ST Elevation Myocardial Infarction Clinical Trial
Official title:
Impact of Ischemic Post-conditioning During Primary Percutaneous Coronary Intervention on Left Ventricular Remodeling and Global Systolic Function in Patients Presenting With ST-Elevation Myocardial Infarction
Verified date | September 2019 |
Source | Assiut University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Study will investigate & compare the left ventricular remodeling & systolic function between two groups of ST-elevation myocardial infarction undergoing primary per-cutaneous coronary intervention applying ischemic post-conditioning to one of them.
Status | Not yet recruiting |
Enrollment | 100 |
Est. completion date | October 15, 2021 |
Est. primary completion date | October 15, 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: 1. Patients presenting with symptoms of acute myocardial ischemia with time of symptom onset < 12 hours & meeting the other following criteria of type 1 myocardial infarction according to the fouth universal definition of myocardial infarction(Thygesen, 2019): - Detection of a rise and/or fall of cardiac troponin values with at least one value above the 99th percentile upper reference limit.(URL) - Ischemic ECG changes; New or persistent ST-segment elevation with development of pathological Q waves - Imaging evidence of new loss of viable myocardium or new regional wall motion abnormality in a pattern consistent with an ischemic etiology. 2. Patients undergoing primary percutaneous coronary intervention as the first choice of revascularization therapy. Exclusion Criteria: 1. Patients with transient ST segment elevation in the surface electrocardiography. 2. Patients presenting within > 12 hours from the onset of maximal symptoms. 3. Patients with evidence of pre-infarction angina. 4. Patients with evidence of collateral blood flow to the infarct region on their angiogram. 5. Patients with history of old myocardial infarction causing chronic impairment of LV systolic function. 6. Patients presenting with ST-segment elevation myocardial infarction other than type 1 according to the fouth universal definition of myocardial infarction |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Assiut University |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Left ventricular Ejection Fraction | is a simple measure of global systolic function that pervades the risk evaluation and management of many cardiovascular diseases | Immediate-6 months | |
Primary | Left ventricular remodeling | percentage of increase in left ventricular end-diastolic volume (EDV) and/or left ventricular end-systolic volume (ESV) | Immediate-6 months |
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