Diabetes Mellitus Clinical Trial
Official title:
Metabolic Adaptations to Six Month Caloric Restriction
This study is one of three CALERIE trials that test the hypothesis that a reduced calorie, nutritionally sound diet improves biomarkers of aging and prevents some age-related chronic diseases such as cancer, diabetes, and cardiovascular disease. The three sites that are participating in the CALERIE trial represent a diversity of subject populations and interventional strategies.
This study tests whether chronic caloric restriction improves risk factors of longevity in
humans as it is known to do in animals, by measuring a variety of factors dealing with
metabolism and oxidative stress, through physical evaluations and laboratory tests.
Participants will receive dietary counseling and free medical evaluations. In addition, each
volunteer will be asked to do one of the following:
1. Follow a reduced calorie diet
2. Follow a reduced calorie diet using a liquid diet
3. Increase physical activity while on a reduced calorie diet
4. Follow a standard diet.
Three separate five-day inpatient stays are required.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind, Primary Purpose: Prevention
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