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Osteoporotic Fractures clinical trials

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NCT ID: NCT03484208 Recruiting - Clinical trials for Osteoporotic Fractures

Evaluation of a Fracture Liaison Service in the Osteoporosis Care

Start date: February 8, 2018
Phase:
Study type: Observational

The St JOSEPH'S HOSPITAL set up a fracture liaison service for osteopotic fracture. A specific nurse screens eligible patient admitted in emergency yard and call them to propose a bone densitometry and a medical coverage.. The aim of the study is to evaluate this new organisation

NCT ID: NCT03451305 Recruiting - Clinical trials for Osteoporosis Fracture

Postrual Reduction With Pillow in Osteoporotic Vertebral Fracture

Start date: January 23, 2018
Phase: N/A
Study type: Interventional

Vertebroplasty in the symptomatic osteoporotic vertebral fracture has become increasingly popular. However, there have been some limitations in restoring the height of the collapsed vertebrae and in preventing the leaking of cement. In the severely collapsed vertebrae of more than two thirds of their original height, vertebroplasty is regarded as a contraindication. We tried postural reduction using a soft pillow under the compressed level. This study was undertaken to investigate the effectiveness of the combination of postural reduction and vertebroplasty for re-expansion and stabilization of the osteoporotic vertebral fractures. single level vertebral compression fracture were treated with postural reduction followed by vertebroplasty. We analyzed the degree of re-expansion according to the onset duration.

NCT ID: NCT03402958 Recruiting - Osteoporosis Clinical Trials

General Practitioner's Place in the Treatment of Fracture Osteoporosis in the Elderly

GEOFRAGE
Start date: January 15, 2018
Phase: N/A
Study type: Observational

Osteoporosis is a major public health problem. Its screening and its treatment remain largely insufficient while therapies have demonstrated their effectiveness. In the event of a severe fracture, the update of the 2016/2017 recommendations, prepared by the Research and Information Group on Osteoporosis and the French Rheumatology Society, concerning osteoporosis recommends a specific treatment with bisphosphonates as first-line treatment, without bone densitometry, regardless of age. The frequency of prescribing anti-osteoporotic treatment as an outpatient after a fracture of the upper extremity of the femur is very low (2% to 21% according to the studies). The main factors associated with non-prescription found are co-morbidities (charlson score> 6), dementia, obesity (BMI> 30), chronic alcoholism, male sex, polypharmacy> 4, age. Conversely, the factors associated with prescribing are recurrent falls (> 2 / year), a history of osteoporotic fracture, an Iso Resource Group> 3, female sex, and corticosteroid therapy.

NCT ID: NCT03178799 Enrolling by invitation - Clinical trials for Osteoporosis Fracture

Randomized Fracture Liaison Services

Start date: June 23, 2017
Phase: N/A
Study type: Interventional

Aims: To compare clinical outcomes for patients under FLS or usual care at the NTUH MH and BB. Method: Four hundred subjects with new hip fracture or newly identified vertebral fracture are randomly assigned into FLS and usual care (UC). FLS subjects received osteoporosis-related assessments, treatments, consultations on diet, medications, exercise, fall preventions given mainly by care managers with followed up telephone call at 4, 8, 12, 18, 24 months then annually for up to 10 years. Physicians manage UC subjects at their own plans without pre-specified protocols as FLS subjects. Care managers will perform baseline assessments and follow them by telephone annually for up to 10 years. Major outcomes include bone mineral density assessment rate, calcium, vitamin D, and osteoporosis medication initiation and adherence rate, fall and fracture incidences, mortality, and healthcare resource utilizations.

NCT ID: NCT03095690 Completed - Clinical trials for Idiopathic Parkinson's Disease

Volumetric Bone Mineral Density and it's Relationship With Osteoporotic Fractures in Parkinson's Disease

DOPPA
Start date: January 7, 2016
Phase: N/A
Study type: Interventional

Idiopathic Parkinson's disease (IPD) is the second most frequent neurodegenerative disease. Its association with osteroporosis and fragility fracture is now clearly demonstrated, but the determinants of this osteoporosis are yet to be explained. Our aim was to study factors associated with volumetric bone mineral density (vBMD) and bone microstructure at the tibia and radius in IPD.

NCT ID: NCT03044015 Recruiting - Clinical trials for Osteoporotic Fractures

Primary Care Based Intervention for the Secondary Prevention of Osteoporotic Fractures

APROP
Start date: January 2017
Phase: N/A
Study type: Interventional

BACKGROUND Recent evidence has been published about the effectiveness for the secondary prevention of osteoporotic fractures (OF) of the hospital-based fracture liaison services. AIM To assess the effectiveness of a primary care based intervention in the secondary prevention of OF. METHODOLOGY Prospective study of random clusters, defined at the primary-care trust (PCT) level. Total study follow-up 3 years. Sample size 1800 patients. DESCRIPTION To launch a defined strategy for the identification of OF. To carry out a primary care based intervention about lifestyle, diet and drug prescription, if needed, with an intensive follow-up in the intervention PCT vs treatment as usual in the control branch. ANALYSIS As the outcome are the new OF, a survival analysis will be done. Risk factors will be analyzed through Cox proportional hazard regression model stratified by age groups. Outcomes : - new OF ratio in intervention vs control areas. - maintenance of the adherence to the pharmacological and non pharmacological interventions proposed - assessment of cost-effectivity of the intervention

NCT ID: NCT02972424 Recruiting - Clinical trials for Osteoporotic Fractures

PTH(1-34) and Pelvic Fracture Healing - a Randomized Controlled Trial

Start date: May 1, 2017
Phase: Phase 2
Study type: Interventional

In the proposed trial the investigators will recruit women and men >65 years of age with acute osteoporosis-related pelvic fractures and address 3 specific aims over 3 months of treatment in a placebo controlled double blind study to determine if standard care and teriparatide 20 mcg/day versus placebo for pelvic fractures: 1. Results in earlier evidence of cortical bridging on routine radiographs followed by confirmatory Focus CT, a novel method to reduce radiation exposure from CT scans (primary outcome). 2. Leads to a faster reduction in pain as assessed by both the Numeric Rating Scale and a reduction in the use of narcotics (secondary outcome). 3. Leads more rapidly to improved functional outcome using a short physical performance battery to assess lower extremity function (secondary outcome).

NCT ID: NCT02924545 Completed - Osteoporosis Clinical Trials

Evaluation of Osteoporosis Support After a Severe Osteoporotic Fracture in Women Over 50 Years in University Hospital

Start date: January 2015
Phase: N/A
Study type: Observational

Evaluate the support of osteoporosis in women over 50 years with severe osteoporotic fractures (hip, vertebral, rib, Humeral, pelvic fractures) in the Nîmes University Hospital taking prediction of treatment of osteoporosis as criterion.

NCT ID: NCT02922478 Recruiting - Heart Failure Clinical Trials

Role of Comorbidities in Chronic Heart Failure Study

RoC-HF
Start date: September 2016
Phase: N/A
Study type: Observational [Patient Registry]

This study aims to create a database of patients with stable and chronic heart failure with comprehensive assessment of bone, skeletal and vascular status. RoC-HF will facilitate cross-sectional and, eventually, longitudinal mechanistic epidemiological analyses to disentangle the role of the bone- vascular axis in chronic heart failure. Blood and urine samples will be stored to facilitate future biomarker analyses.

NCT ID: NCT02803190 Enrolling by invitation - Clinical trials for Osteoporosis Fracture

Osteoporosis and Fall Prevention and Posture Correction Interventions in the Metropolitan Area

Start date: June 2016
Phase: N/A
Study type: Interventional

The investigators' previous studies in 2014 and 2015 have demonstrated that among community-dwelling older adults with high osteoporotic fracture risks. many sarcopenia indices can be improved and bone mineral density (BMD) maintained with different exercise programs. In 2016, the investigators aim to determine the effects of 2 exercise interventions on posture corrections and further improvement of sarcopenic indices