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Alcohol Use Disorder clinical trials

View clinical trials related to Alcohol Use Disorder.

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NCT ID: NCT03530384 Not yet recruiting - Clinical trials for Alcohol Use Disorder

Training Inhibition in Alcohol Use Disorder

Start date: June 30, 2018
Phase: N/A
Study type: Interventional

More and more studies aim to improve neurocognitive functioning in alcohol use disorder, but very few studies have focused on training-inhibitory-control efficacy on alcohol intake. Our program relies on a comprehensive model of addiction considering inhibition deficit as the hallmark of addiction. Our program proposes inhibition training on a task which does not refer to alcohol, combined with a debriefing promoting transferability of the enhanced skill and psychoeducation. In this perspective of aiming to retrain deficits involved in addiction in itself and not only due to alcohol toxicity. We propose an add-on single-blinded randomized controlled trial, in alcohol use disorder, assessing the efficacy of a computerized cognitive training program targeting inhibition as compared to treatment as usual.

NCT ID: NCT03524599 Not yet recruiting - Clinical trials for Alcohol Use Disorder

Scale-up of Prevention and Management of Alcohol Use Disorders and Comorbid Depression in Latin America

Start date: June 1, 2018
Phase: N/A
Study type: Interventional

A quasi-experimental study will compare primary health care-based prevention and management of alcohol use disorder, operationalized by heavy drinking, in three intervention cities from Colombia, Mexico and Peru with three comparator cities from the same countries. In the implementation cities, primary health care units (PHCUs) will receive training embedded within ongoing supportive municipal action over an 18-month implementation period. In the comparator cities, practice as usual will continue at both municipal and PHCU levels. The primary outcome will be the proportion of consulting adult patients intervened with (screened and advice given to screen positives).

NCT ID: NCT03517878 Active, not recruiting - HIV Infections Clinical Trials

Evaluation of a Home-based Community Health Worker Program in Rural Eastern Cape, South Africa

Start date: August 11, 2014
Study type: Observational

The purpose of this early Phase 2 comparison trial is to evaluate the impact of community health worker (CHW) home visitors on pregnant women and their children in a rural setting in the rural Eastern Cape of South Africa. The intervention provided by the CHWs targets underweight children, mothers living with HIV (MLH), mothers using alcohol, and depressed mothers with the goal of supporting pregnant women to improve birth outcomes, decrease the number of children born with a low birthweight, and develop child caretaking skills over time. UCLA has identified and matched four areas surrounding primary health care clinics: two intervention areas in which this CHW program has been running for one year, and two control areas without the program. Mothers in the research area are followed for one year after giving birth.

NCT ID: NCT03507075 Completed - Clinical trials for Alcohol Use Disorder

Remote Alcohol Monitoring to Facilitate Abstinence Reinforcement: Feasibility

Start date: November 15, 2014
Phase: Phase 1/Phase 2
Study type: Interventional

Directly reinforcing abstinence from alcohol with monetary incentives is an effective treatment for alcohol dependence, but barriers in obtaining frequent, verified biochemical measures of abstinence limit the dissemination of this treatment approach. The goal of this feasibility study is to determine if using technological advancements to remotely, accurately, and securely monitor alcohol use with a newly developed breathalyzer is an effective treatment that is acceptable to participants. If validated, this treatment approach has the potential to facilitate the dissemination of an effective, evidence-based treatment for alcohol dependence to a broader population whose treatment needs are not currently being adequately met.

NCT ID: NCT03489850 Not yet recruiting - Clinical trials for Alcohol Use Disorder

Ibudilast and Withdrawal-Related Dysphoria

Start date: June 2018
Phase: Phase 2
Study type: Interventional

Alcohol use disorder (AUD) is a prevalent and disabling psychiatric disorder with few, and only moderately efficacious, treatment options. Consequently, the identification of novel treatment targets and the development of rigorous laboratory paradigms to screen and optimize novel therapeutics represents a research priority. Ibudilast (IBUD) is a neuroimmune modulator that inhibits phosphodiesterase-4 and -10 and macrophage migration inhibitory factor. Recently in an AUD sample, IBUD was shown to decrease reactivity to a psychological stressor. Furthermore, IBUD was effective in blunting alcohol reward among participants with greater depressive symptoms, a hallmark symptom of protracted withdrawal. Recently, preclinical research in opiates has demonstrated that drug withdrawal is necessary for microglia activation and neuroinflammation in reward networks, suggesting that IBUD may be most effective among patients who experience withdrawal-related dysphoria. Therefore, this proposed study aims to examine withdrawal-related dysphoria as a moderator of IBUD efficacy in the natural environment measured using Daily Diary Assessment (DDA) approaches. To accomplish this aim, participants meeting criteria for AUD and balanced on the presence of withdrawal-related dysphoria will be enrolled in a double-blinded IBUD trial including consisting of two weeks randomized to medication and DDA assessment. The proposed research aims are: Aim 1: Test whether IBUD reduces basal negative affect in abstinence, and blunts alcohol-related negative reinforcement. It is hypothesized that IBUD will reduce basal levels of negative affect during alcohol abstinence, and in so doing will interfere with alcohol-induced blunting of negative affectivity as captured during naturalistic drinking episodes. Aim 2: Test whether IBUD attenuates neural alcohol cue-reactivity. It is hypothesized that IBUD will reduce BOLD activation to alcohol cues in mesocorticolimbic reward circuitry. Aim 3: Test whether withdrawal-related dysphoria moderates the effects of IBUD. It is hypothesized that IBUD will alleviate basal negative affect, interfere with alcohol-induced negative reinforcement and attenuate BOLD activation to alcohol cues only among participants who experience dysphoria in withdrawal. Aim 4: Test whether neural activation to alcohol cues is predictive of drinking outcomes. It is hypothesized that individuals with higher mesocorticolimbic activation to alcohol cues will report more drinking in the week following the neuroimaging session.

NCT ID: NCT03474588 Not yet recruiting - Clinical trials for Alcohol Use Disorder

CBT4CBT With Spanish Alcohol Users

Start date: January 2019
Phase: N/A
Study type: Interventional

Specific aims are as follows: - To adapt our existing CBT4CBT program for use with Spanish-speaking alcohol users in a web-based platform - To conduct an 8-week randomized trial evaluating the feasibility and efficacy of adding CBT4CBT-Spanish to treatment as usual in a community based treatment program in a population of 90 Spanish-speaking individuals who meet current criteria for alcohol use disorder - To evaluate the long-term durability and/or delayed emergence of treatment effects through a six month follow-up after termination of the study treatments. Given previous evidence regarding the durability of standard clinician-delivered CBT and computer-assisted CBT4CBT, we hypothesize that CBT4CBTSpanish will be significantly more effective than standard treatment alone through the follow-up.

NCT ID: NCT03467191 Recruiting - Alcoholism Clinical Trials

Behavioral Alcohol Responses (BAR) Study

Start date: February 13, 2018
Phase: Early Phase 1
Study type: Interventional

This study aims to identify risk factors that prospectively predict alcohol problems in young adults.

NCT ID: NCT03457077 Recruiting - Clinical trials for Alcohol Use Disorder

Neural and Mobile Assessment OF Behavior Change Among Problem Drinkers

Start date: February 27, 2018
Phase: N/A
Study type: Interventional

This study will examine the neural mechanisms underlying both spontaneous behavior change and behavior change in response to a brief intervention among problem drinkers.

NCT ID: NCT03449095 Recruiting - Alcoholism Clinical Trials

Understanding Alcohol Reward in Social Context

Start date: November 4, 2017
Phase: N/A
Study type: Interventional

In this study, the investigators examine whether emotional and social reward from alcohol varies depending on the social context of consumption.

NCT ID: NCT03448016 Recruiting - Clinical trials for Alcohol Use Disorder

[C-11]NOP-1A and Alcohol Use Disorder

Start date: May 27, 2016
Phase: Early Phase 1
Study type: Interventional

The goal of this study is to compare [C-11]NOP-1A binding in recently abstinent alcohol use disorders and controls