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Liraglutide for HIV-associated Neurocognitive Disorder

Obesity Clinical Trial

Official title:
Effects of Liraglutide on Cognition, Chronic Inflammation and Glycemic Control in Overweight and Obese, HIV-infected Subjects With Type 2 Diabetes.

Clinical Trial Summary

This study will test the effect of liraglutide on cognitive function in HIV-infected overweight or obese subjects with type 2 diabetes.

Clinical Trial Description

HIV, insulin resistance and type 2 diabetes mellitus (DM) are independently associated with cognitive impairment. Considering the synergistic effects of HIV and DM on cognition, these subjects are at increased risk of cognitive impairment. glucagon-like peptide 1 (GLP-1) receptors have wide tissue distribution including the central nervous system. The study hypothesis is that GLP-1 could potentially ameliorate the impairments in cognition in this population. This study will assess the impact of liraglutide on neurocognitive performance and peripheral inflammatory markers. It will also evaluate the effects of liraglutide on glycemic control and metabolic risk factors in HIV infected subjects with type 2 diabetes. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02743598
Study type Interventional
Source Temple University
Contact
Status Terminated
Phase Phase 4
Start date September 2016
Completion date September 2018
View Details
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