Obesity Clinical Trial
Official title:
Longitudinal Observational Study of Human Adipose Tissue (LOSHAT)
The investigators will study the influence of initial fat cell size/number and adipose function (in particular lipolysis) on weight development over very long time periods (years). By comparing investigations of fat biopsies or blood samples obtained at baseline, the investigators will determine the association between adipose morphology/function and changes in weight or development of metabolic complications (e.g. metabolic syndrome, glucose intolerance, type 2 diabetes, dyslipidemia and hypertension).
The investigators will ask all subjects that have previously been examined at the
investigators laboratory (from 1992 and forward) in studies of adipose tissue function if
they are interested to participate in a new study.
Previously obtained results from examinations of adipose tissue, anthropometric measurements
and blood samples will be used as baseline. In addition, saved blood samples and samples from
old fat biopsies can be re-investigated in some cases.
The new investigation includes a questionnaire that the subjects can answer by mail or email.
In addition, anthropometric measurements and blood pressure determination will be performed
at a primary health care center and blood samples will be collected for analysis of fasting
glucose, HbA1C and lipids.
Information regarding all previously investigated subjects will also be collected from
several Swedish national patient registries such as the Patient Register, Prescribed Drug
register and Cause-of Death register.
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