patients. A total of 504 patients with CP who underwent fecal elastase-1 test and contrast-enhanced CT at Changhai Hospital between January 2018 and April 2023 were enrolled in this study. The investigators aim to establish a fully automated workflow to establish a PEI classification model based on radiomic features, semantic features and deep learning features on enhanced CT images for evaluating the severity of PEI.

NCT ID: NCT06230120 Completed - Chronic Pain Clinical Trials

Spinal Cord Stimulation for the Treatment of Pain in Chronic Pancreatitis

Start date: November 1, 2020
Phase: Phase 2
Study type: Interventional

Chronic pancreatitis leads to severe abdominal pain in up to 70% of patients, and several studies have proposed it has a neuropathic component. Current treatments often fail to provide adequate pain relief, necessitating new innovations for management. Spinal cord stimulation has been proposed to treat severe neuropathic pain refractory to conventional treatment, but sham-controlled trials have not previously been done in patients with visceral pain. This study will test the effect of spinal cord stimulation in chronic pancreatitis patients with insufficient pain relief from standard therapies.

NCT ID: NCT05906615 Completed - Pancreatic Cancer Clinical Trials

Intravenous Lidocaine for Pain Associated With Pancreatic Cancer and Chronic Pancreatitis

LIDOPAN
Start date: January 14, 2021
Phase: Phase 2
Study type: Interventional

Pain is a major clinical problem for many patients with pancreatic cancer and chronic pancreatitis (CP).In pancreatic cancer, nearly 75% of patients suffer from pain at the time of diagnosis, with over 90% of patients in advanced stages. In CP, pain occurs in 80-90% of patients and strongly affects quality of life. For both conditions, the majority of pain is addressed using the WHO analgesic ladder. However, more invasive pain therapies are often necessary. Currently, in several centers in the Netherlands, treatment with IV lidocaine is already used in clinical practice in patients with pancreatic cancer and CP. Based on practical experience, the majority of patients benefit from this therapy, however, its efficacy in terms of duration of pain relief, decrease in pain scores, increase in patient satisfaction and adverse events is unknown. Therefore, the aim of this study is to investigate the efficacy of monitored single intravenous infusion in patients with pancreatic cancer and CP.

NCT ID: NCT05888012 Completed - Clinical trials for Chronic Pancreatitis

Balloon Catheter vs. Basket Catheter in Pancreatic Duct Stone Clearance

Start date: February 1, 2012
Phase:
Study type: Observational

The aim of the study is to compare the safety and efficacy of the basket catheter with that of the balloon catheter for endoscopic extraction of pancreatic stones.

NCT ID: NCT05476978 Completed - Clinical trials for Pancreatic Ductal Adenocarcinoma

Artificial Intelligence in EUS for Diagnosing Pancreatic Solid Lesions

Start date: July 1, 2022
Phase:
Study type: Observational

We aim to develop an EUS-AI model which can facilitate clinical diagnosis by analyzing EUS pictures and clinical parameters of patients.

NCT ID: NCT05132309 Completed - Clinical trials for Chronic Pancreatitis

Intestinal Microbiota Composition in Patients With Chronic Pancreatitis and Pancreatic Exocrine Insufficiency

Start date: November 1, 2020
Phase:
Study type: Observational

Assessment of qualitative and quantitative composition of the intestinal microbiota in patients with CP; in patients with CP and PEI complication of mild to severe degree; patients with CP and PEI who underwent surgical intervention on the pancreas. Intergroup comparison of the microbial compositional characteristics and their analysis. Correction of enzyme replacement therapy in selected groups of patients with regard to the identified microbial characteristics. Assessment of the intestinal microbiota composition in dynamics after 6 (+1) months on the background of allocated therapy

NCT ID: NCT05069597 Completed - Cystic Fibrosis Clinical Trials

Study to Evaluate Symptoms of Exocrine Pancreatic Insufficiency in Adult Participants With Cystic Fibrosis or Chronic Pancreatitis Treated With Creon

Start date: October 14, 2021
Phase: Phase 4
Study type: Interventional

Exocrine pancreatic insufficiency (EPI) is a condition that is caused by the inadequate pancreatic enzymes needed for normal digestion and is commonly associated with a wide range of chronic diseases, including cystic fibrosis (CF), chronic pancreatitis (CP), and pancreatic cancer. This study will assess clinical symptoms when participants with CF or CP are treated with Creon with alternate source of active drug. Creon is an approved drug for the treatment of EPI due to CF or CP. This study is subject-blinded which means participants will not know the source of the study drug they are given. Approximately 30 adult participants with CF or CP will be enrolled at approximately 15 sites across the Unites States. Participants will receive oral capsules of CREON for 112 days and will be followed for 30 days. Participants will attend regular visits during the study at a hospital or clinic or via telemedicine. The effect of the treatment will be checked by medical assessments, checking for side effects and completing questionnaires.

NCT ID: NCT04949828 Completed - Clinical trials for Chronic Pancreatitis

Effect of CREON on Exocrine Pancreatic Insufficiency (EPI) Symptoms

CisCP
Start date: September 16, 2021
Phase:
Study type: Observational

Exocrine Pancreatic Insufficiency (EPI) is a condition where pancreatic enzyme quantity or activity is reduced below threshold needed for normal digestion. Symptoms include bloating, flatulence, diarrhea and steatorrhea. This is an observational study assessing for effect of CREON on symptoms of EPI in participants with EPI due to chronic pancreatitis.

NCT ID: NCT04907266 Completed - Clinical trials for Chronic Pancreatitis

Validation Of Chronic Pancreatitis Prognosis Score (COPPS)

Start date: June 1, 2018
Phase:
Study type: Observational

Clinical course of chronic pancreatitis is still unpredictable, due to the lack of clinical classification. There is no model to assess disease severity or progression or predict patient outcomes. So we need to validate an objective predictive model - Chronic Pancreatitis Prognosis Score (COPPS) for classification, prognostication and management in Chronic Pancreatitis (CP)

NCT ID: NCT04867304 Completed - Depression Clinical Trials

Determinants of Depression and Its Impact on Quality of Life in Patients With Chronic Pancreatitis

Start date: February 1, 2018
Phase:
Study type: Observational

Chronic pancreatitis (CP) is associated with recurrent intractable abdominal pain, pancreatic exocrine insufficiency and endocrine dysfunction. Very few studies had evaluated the quality of life in CP, and even a fewer have assessed the mental status in these patients. In the current study, we proposed to evaluate the the relationship between pain, quality of life and depression status in two large independent cohorts of patients with CP. We also proposed to evaluate the brain metabolites in the right and left anterior cingulate cortex, basal ganglia, hippocampus and prefrontal cortex using magnetic resonance spectroscopy. We further proposed to evaluate the pasta metabolites and look for associations with the mental state. Finally, we proposed to evaluate how CP related education of the patients could impact on their mental status and response to interventions on pain.