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NCT00657436 Clinical Trial

Myeloid-Related Protein in Evaluation of Acute Chest Pain in the Emergency Departement

Myocardial Infarction Clinical Trial

— MyRiAD  

Official title:
Study of Myeloid-related Protein 8/14 and Additional Biomarkers (Multi Marker Approach) for Early Diagnosis and Risk Stratification in Patients Presenting With Acute Chest Pain at the Emergency Department

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00657436
Other study ID # MyRiAD
Secondary ID
Status Completed
Phase N/A
First received April 8, 2008
Last updated May 30, 2012
Start date March 2008
Est. completion date December 2010

Study information
Verified date May 2012
Source University of Zurich
Contact n/a
Is FDA regulated No
Health authority Switzerland: Federal Office of Public Health
Study type Observational

Clinical Trial Summary

The purpose of the study is the evaluation of multiple biomarkers related to acute coronary syndromes, including myeloid-related protein 8/14 (MRP 8/14), along with established clinical markers, for early diagnosis and risk stratification in patients presenting with acute chest pain at the emergency department.

Study hypothesis: MRP 8/14, alone or together with other established or new biomarkers, increases the earliness, sensitivity, and specificity of diagnosing acute coronary syndromes.

Recruitment information / eligibility
Status Completed
Enrollment 403
Est. completion date December 2010
Est. primary completion date December 2010
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 90 Years
Eligibility Inclusion Criteria:

- All patients in the emergency department of the University Hospital Zurich with measurement of troponin during the routine diagnostic evaluation.

Exclusion Criteria:

- Refusal or inability to give informed consent.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
Switzerland Cardiology, University Hospital Zurich

Sponsors (2)
Lead Sponsor Collaborator
University of Zurich Swiss National Science Foundation

Country where clinical trial is conducted

Switzerland, 

References & Publications (1)

Altwegg LA, Neidhart M, Hersberger M, Müller S, Eberli FR, Corti R, Roffi M, Sütsch G, Gay S, von Eckardstein A, Wischnewsky MB, Lüscher TF, Maier W. Myeloid-related protein 8/14 complex is released by monocytes and granulocytes at the site of coronary occlusion: a novel, early, and sensitive marker of acute coronary syndromes. Eur Heart J. 2007 Apr;28(8):941-8. Epub 2007 Mar 26. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Diagnosis of acute coronary syndrome Emergency room and/or hospital stay No
Secondary Incidence of any acute coronary event 1 year No
Secondary Morbidity from coronary artery disease 1 year No
Secondary Mortality 1 year Yes
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