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Opioid-Related Disorders clinical trials

View clinical trials related to Opioid-Related Disorders.

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NCT ID: NCT05352412 Completed - Opioid Use Disorder Clinical Trials

Stigma and a Shared Decision Aid

Start date: April 7, 2022
Phase: N/A
Study type: Interventional

A major barrier for the uptake of evidence-based interventions to address the ongoing opioid epidemic in the US, especially in rural regions, is stigma, which occurs at many levels, including that of the patient and provider. A shared decision making aid is an evidence-based method for increasing engagement and knowledge of both patients and providers, potentially democratizing treatment decisions, especially in stigmatized conditions. The investigators propose to adapt and pilot a decision aid for OUD treatment and harm reduction in two hospitals in rural Missouri to evaluate whether this reduces stigma in both patients and providers.

NCT ID: NCT05327777 Completed - Pain Clinical Trials

Toward Zero Prescribed Opioids for Outpatient General Surgery

Start date: November 1, 2019
Phase: Phase 4
Study type: Interventional

Investigators have created an opioid reduction "package" which includes patient education, non-narcotic pain control instructions, and limited (or no) opioid pain prescriptions provided at discharge in an attempt to reduce the number of opioid consumption after outpatient general surgery.

NCT ID: NCT05325788 Completed - Clinical trials for Alcohol Use Disorder

Developing e-Covery, an App-based Intervention to Support Individuals With Co-occurring Problem Alcohol and Opioid Use

Start date: November 4, 2022
Phase: N/A
Study type: Interventional

This project aims to improve the health of individuals engaged in co-occurring alcohol and opioid use by supporting the maintenance of behavior change initiated in substance use treatment. Building on prior research, this study will entail a stage 1b pilot to test the feasibility and acceptability of an app-based intervention for individuals reporting co-occurring alcohol and opioid use. The intervention will involve modifying an app currently used in a research study to collect GPS information to send push notifications when individuals encounter self-identified place-based triggers. Thirty individuals completing substance use treatment will consent to use the app for a thirty-day pilot period and will complete assessments of intervention feasibility and acceptability. Using within-subject tests, the analysis will summarize participant responses to assessments and will compare the use of general messaging to place-specific messaging.

NCT ID: NCT05269706 Completed - Opioid Use Disorder Clinical Trials

Cannabidiol in the Treatment of Opioid Use Disorder

Start date: May 18, 2022
Phase: Phase 1
Study type: Interventional

The goal of the current study is to evaluate the bioavailability of CBD in normal healthy Individuals. This is an open cross-overdesign study in healthy individuals to assess the safety and pharmacokinetic (PK) effects of cannabidiol.

NCT ID: NCT05262725 Completed - Opioid Use Disorder Clinical Trials

Behavioral Activation for Opioid Use Disorder

Start date: March 30, 2022
Phase: N/A
Study type: Interventional

The overall purpose of this pilot study is to evaluate the feasibility and acceptability of values-based behavioral activation (BA) as an adjunct intervention for patients receiving medications for opioid use disorder (OUD) in primary care. Researcher will evaluate the following aims: 1) examine the feasibility of BA for OUD in primary care, 2) examine whether the BA intervention and study requirements are acceptable to participants, and 3) determine the psychometric properties of the outcome measures in people with OUD. Participants will complete 4-6 brief counseling sessions over the course of 12 weeks. During the first session, participants will discuss values and recovery outcomes important to them. Next, they will set 2-3 personal goals to work on before the next BA session. At the follow-up sessions, participants will update the counselor on progress made or challenges experienced. Personal values will be reviewed and participant goals updated. Study measures (surveys and urine drug tests) will be completed at the start, partway through, and at the end of the intervention.

NCT ID: NCT05252767 Completed - Pain, Postoperative Clinical Trials

Patient Engagement in Perioperative Pain Management Project

Start date: February 1, 2022
Phase: N/A
Study type: Interventional

Previously, the study team evaluated the implementation and effectiveness of the Johns Hopkins Perioperative Pain Program (PPP), which coordinates continuum of care for surgical patients on chronic opioid therapy throughout the perioperative period. Based on the findings of that project, the study team developed an educational intervention intended to improve patient engagement in perioperative pain management. In this project, the study team will formally implement a randomized controlled trial to evaluate the effectiveness of the intervention developed.

NCT ID: NCT05233085 Completed - Clinical trials for Opioid Use Disorder (OUD)

A Safety Study of AZD4041 in Healthy Participants

Start date: December 17, 2021
Phase: Phase 1
Study type: Interventional

This is a Phase 1, single-centre, randomized, double-blind, placebo-controlled, multiple ascending doses (MAD) study in healthy male and female adult participants. The study will include up to 48 participants (12 participants per cohort) who will be randomized 9:3 to active drug or placebo. Each cohort will receive AZD4041 or placebo in a MAD study. A sequential cohort MAD design will be employed to assure that higher doses are administered to healthy participants only after lower doses have demonstrated an acceptable safety profile. The total study duration will be up to 59 days (including Screening) per participant.

NCT ID: NCT05221866 Completed - Opioid Use Clinical Trials

Efficiency And Quality In Post-Surgical Pain Therapy After Discharge

EQUIPPED
Start date: March 14, 2022
Phase: N/A
Study type: Interventional

Following inpatient surgery, more than 80% of patients are prescribed opioids for use after discharge, yet up to 90% of patients report leftover opioids, and only 16% maximize non-opioid therapy. The proposed research seeks to test a provider-facing decision support tool and a patient-facing smartphone app to reduce the amounts of opioids prescribed and taken following discharge, while ensuring effective treatment of pain after surgery.

NCT ID: NCT05209191 Completed - Clinical trials for Prescription Opioid Misuse

Reducing High School Athletes' Prescription Opioids Misuse and Diversion Through the Student Athlete Wellness Portal

Start date: April 24, 2020
Phase: N/A
Study type: Interventional

The goal of this study is to prevent prescription opioid misuse among high school athletes by developing, demonstrating the feasibility, and evaluating the outcomes of an innovative digital intervention.

NCT ID: NCT05184907 Completed - Opioid Use Disorder Clinical Trials

Effects of RME on Engagement in Buprenorphine Treatment

Start date: May 1, 2022
Phase: N/A
Study type: Interventional

The investigators will conduct a Randomized Controlled Trial (RCT) comparing the Remote Motivational Enhancement (RME) coaching sessions + MindWell screenings arm to an Information-only + MindWell screenings arm on early engagement in treatment support services, as measured by overall action plan initiation.