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Accelerated iTBS for Depression and Suicidality — RAPID  

Major Depressive Disorder Clinical Trial

Official title:
Radical aiTBS Protocol for Intractable Depression

Clinical Trial Summary

The overall objective of this current study is to evaluate the feasibility, safety, and tolerability of "high dose" aiTBS in psychiatric inpatient and outpatients with treatment-refractory unipolar, non-psychotic major depressive disorder, using patients receiving ECT as an active comparator. Developing a better understanding of the feasibility and tolerability of adapting this treatment to an acutely ill patient population could lead to huge breakthroughs for clinician decision-making and for the further optimization of brain stimulation depression protocols. The results of this study can help guide future confirmatory efficacy trials of high-dose aiTBS by providing a better understanding of how feasibility, safety and tolerability compare to ECT, as well as unforeseen challenges of its use.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04441008
Study type Interventional
Source University of Iowa
Contact Benjamin Pace, MS
Phone (319) 384-9302
Email benjamin-pace@uiowa.edu
Status Not yet recruiting
Phase N/A
Start date December 2025
Completion date July 2029
View Details
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