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Alcohol Use Disorder clinical trials

View clinical trials related to Alcohol Use Disorder.

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NCT ID: NCT03765476 Recruiting - Clinical trials for Alcohol Use Disorder

Validation of a Training Program for Patients With Alcohol Use Disorder

Start date: July 1, 2018
Phase: N/A
Study type: Interventional

This study aims to detect how the Web-based program SALIENCE affects patients with alcohol-use Disorder in terms of craving, cognitive functions and risk of relapse.

NCT ID: NCT03764098 Not yet recruiting - Clinical trials for Alcohol Use Disorder

Mechanistic Evaluation of Guanfacine on Drinking Behavior

Start date: January 1, 2019
Phase: Phase 2
Study type: Interventional

For this protocol, the investigators plan to collect pilot data to examine sex differences in guanfacine's effect on 1) counteracting stress and stimulation based drinking behavior in the laboratory and 2) improving clinical outcomes during a subsequent treatment phase.

NCT ID: NCT03758274 Not yet recruiting - Alcohol Abuse Clinical Trials

Talk Therapy by Phone to Promote Treatment for Alcohol Problems

Start date: December 17, 2018
Phase: N/A
Study type: Interventional

A small percentage of individuals with alcohol use disorder (AUD) obtain alcohol-related care despite research showing that treatment is effective. This randomized controlled trial tests the efficacy of a brief, phone based cognitive behavioral intervention to increase treatment engagement, improve alcohol related outcomes, and show that treatment engagement is a mechanism for the improved outcomes in individuals with AUD.

NCT ID: NCT03758053 Not yet recruiting - Clinical trials for Alcohol Use Disorder

Adverse Childhood Experiences in Substance-related Disorders

Start date: December 15, 2018
Study type: Observational

Aversive childhood experiences (ACE) and their relation to the development of an alcohol use disorder will be measured with fMRI.

NCT ID: NCT03747055 Recruiting - Depression Clinical Trials

Effectiveness of Group Focused Psychosocial Support for Adults Affected by Humanitarian Crises

Start date: November 25, 2018
Phase: N/A
Study type: Interventional

This is an effectiveness study of group problem management plus, a low-intensity psychological intervention, delivered in five sessions to adults affected by humanitarian crises. The current study will evaluate the effectiveness of Group Problem Management Plus (PM+).

NCT ID: NCT03746808 Recruiting - Clinical trials for Alcohol Use Disorder

Development and Testing of a Just-in-Time Adaptive Smart Phone Intervention to Reduce Drinking Among Homeless Adults

Start date: November 19, 2018
Phase: N/A
Study type: Interventional

Homeless adults are 8 times as likely to be alcohol dependent compared with adults in the general population, yet few studies have examined the precipitants of alcohol use in this vulnerable population. Ecological momentary assessments (EMAs) that involve repeated assessment of thoughts/mood/behaviors (e.g., via smart phone) is currently the most accurate way to assess individuals in real-time in their natural environments. Advances in smartphone technology also allow for the collection of continuous geolocation and other passive sensing data. Thus, researchers can now link environmental risks and protective factors to outcomes, without reliance on subjective reporting alone. Building on prior work, this study will use a three-phase study to develop and test a "just in time" adaptive intervention to reduce alcohol use in homeless men and women. Phase I will use smartphones and passive sensing technologies to monitor geolocation, psychosocial variables (e.g., stress, affect, urge to drink), and alcohol use in a group of 80 homeless adults enrolled in shelter-based substance abuse treatment. Phase I will identify environmental (i.e., geolocation), cognitive, and behavioral antecedents of alcohol use over 4 weeks. Phase II will use this information to create a risk algorithm and tailored treatment messages that anticipate and intervene to prevent drinking. The resulting app will assess imminent risk of alcohol use after each EMA and will deliver relevant treatment messages that match a person's current risk factors. Phase III will test the feasibility, acceptability and preliminary efficacy of the app in a sample of 40 homeless adults enrolled in shelter-based treatment who receive the EMA plus treatment messages over 4 weeks. Drinking will be determined via self-report, supplemented by a transdermal alcohol sensor (i.e., SCRAM) worn by participants. This project will be the first to combine geolocation and psychosocial variables to identify real-time antecedents of drinking. If effective, this smartphone app could significantly improve treatment engagement, drinking outcomes, and quality of life among homeless adults with alcohol use disorders.

NCT ID: NCT03746366 Recruiting - Clinical trials for Alcohol Use Disorder

[C-11]PiB PET Imaging in Alcohol Use Disorders

Start date: December 1, 2018
Phase: Early Phase 1
Study type: Interventional

To determine whether alcoholics (AUD) have a greater rate of amyloid positivity (ABeta+) compared to an age-matched cognitively normal control group (HC).

NCT ID: NCT03732248 Recruiting - Alcohol Dependence Clinical Trials

Altering Memories That Increase Risk of Relapse in Alcohol Use Disorders

Start date: July 12, 2018
Phase: Phase 1
Study type: Interventional

The purpose of this study is to examine the effects of rapamycin (sirolimus) versus a placebo, an inactive substance, on responses to alcohol cues in individuals with alcohol use disorder. Rapamycin (sirolimus) is a FDA-approved antibiotic and immunosuppressive drug that is currently used to (a) prevent organ transplant recipients from rejecting their transplants (b) treat cardiovascular diseases, and (c) treat some forms of cancer. Rapamycin (sirolimus) is not FDA-approved to treat alcohol use disorder. The use of rapamycin (sirolimus) in this study is investigational, meaning that the study medication is not a proven treatment for alcohol use disorder. The study will examine the medication's use as a potential treatment for alcohol use disorder, as well as how safe and tolerable it is to take.

NCT ID: NCT03709043 Not yet recruiting - Clinical trials for Alcohol Use Disorder

Addressing Heavy Alcohol Use Consumption With Kudzu

Start date: April 2019
Phase: Phase 2
Study type: Interventional

Drinking multiple alcoholic drinks on a single occasion (binge drinking), has many negative health risks but interventions to address this behavior remain limited. This double-blind, placebo-controlled randomized clinical trial will test whether kudzu, an herbal supplement, can reduce heavy alcohol use and alcohol-associated sexual behaviors among sexually-active, binge-drinking individuals at high risk for HIV infection.

NCT ID: NCT03707951 Not yet recruiting - Clinical trials for Alcohol Use Disorder

N-Acetylcysteine for Adolescent Alcohol Use Disorder

Start date: January 2019
Phase: Phase 2
Study type: Interventional

This is a 8-week randomized, placebo-controlled trial testing the effects of N-acetylcysteine (NAC), on a platform of weekly evidence-based brief alcohol intervention for 120 adolescents with alcohol use disorder (AUD). The primary efficacy endpoint is reduction in alcohol use (total standard drinks), compared between NAC and placebo groups.