Diabetes Mellitus, Type 2 Clinical Trial
Official title:
Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes (JPAD) Trial
The purpose of this study is to determine the effects of low-dose aspirin for the primary prevention of vascular events in patients with type 2 diabetes in Japan.
There is a worldwide epidemic of diabetes and the number of individuals with diabetes is set
to increase further. As individuals with diabetes are at high risk of accelerated
atherosclerosis and thrombotic vascular events, the significant proportion of the
cardiovascular disease burden is projected to be among this population. JPAD is a
multicenter study with a prospective randomized open, blinded end-point (PROBE) design. The
doses administered are aspirin 81 mg/day or 100 mg/day, the latter being enteric-coated
Aspirin.
The primary objective was to compare the effect of aspirin on atherosclerotic events
including cardiovascular events, cerebral vascular event, and other vascular events.
We also analyze hemorrhagic events in this RCT.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Prevention
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