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Immunometabolism in Pediatric Obesity — IPO  

Obesity Clinical Trial

Official title:
Immunometabolism in Pediatric Obesity

Clinical Trial Summary

This is a study to learn about obesity and how insulin resistance and Type 2 Diabetes develops in children.

Clinical Trial Description

The main purpose of this proposed study is to determine whether the immunometabolic phenotypes of CD4+T cells from obese children is skewed towards Teff with mTOR-driven glycolysis and away from Tregs with AMPK-driven OXPHOS and whether metformin can reverse the immunometabolic phenotypes. This study consists of: 1. An observational cross sectional immune and metabolic analysis of several groups of children including lean, overweight/obese, and T2D. 2. A prospective immune and metabolic analysis of newly diagnosed children with T2D or insulin resistance who will be or were recently prescribed metformin as part of their clinical care. Children with T2D or insulin resistance who will be or were recently prescribed metformin, will be asked to complete two study visits. If completed, the second visit will occur 6 months (+/- 2 weeks) after beginning metformin as part of their clinical care. All other children, will be asked to complete only the first visit. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03960333
Study type Observational
Source Arkansas Children's Hospital Research Institute
Contact
Status Active, not recruiting
Phase
Start date April 25, 2019
Completion date December 31, 2024
View Details
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