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Alcohol Use Disorder clinical trials

View clinical trials related to Alcohol Use Disorder.

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NCT ID: NCT03707951 Not yet recruiting - Clinical trials for Alcohol Use Disorder

N-Acetylcysteine for Adolescent Alcohol Use Disorder

Start date: January 2019
Phase: Phase 2
Study type: Interventional

This is a 8-week randomized, placebo-controlled trial testing the effects of N-acetylcysteine (NAC), on a platform of weekly evidence-based brief alcohol intervention for 120 adolescents with alcohol use disorder (AUD). The primary efficacy endpoint is reduction in alcohol use (total standard drinks), compared between NAC and placebo groups.

NCT ID: NCT03701204 Not yet recruiting - Clinical trials for Alcohol Use Disorder

Contingency Management for Alcohol Use Disorder

Start date: October 8, 2018
Phase: N/A
Study type: Interventional

Randomized pilot study of a device (smartphone app) that poses non-significant risk to participants and is exempt from Investigational Device Exemption regulations [21 Code of Federal Regulations 812.2(c)

NCT ID: NCT03696888 Not yet recruiting - Alcohol Dependence Clinical Trials

Skills-training for Reducing Risky Alcohol Use in App Form

Start date: November 1, 2018
Phase: N/A
Study type: Interventional

This study evaluates the efficacy of a skills training web-based mobile phone application, Telecoach among individuals in the general population seeking help for their risky alcohol consumption on the Internet. The design is a two-armed randomized controlled design, and outcomes are measured in terms of changes in excessive alcohol use at follow up 6, 12 and 26 weeks after study initiation and baseline data gathering. The Telecoach web app delivers skills training in the form of exercises commonly used in psychosocial interventions for risky alcohol use. The controll condition is a web app providing information on the effects of alcohol on the consumers' health.

NCT ID: NCT03684798 Recruiting - Clinical trials for Alcohol Use Disorder

MCII for Alcohol Use Disorders

Start date: August 14, 2018
Phase: N/A
Study type: Interventional

Mental Contrasting (MC) consists of imaging a desired future and comparing it with obstacles of the present reality in order to increase goal commitment when expectations of success are high. The study aims to investigate the effects of a motivational training (Mental Contrasting with Implementation Interventions; MCII) as a therapeutic add-on to standard treatment in inpatients with Alcohol Use Disorders.

NCT ID: NCT03662737 Not yet recruiting - Healthy Clinical Trials

VRT as a Biomarker of Cerebellar Dysfunction in Chronic Cannabis Use

Start date: September 2018
Study type: Observational

Chronic cannabis consumption has been associated with poor psychosocial functioning that could be associated to cerebellar dysfunction. The cerebellum has a relevant role in adaptation processes and has a high density of cannabinoid 1 receptor (CB1R). Implicit motor learning is a cerebellum dependent function that can be measured with a visuomotor rotation task (VRT). The project aims to identify a sensitive and specific biomarker of cerebellum dysfunction in chronic cannabis users. The investigators would like to demonstrate that the visuomotor rotation paradigm is valid to measure and quantify such a dysfunction. A longitudinal prospective study with a 3 month follow-up is proposed. 3 groups will be included: 1) chronic cannabis users; 2) individuals with an alcohol use disorder; and 3) healthy controls. All groups will be matched by sex and age. Forty individuals will be included in each group. Individuals will be assessed at baseline, at first month and at 3-months of follow-up. Sociodemographic and clinical data will be recorded. Information on cannabis consumption will be registered using an App. Participants will do the visuomotor rotation task and answer three questionnaires: the Intrinsic Motivation Inventory, the Scale for the assessment and rating of ataxia (SARA) and the Harris tests for lateral dominance. The biomarker developed by this project will facilitate the detection of cerebellar alterations in chronic cannabis users, and will permit to quantify and monitor such alteration over time. The team's intention is to patent the proposed model and disseminate it in order to use it in clinical practice at both primary and specialized health centres.

NCT ID: NCT03661853 Recruiting - Clinical trials for Alcohol Use Disorder

Effect of CBT Microinterventions on Mechanisms of Behavior Change Among Adults With AUD

Start date: August 8, 2018
Phase: N/A
Study type: Interventional

This proposed R21, Effect of CBT Microinterventions on Mechanisms of Behavior Change among Adults with AUD: Using Eye Tracking to Measure Pre-Post Cognitive Control, uses a translational team science approach to isolate and examine the effect of three different Cognitive Behavioral Therapy (CBT) interventions (functional analysis (FA), cognitive restructuring for alcohol related thoughts (CR), and dealing with cravings (DC)) on specific hypothesized mechanisms (cognitive control, stimulus salience, or craving/arousal, respectively).

NCT ID: NCT03660124 Recruiting - Clinical trials for Alcohol Use Disorder

Deep Brain Stimulation (DBS) for the Treatment of Refractory Alcohol Use Disorder (AUD): Pilot Trial

Start date: May 25, 2018
Phase: N/A
Study type: Interventional

This is a phase I, non-blinded, non-randomized, pilot trial for safety and efficacy of DBS for AUD. Patients who meet inclusion and exclusion criteria will be identified and recruited from the practices of Sunnybrook psychiatrists. Five (5) subjects will be enrolled and study duration for each patient will be of one (1) year. Our primary objective is to establish the safety of DBS in a patient population with treatment refractory AUD. In addition to demonstrating safety, our second primary objective will be to evaluate if DBS-targeted nucleus accumbens in alcoholism is efficacious in the treatment-refractory patients with AUD. This will be measured by various outcome measures that will include validated scales to assess addiction and craving behaviours.

NCT ID: NCT03658330 Completed - Clinical trials for Major Depressive Disorder

Naltrexone Plus Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder

Start date: May 2016
Phase: Phase 2
Study type: Interventional

To evaluate if naltrexone plus ketamine is effective in reducing depression and alcohol consumption.

NCT ID: NCT03652675 Not yet recruiting - Hepatitis C Clinical Trials

Understanding and Intervening With Heavy Drinking Among Patients With HIV and HCV

Start date: September 2018
Phase: N/A
Study type: Interventional

Among patients with HIV, especially those also infected with HCV, heavy drinking is associated with significant risks to health. However, little is known about how to best intervene with co-infected heavy drinkers, a particularly high risk group for whom targeted intervention has not been developed. Therefore, this study proposes to test a newly developed drinking-reduction intervention for patients with both HIV and HCV, which combines components of successful interventions developed for HIV and for liver disease patients. 60 HIV/HCV co-infected drinkers from HIV primary care will be recruited in order to ensure an adequate final sample size of 45 participants completing the study. A clinic recruiter will identify and refer potential participants based on their medical record, who will then be screened for eligibility by the research coordinator. Participants will be randomly assigned to an intervention or control condition, while ensuring that equal numbers of individuals with alcohol use disorder are assigned to each condition. The intervention condition will receive brief in-person sessions with a counselor and will be asked to use a smartphone app daily to keep track of drinking and other health behaviors for two months. The intervention sessions will include information about HIV, HCV and alcohol, and the counselor will give the participant information about their liver function and alcohol use to try to motivate them to drink less. The control condition will simply be asked to drink less and will be given pamphlets with general information on HIV, Hepatitis C, and drinking from educational websites on HIV/HCV co-infection. The intervention condition will then be evaluated to see if it was more effective at reducing drinking than the control condition.

NCT ID: NCT03645408 Not yet recruiting - Clinical trials for Alcohol Use Disorder

The Effects of Exenatide, a GLP-1 Agonist, on Alcohol Self-Administration in Heavy Drinkers

Start date: February 2019
Phase: Phase 1
Study type: Interventional

A double-blind, randomized, placebo-controlled, crossover design trial will be used to test the effect of exenatide on alcohol self-administration and craving following a priming dose of alcohol. The specific objective of this research is to determine whether exenatide has effects on alcohol consumption.