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NCT ID: NCT03923699 Completed - Surgery Clinical Trials

Telemedicine Control Tower for the Operating Room: Navigating Information, Care and Safety

TECTONICS
Start date: July 1, 2019
Phase: Phase 3
Study type: Interventional

Medical errors account for thousands of potentially preventable deaths each year. With the annual increase of surgical cases there is a need for research into the potential utility of a telemedicine-based control center for the operating room to assess risk, diagnose negative patient trajectories, implement evidence-based practices, and improve outcomes.

NCT ID: NCT03923582 Completed - Clinical trials for Health Knowledge, Attitudes, Practice

Health Training for Health Professionals In Tanzania

THP
Start date: May 1, 2021
Phase: N/A
Study type: Interventional

The goal of this randomized, controlled, single blinded trial is to evaluate the effectiveness of an Afrocentric sexual health curriculum on health professional students' knowledge, attitudes, and clinical skills in providing sexual health care in Tanzania.

NCT ID: NCT03923530 Completed - Hypertension Clinical Trials

Pressure Assessment to Improve Outcomes After TAVR: a Registry

Start date: June 3, 2019
Phase: Early Phase 1
Study type: Interventional

At the Malcom Randall Veterans Affairs Medical Center (MRVAMC), invasive cardiac pressures are routinely recorded after transcatheter aortic valve replacement (TAVR) procedures. Our research has disclosed that patients with abnormal hemodynamics (narrow aortic to ventricular end-diastolic pressure difference, indexed to heart rate) suffer from high long-term mortality, compared with patients with normal hemodynamics.This hemodynamic value can be referred to as the aortoventricular index (AVi). Hypertension and diastolic dysfunction are highly co-morbid conditions among these patients. The selective aldosterone receptor antagonist eplerenone (Inspra) is approved for use in the treatment of hypertension. Research also supports that eplerenone may be able to improve diastolic function. This prospective study is interested in determining 1) the tolerability of eplerenone, and 2) feasibility of administering the Kansas City Cardiomyopathy Questionnaire (KCCQ-12) among subject with abnormal cardiac hemodynamics after TAVR. This study will set the stage for a pilot randomized trial to evaluate eplerenone versus placebo among patients with abnormal hemodynamics after TAVR.

NCT ID: NCT03923283 Completed - Clinical trials for Other Disorders of the Eye Following Cataract Surgery

The Measurements of End-tidal Carbondioxide Levels

Start date: January 1, 2016
Phase:
Study type: Observational

Purpose: The aim of this retrospective study is to investigate the end tidal carbon dioxide pressure (ETCO2) values in order to determine the carbon dioxide accumulation under drape and to investigate it's hemodynamic effects based on anesthetic and surgical records in eye surgeries under local anesthesia. Methods: The data were collected from anesthetic records of the patients who were followed with noninvasive capnograph (Capnostream 20 p, Oridion®, Israel) by the anesthesiology department in the operating room at Duzce University Faculty of Medicine Hospital during the period of January 2016 to December 2016. Collected data from the 42 patients' records were systolic, diastolic and mean arterial pressures, operation duration, total local anesthetic and, heart rate, ST segment analysis, ETCO2 pressure, pulse oximeter values. The time periods of collected datas were determined as: after the anesthesia and before drape closure (baseline level), at 10th, 15th, 20th, 45th of the surgery and 5 minutes after drape removal.

NCT ID: NCT03922399 Completed - Clinical trials for Patients With Major Burn Injury in Formosa FunCost Explosion

Outcome Evaluation for Burn Scar Therapy-laser and Surgery in Patients in Formosa Fun Coast Explosion

Start date: October 1, 2018
Phase: N/A
Study type: Interventional

Protocol title: Outcome evaluation for burn scar therapy-laser and surgery in patients in Formosa Fun Coast Explosion Objectives: The goal of this study is to evaluate the effectiveness of both lasers and operations on patients with major burn scar(>20% TBSA).

NCT ID: NCT03922308 Completed - Clinical trials for Acquired Thrombotic Thrombocytopenic Purpura (aTTP)

Study of rADAMTS-13 (SHP655) in the Treatment of Participants With Acquired Thrombotic Thrombocytopenic Purpura (aTTP)

SOAR-HI
Start date: October 9, 2019
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the pharmacokinetics, safety, and efficacy of rADAMTS-13 (SHP655) administered in addition to standard of care (SoC) treatment of acquired thrombotic thrombocytopenic purpura (aTTP) participants.

NCT ID: NCT03922087 Completed - Obesity Clinical Trials

No-worry Baby Project

Start date: November 20, 2018
Phase:
Study type: Observational

The Huizhou mother-infant cohort was set up to investigate the effect of dietary factors and environmental exposures during pregnancy on health consequences of mothers and offsprings in Huizhou, China.

NCT ID: NCT03921866 Completed - Clinical trials for HR+/HER2- Locally Advanced, Metastatic Breast Cancer

UK Ibrance Patient Program (IPP) Study

ROIS
Start date: March 1, 2019
Phase:
Study type: Observational

What are the real-world treatment patterns, patients' characteristics, clinical outcomes and healthcare resource utilisation associated with palbociclib treatment in the 3 years following initiation in United Kingdom patients with hormone receptor-positive, human epidermal growth factor 2-negative metastatic breast cancer treated as part of the IPP?

NCT ID: NCT03921775 Completed - Clinical trials for Anesthesia for Elective Surgery Patients

A Clinical Study of Remimazolam Tosilate Compared to Propofol for General Anesthesia During Elective Surgery

Start date: May 13, 2019
Phase: Phase 3
Study type: Interventional

The study is being conducted to evaluate the efficacy and safety of remimazolam tosilate compared to propofol for general anesthesia during elective surgery.

NCT ID: NCT03921450 Completed - Schizophrenia Clinical Trials

Overcoming Psychomotor Slowing in Psychosis (OCoPS-P)

OCoPS-P
Start date: March 25, 2019
Phase: N/A
Study type: Interventional

Psychomotor slowing is a major problem in psychosis. Aberrant function of the cerebral motor system is linked to psychomotor slowing in patients, particularly resting state hyperactivity in premotor cortices. A previous clinical trial indicated that inhibitory stimulation of the premotor cortex would reduce psychomotor slowing. The current study is further exploring this effect in a randomized, placebo-controlled, double-blind design with three arms of transcranial magnetic stimulation and measures of brain imaging and physiology prior to and after the intervention.