ST Elevation Myocardial Infarction Clinical Trial
Official title:
High PlatElet Inhibition With TicAgrelor to Improve Left Ventricular RemodeLING in Patients With ST-segment ElevAtion Myocardial Infarction: the HEALING-AMI Trial.
The purpose of the study is to evaluate the novel role of ticagrelor to improve long-term LV remodeling following ST-segment elevation myocardial infarction.
The investigators designed the HEALING-AMI study to compare the influence of ticagrelor (180
mg loading and 90 mg twice daily maintenance) vs. clopidogrel (600 mg loading and 75 mg
daily maintenance) on long-term left ventricular (LV) remodeling measured by 3D
echocardiography in STEMI patients undergoing primary PCI.
The primary objective of the HEALING-AMI study is to demonstrate the novel role of long-term
ticagrelor therapy in reducing the risk of LV remodeling,. The secondary objectives are to
reveal the cross-talk between platelet and inflammatory process in ST-segment elevation
myocardial infarction (STEMI) patients. Moreover, this study will determine whether the high
platelet inhibition by ticagrelor culminate the protection of infarcted myocardium.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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