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Alcohol Use Disorder clinical trials

View clinical trials related to Alcohol Use Disorder.

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NCT ID: NCT03829761 Not yet recruiting - Clinical trials for Alcohol Use Disorder

Cerebellar Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Alcohol Use Disorder

Start date: February 20, 2019
Phase: N/A
Study type: Interventional

The objective of the current study is to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) on self-reported negative affect, cerebellar brain activation and alcohol use outcomes in alcohol use disorder (AUD).

NCT ID: NCT03827460 Not yet recruiting - Clinical trials for Alcohol Use Disorder

Sex Differences in the Response to Abstinence From Alcohol.

SPAR
Start date: February 25, 2019
Phase: N/A
Study type: Interventional

In laboratory animals, repeated cycles of abstinence from and return to alcohol drinking can lead to changes in alcohol intake. In a study of the effect of abstinence on drinking in humans, the investigators found evidence that abstinence affects drinking differently in women compared to men. In the present study, the investigators propose to study how men and women respond to abstinence, and whether this information can be used to improve intervention and prevention strategies.

NCT ID: NCT03823599 Not yet recruiting - Clinical trials for Alcohol Use Disorder

Alcohol Brief Intervention Plus Personalized Mobile Chat-based Intervention to Reduce Alcohol Misuse in an Emergency Department

Start date: February 1, 2019
Phase: N/A
Study type: Interventional

This project focuses on patients in AED. Objectives of this project are: 1. To examine the factors associated with alcohol drinking and alcohol use disorder 2. To examine the effect of face-to-face alcohol brief intervention on drinking reduction 3. To examine the effect of a continuous interactive chat-based intervention via "WhatsApp" on drinking reduction 4. To explore the perception of face-to-face alcohol brief intervention 5. To explore the perception of continuous interactive chat-based intervention via instant messaging mobile application "WhatsApp"

NCT ID: NCT03818971 Not yet recruiting - Clinical trials for Alcohol Use Disorder

Study of Retinal Function Using Electroretinogram in Regular Alcohol Users

ERICA
Start date: February 4, 2019
Phase: N/A
Study type: Interventional

Alcohol is a major public health problem and its neurotoxic effects are, among other things, responsible for altering the functioning of cerebral neurotransmission pathways. The retina is an anatomical and developmental extension of the central nervous system. It is composed of several layers of retinal neurons that share similar anatomical and functional properties with brain neurons. Retinal neurons are notably equipped with a complex system of neurotransmission constituted by the main neurotransmitters that are involved in the central effects of alcohol: glutamate, dopamine, serotonin ... The retina is used here as a site of indirect investigation for abnormal central neurotransmission pathways following regular alcohol use. It is recognized to date as a good site for investigating central abnormalities in neuropsychiatric and addictive disorders. The objective of this project is to study the retinal function using electroretinogram (ERG) in regular alcohol users to isolate potential markers of cerebral neurotransmission abnormalities.

NCT ID: NCT03818191 Not yet recruiting - Clinical trials for Alcohol Use Disorder

Pharmacogenomics and Pharmacometabolomics of Acamprosate Treatment Outcome

Start date: April 1, 2019
Phase: Phase 4
Study type: Interventional

AUDs are difficult to treat, and relapse rates are high, with an estimated 80% of individuals with AUDs returning to alcohol use after completing addictions treatment. Novel treatment approaches are needed to enhance long term sobriety. The investigator's research team has been investigating the use of acamprosate to prevent relapse to alcohol use. Unfortunately despite being FDA approved and endorsed by the American Psychiatric Association only 10% of patients treated for AUD are prescribed acamprosate or other antidipsotropic medications. The number is higher for patients treated in programs affiliated with Mayo Clinic Addiction Services (approximately 20%) but is way less than expected. The most common reasons behind these low numbers are the understanding that not every patient benefits from the use of specific medication and the lack of biomarkers predictive of response. The purpose of this project is to identify such biomarkers by discovery of genomic and metabolomic markers associated with response to acamprosate treatment.

NCT ID: NCT03816527 Recruiting - Clinical trials for Alcohol Use Disorder

Selective Attention in Alcohol Use Disorder

Start date: January 1, 2019
Phase:
Study type: Observational

This study examines the selective attention to emotional- and alcohol- associated cues in alcohol- dependant and healthy participants.

NCT ID: NCT03810950 Recruiting - Clinical trials for Alcohol Use Disorder

Psychobiology of Stress and Alcohol Craving

Start date: January 1, 2019
Phase: N/A
Study type: Interventional

In this feasibility study the investigators are using a setup of stress-related body sensors including established as well as innovative sensor-based measures to identify predictor profiles for alcohol-related behavioral and neural measures in Alcohol Use Disorder (AUD). Long-term aim is the definition of a setup of mobile sensors and their integration in a mobile infrastructure that allows the prediction of stress related alcohol intake in an ambulatory setting.

NCT ID: NCT03810924 Not yet recruiting - Clinical trials for Alcohol Use Disorder

Stress-related Predictor Profiles in Human Addiction

Start date: July 1, 2019
Phase: N/A
Study type: Interventional

Long-term aim is the definition of a setup of mobile sensors and their integration in a mobile infrastructure that allows the prediction of stress related alcohol intake in an ambulatory setting. Here, we aim to identify stress- and alcohol cue-related physiological markers in a lab experiment to assess interactions between acute psychological vs. physical stress exposure and alcohol cue-exposure regarding their effects on measures relevant for the development and maintenance of Alcohol Use Disorder (AUD). Further, we aim to identify neural correlates in brain circuits of motivational, cognitive, and affective processing. In addition to applying established stress-related markers, we will integrate innovative sensor-based measures.

NCT ID: NCT03809286 Recruiting - Clinical trials for Alcohol Use Disorder

The Effect of rTMS to the Prefrontal Cortex in Alcohol Use Disorder

MAGNA
Start date: January 2019
Phase: N/A
Study type: Interventional

The goal of this study is to investigate a treatment approach for alcohol use disorder (AUD) using a novel form of brain stimulation called deep repetitive transcranial magnetic stimulation (rTMS). The investigators will be targeting frontal regions of the brain that are important for memory and decision making. These brain regions have been shown to be impaired in patients with AUD. Previous studies have mostly used rTMS to a different frontal brain region that is not as deep. These studies have shown that rTMS can reduce craving for alcohol, but there is a lack of research showing that rTMS impacts alcohol consumption.

NCT ID: NCT03807544 Recruiting - Clinical trials for Alcohol Use Disorder

Treatment Parameters for the Empower Neuromodulation System (ENS)

AUD Aim 1
Start date: January 15, 2019
Phase: N/A
Study type: Interventional

The subject will be administered a treatment at a treatment location and then be asked if he/she believes it is the active treatment, sham treatment, or does not know. A clinical-grade nerve conduction assessment system will be used both to provide electrical stimulation at four locations to record peripheral responses. The subject will self-administer two treatment sessions at two active treatment sites.